Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

ATF3 drives senescence by reconstructing accessible chromatin profiles

(2021) Chao Zhang et al.   AGING CELL

Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology

(2021) Md. Farhad Hossain et al.   AGEING RESEARCH REVIEWS

PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila

(2020) Rosalie Elvira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuron‐Glia interaction: Molecular basis of Alzheimer’s Disease and Applications of Neuroproteomics

(2020) Abdallah Mohammad Ibrahim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease

(2020) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress

(2020) Annika Höhn et al.   Oxidative Medicine and Cellular Longevity

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

(2020) Harald Hampel et al.   Frontiers in Immunology

Evidence Linking Protein Misfolding to Quality Control in Progressive Neurodegenerative Diseases

(2020) Md. Tanvir Kabir et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease

(2020) Heather Buchanan et al.   MOLECULAR NEUROBIOLOGY

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

(2020) Stefan Reich et al.   Nature Communications

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

(2020) Sruti Rayaprolu et al.   NEUROPSYCHOPHARMACOLOGY

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts

(2020) Yiting Guan et al.   NUCLEIC ACIDS RESEARCH

Cellular proteostasis decline in human senescence

(2020) Niv Sabath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein damage, ageing and age-related diseases

(2019) Anita Krisko et al.   Open Biology

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation

(2019) Tamami Fujiki et al.   Scientific Reports

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

(2019) Vera I. Wiersma et al.   ACTA NEUROPATHOLOGICA

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

(2019) Omar Mohammed Amen et al.   Frontiers in Pharmacology

The Mitochondria–Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases

(2019) Ornella Moltedo et al.   Frontiers in Cell and Developmental Biology

Endoplasmic reticulum stress: A master regulator of metabolic syndrome

(2019) Sreelekshmi Mohan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigmversusknockin paradigm

(2018) Shoko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E 2 intracrine pathway

(2018) Johanna Cormenier et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The degradation pathway of a model misfolded protein is determined by aggregation propensity

(2018) Zhihao Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia

(2018) Dafina M. Angelova et al.   ACS Chemical Neuroscience

Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33

(2018) Yan Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10

(2018) Ali Abd-Ellah et al.   Scientific Reports

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease

(2018) Katherine R. Sadleir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

(2018) Paulina García-González et al.   Frontiers in Immunology

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

(2017) Yi-wei Wang et al.   Journal of Neuroinflammation

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1

(2017) Kyoung Wan Yoon et al.   Scientific Reports

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis

(2016) Leslie M. Baehr et al.   Aging-US

The role of endoplasmic reticulum stress in neurodegenerative disease

(2016) Chunchen Xiang et al.   APOPTOSIS

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Altered Proteins in the Aging Brain

(2016) Adila Elobeid et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

GPR40 receptor activation leads to CREB phosphorylation and improves cognitive performance in an Alzheimer’s disease mouse model

(2016) Muhammad Zahid Khan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases

(2016) S. A. Youssef et al.   VETERINARY PATHOLOGY

Regulation of ER stress-induced autophagy by GSK3β-TIP60-ULK1 pathway

(2016) Tiejian Nie et al.   Cell Death & Disease

GSK-3β controls NF-kappaB activity via IKKγ/NEMO

(2016) Senad Medunjanin et al.   Scientific Reports

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

(2015) Olivier Pluquet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

(2015) Sarah Gourmaud et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium

(2015) Sandra A. Jones et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

CREB expression mediates amyloid β-induced basal BDNF downregulation

(2015) Elyse Rosa et al.   NEUROBIOLOGY OF AGING

Unfolded protein response is activated in aged retinas

(2015) Austin R. Lenox et al.   NEUROSCIENCE LETTERS

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation

(2015) Eun Sun Jung et al.   Scientific Reports

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade

(2015) Richa Tyagi et al.   Cell Reports

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

The many functions of the endoplasmic reticulum chaperones and folding enzymes

(2014) Laura Halperin et al.   IUBMB LIFE

Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation

(2014) K. Hayakawa et al.   JOURNAL OF IMMUNOLOGY

Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging

(2014) Amiya Kumar Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

ER Stress Response in Human Cellular Models of Senescence

(2014) Liliana Matos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Neurodegenerative disease: Brain windfall

(2014) Katharine Gammon   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Emerging functions of the unfolded protein response in immunity

(2014) Sophie Janssens et al.   NATURE IMMUNOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms

(2014) Aric Flint Logsdon et al.   Frontiers in Cellular Neuroscience

Physiological roles of regulated Ire1 dependent decay

(2014) Dina S. Coelho et al.   Frontiers in Genetics

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation

(2013) Neelam Shahani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

(2013) Mark Halliday et al.   NEUROPHARMACOLOGY

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

The endoplasmic reticulum stress response in aging and age-related diseases

(2012) Marishka K. Brown et al.   Frontiers in Physiology

Endoplasmic reticulum stress in wake-active neurons progresses with aging

(2011) Nirinjini Naidoo et al.   AGING CELL

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions

(2011) Rui O. Costa et al.   NEUROBIOLOGY OF AGING

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Emerging Roles for XBP1, a sUPeR Transcription Factor

(2010) YIN HE et al.   GENE EXPRESSION

Plasma membrane microdomains in aging and disease

(2010) Yoshiko Ohno-Iwashita et al.   Geriatrics & Gerontology International

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers—Possibly caused by endoplasmic reticulum stress

(2010) Anna Nogalska et al.   NEUROSCIENCE LETTERS

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

(2009) Qiongqiong Zhou et al.   FEBS LETTERS

Down-regulation of Seladin-1 Increases BACE1 Levels and Activity through Enhanced GGA3 Depletion during Apoptosis

(2009) Timo Sarajärvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

(2009) Xianrong R. Mao et al.   Journal of Neuroinflammation

Old target new approach: an alternate NF-κB activation pathway via translation inhibition

(2009) Csaba F. László et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Calnuc plays a role in dynamic distribution of Gαi but not Gβ subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells

(2009) Ping Lin et al.   Molecular Neurodegeneration

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

(2009) J. Vogel et al.   NEUROPHARMACOLOGY

CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1

(2009) K. W. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

(2009) Arthur Kaser et al.   SEMINARS IN IMMUNOLOGY

Autoregulatory feedback loops terminating the NF-κB response

(2009) Florian Renner et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

NF-κB dictates the degradation pathway of IκBα

(2008) Erika Mathes et al.   EMBO JOURNAL

Seladin-1 Is a Fundamental Mediator of the Neuroprotective Effects of Estrogen in Human Neuroblast Long-Term Cell Cultures

(2008) Paola Luciani et al.   ENDOCRINOLOGY

Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β inductionvia X-box binding protein 1

(2008) Judith A. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD22: an inhibitory enigma

(2008) Jennifer A. Walker et al.   IMMUNOLOGY

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of the Alzheimer's disease-related gene seladin-1

(2008) Alessandro Peri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

Synergistic induction of ER stress by homocysteine and β-amyloid in SH-SY5Y cells☆

(2008) H KIM et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1

(2008) C. Citterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES