Article
Multidisciplinary Sciences
Nathan L. Price, Xinbo Zhang, Pablo Fernandez-Tussy, Abhishek K. Singh, Sean A. Burnap, Noemi Rotllan, Leigh Goedeke, Jonathan Sun, Alberto Canfran-Duque, Binod Aryal, Manuel Mayr, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: miR-33 is an intronic microRNA that regulates lipid metabolism by targeting ABCA1 to promote cholesterol efflux and improve HDL biogenesis. Liver-specific deficiency of miR-33 enhances glucose homeostasis, reduces fibrosis and inflammation, and increases circulating HDL-C levels. However, these changes are not sufficient to reduce atherosclerotic plaque size under hyperlipidemic conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Yuanli Wang, Rulong Chen, Jingyi Li, Guodong Zeng, Juntao Yuan, Jingran Su, Chunyan Wu, Zhongbing Lu, Fang Zhang, Wenjun Ding
Summary: This study found that VOdipic-Cl effectively prevented hepatic steatosis by controlling body weight, mitigating oxidative stress, and regulating the expression of genes related to lipid metabolism, ER stress, and immune response.
Article
Biochemistry & Molecular Biology
Dian-Guang Zhang, Tao Zhao, Xiao-Jian Xu, Wu-Hong Lv, Zhi Luo
Summary: The study investigated the effects of dietary selenium on lipid metabolism and selenoprotein expression in yellow catfish. Different selenium levels diets influenced lipid metabolism and selenoprotein expression, with low and excessive selenium levels leading to increased TGs deposition, possibly mediated by ER-resident selenoprotein expression and ER stress.
Article
Oncology
Yilong Zhu, Yiquan Li, Bing Bai, Chao Shang, Jinbo Fang, Jianan Cong, Wenjie Li, Shanzhi Li, Gaojie Song, Zirui Liu, Jin Zhao, Xiao Li, Guangze Zhu, Ningyi Jin
Summary: The study investigated the effects of Apoptin-induced endoplasmic reticulum stress on HepG-2 cells' lipid metabolism, migration, and invasion, and found that it can cause lasting ER stress response, alter lipid metabolism related enzymes expression levels, and reduce migration and invasion abilities of HepG-2 cells. Apoptin can also affect lipid metabolism through ER stress, potentially reducing tumor cells' migration and invasion abilities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Nathan L. Price, Leigh Goedeke, Yajaira Suarez, Carlos Fernandez-Hernando
Summary: miRNAs are critical regulators of biological processes and therapeutic targets, but misconceptions exist in the scientific community about their functions. This review focuses on miR-33 to highlight advances, hurdles, and new techniques in understanding the specific roles of miRNAs like miR-33.
EMBO MOLECULAR MEDICINE
(2021)
Article
Fisheries
Yuedong Shen, Xuejiao Li, Yangguang Bao, Tingting Zhu, Zhaoxun Wu, Bingqian Yang, Lefei Jiao, Qicun Zhou, Min Jin
Summary: This study aimed to determine the optimal dietary lipid requirement and evaluate the regulatory effects of different lipid levels on growth performance, lipid metabolism, and physiological responses in juvenile black seabream. The results showed that diets with 11.17% and 14.35% lipid levels improved growth performance and lipid metabolism. Excessive dietary lipid intake could lead to hepatic fat pathological changes, oxidative stress, and endoplasmic reticulum stress. These findings provide important insights into the regulation of growth, lipid metabolism, and physiological stress responses in black seabream.
Article
Multidisciplinary Sciences
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin
Summary: Inflammaging, associated with an increased risk of chronic disease, may be influenced by high levels of lipid droplets in monocytes and impaired fatty acid oxidation. Downregulation of PPAR-alpha and LD levels in monocytes may serve as novel biomarkers for inflammaging. Activation of PPAR-alpha in the elderly could potentially alleviate long-term inflammaging and prevent the development of life-limiting chronic diseases.
Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Zhengyan Gu, Rui Jia, Qin He, Liping Cao, Jinliang Du, Wenrong Feng, Galina Jeney, Pao Xu, Guojun Yin
Summary: The research demonstrated that BPA exposure disrupted lipid metabolism, induced oxidative stress, ERS, apoptosis, autophagy, and inflammatory response in the liver of common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao Meng Zhang, Yan Hong Gu, Hao Deng, Zheng Quan Xu, Ze Yuan Zhong, Xia Jie Lyu, Hui Min Jin, Xiu Hong Yang
Summary: The study demonstrates that double-filtration plasmapheresis (DFPP) can reduce lipid levels in patients with hyperlipidemia, downregulate proteins related to lipid metabolism, ER stress, and apoptosis in peripheral blood mononuclear cells (PBMCs), leading to decreased reactive oxygen species and release of inflammatory factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Microbiology
Xiuwen Yang, Jiayi Chen, Zixin Lu, Shan Huang, Shihao Zhang, Jintai Cai, Yezhen Zhou, Guanhua Cao, Jianhai Yu, Zhiran Qin, Wei Zhao, Bao Zhang, Li Zhu
Summary: This study revealed that lipid metabolism plays a core role in the replication of Enterovirus A71 (EV-A71), while endoplasmic reticulum (ER) stress has no direct restrictive effect on virus replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Elisa Martino, Anna Balestrieri, Luigi Mele, Celestino Sardu, Raffaele Marfella, Nunzia D'Onofrio, Giuseppe Campanile, Maria Luisa Balestrieri
Summary: This study analyzed the exosomal miRNA in buffalo milk and investigated its potential anticancer effects in colorectal cancer cells.
Article
Medicine, Research & Experimental
Yoshiaki Morishita, Aaron P. Kellogg, Dennis Larkin, Wei Chen, Suryakiran Vadrevu, Leslie Satin, Ming Liu, Peter Arvan
Summary: This study found that acute ER stress increases CIDE-A protein levels in thyroid cells, while chronic ER stress results in lower mRNA levels of CIDE-A. Furthermore, CIDE-A mRNA response to a new acute ER stress challenge is reduced in cells surviving chronic ER stress. CIDE-A may be a novel marker associated with a noncanonical ER stress response program.
Review
Medicine, Research & Experimental
Jun Yi, Qingluo Zhou, Jishang Huang, Shuo Niu, Guanglin Ji, Tiansheng Zheng
Summary: Lipid metabolism disorder may promote the pathogenesis of intervertebral disc degeneration (IDD) by activating inflammatory responses, endoplasmic reticulum stress, and oxidative stress, and inhibiting autophagy, leading to extracellular matrix degradation, cell apoptosis, and cartilage calcification in the intervertebral discs. Inhibition of lipid metabolism disorder may be an effective strategy for the therapeutic management of IDD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Article
Cell Biology
Xiaojie Wang, Liang Wang, Mingyi Luo, Qian Bu, Chunqi Liu, Linhong Jiang, Rui Xu, Shaomin Wang, Haoluo Zhang, Jiamei Zhang, Xuemei Wan, Hongchun Li, Yonghai Wang, Bin Liu, Ying Zhao, Yuanyuan Chen, Yanping Dai, Min Li, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Summary: Clarithromycin (CLA) treatment causes anxiety-like behaviors, possibly through altered glycerophospholipid metabolism.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Chemistry, Applied
Zhang-Yang Shen, Ying-Ying Zhao, Ze-Hua Qiao, Zhen Xie, Ruo-Qing Guan, Ze-Yu Liu, Yan-Ping Liu, Guang-Ying Chen, Yan-Hui Fu
Summary: A phytochemical investigation of the fruits of Morinda citrifolia resulted in the discovery of a new anthraquinone, moricitrifone, along with seven known anthraquinones. The antiproliferative activities of these compounds were evaluated against multiple human cancer cell lines, and they exhibited significant inhibition of cell proliferation.
NATURAL PRODUCT RESEARCH
(2023)
Article
Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Environmental Sciences
Hongchuan Li, Rui Jin, Zhaowen Xu, Hongxiang Hu, Yusef Kianpoor Kalkhajeh, Yingying Zhao, Linchuan Zhan
Summary: In this study, the potential of chelate tetrasodium glutamate diacetate (GLDA) combined with Tagetes patula L. to remediate cadmium-contaminated soil was investigated. The results showed that GLDA application significantly increased the biomass and cadmium content of Tagetes patula, indicating the efficacy of GLDA for the remediation of cadmium-contaminated farmlands.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Tongchuan Chen, Yingying Zhao, Qianqian Wang, Wenting Wang, Aimin An
Summary: This paper proposes a Distributed Secondary Compensation Control (DSCC) method to solve the problems of the transmission system controlled by traditional droop control. It improves the dynamic response of the system and its fault ride through capability.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Environmental Sciences
Zhennan Lin, Shufeng Chen, Fangchao Liu, Jianxin Li, Jie Cao, Keyong Huang, Fengchao Liang, Jichun Chen, Hongfan Li, Jianfeng Huang, Dongsheng Hu, Chong Shen, Yingxin Zhao, Xiaoqing Liu, Ling Yu, Xiangfeng Lu, Dongfeng Gu
Summary: Long-term exposure to high levels of PM2.5 is associated with increased blood pressure and hypertension risk. In China, for each 10μg/m3 increase in PM2.5 concentration, systolic and diastolic blood pressure increased by 1.67mmHg and 0.45mmHg, respectively, and the prevalence of hypertension increased by 29%. The relationship between PM2.5 and blood pressure may be non-linear.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Qingmei Cui, Zhongying Liu, Jianxin Li, Fangchao Liu, Xiaoge Niu, Chong Shen, Dongsheng Hu, Keyong Huang, Shufeng Chen, Yingxin Zhao, Fanghong Lu, Xiaoqing Liu, Jie Cao, Laiyuan Wang, Hongxia Ma, Ling Yu, Xianping Wu, Ying Li, Huan Zhang, Xingbo Mo, Liancheng Zhao, Zhibin Hu, Hongbing Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: This study aims to examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations. The results showed that individuals with a favourable CVH profile demonstrated similar relative effects across Polygenic Risk Score (PRS) categories, reducing the CAD relative risk by a similar magnitude. Individuals with high PRS achieved the greatest benefit from favourable CVH, mitigating the risk to the average level of the population. Attaining favourable CVH should be encouraged for all individuals, especially those with high genetic susceptibility.
Article
Agriculture, Multidisciplinary
Xiao-Han Sun, Mei-Wei Lv, Ying-Xin Zhao, Hao Zhang, Muhammad Asmat Ullah Saleem, Yi Zhao, Jin-Long Li
Summary: This study determined the mechanism of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJAMPK-PGC1 alpha pathway. The results showed that Cd activated the NLRP3 inflammasome and caused hepatocyte pyroptosis. Furthermore, Cd also increased hepatic fibrosis. However, the co-treatment of nano-Se and Cd significantly reduced the degree of fibrosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Zirui Ye, Miao Qi, Yingming Zhao, Wei Wei, X. George Xu
Summary: This study estimated the fetal and pediatric doses from chest CT scans performed during the COVID-19 pandemic. Organ and effective doses were calculated using VirtualDose-CT software. The results showed that fetal absorbed doses ranged from 0.04 to 0.61 mGy depending on the gestational age, and extending the scan range to the abdominal region increased fetal doses by almost 4-fold. The findings provide valuable information for radiologists and patients to minimize unnecessary radiation exposure.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Agronomy
Yingying Zhao, Deng Yan, Jinjing Liu, Shuzhen Yang, Dongmei Li, Litao Peng
Summary: In this study, the function of the vacuolar ATPase subunit H (VmaH) in Penicillium digitatum was characterized. The results showed that silencing the VmaH gene reduced cell growth and pathogenicity of P. digitatum, increased vacuolar pH and decreased extracellular pH. Furthermore, VmaH gene silencing inhibited the expression of transport genes and interfered with nutrient metabolic processing, leading to altered cell morphology and weakened pathogenicity.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Editorial Material
Cell Biology
Gaoxiang Zhao, Qian Lin, Zhaoyuan Meng, Xinlei Sheng, Leina Ma, Yingming Zhao
Article
Green & Sustainable Science & Technology
Zheng Ma, Zhen Xing, Yingying Zhao, Yiru Hu
Summary: This paper investigates the influence of freeze-thaw cycles on the dynamic strength properties of silty clay fillers before and after cement improvement, and quantifies the improvement effects of cement improvement. The results show that cement modification significantly improves the dynamic strength parameters of silty clay even after multiple freeze-thaw cycles, providing a useful reference for subgrade improvement along the silty clay railway in northern China.
Article
Materials Science, Multidisciplinary
Ying Zhao, Lian-Cai An, Kai Li, Yong-Ji Gong, Tian-Meng Guo, Fei-Fei Gao, Yang Lei, Quanwen Li, Wei Li, Xian-He Bu
Summary: Hybrid organic-inorganic piezoelectrics have gained attention for their fascinating performance, ease of synthesis, and mechanical flexibility. However, most reported systems contain toxic heavy metals or are unstable due to metal halide bonds. In this research, a stable zero-dimensional hybrid piezoelectric material based on an environmentally friendly anion of SCN- was synthesized. The resulting flexible composite films showed exceptional mechanical energy harvesting properties, outperforming state-of-the-art piezoelectric devices, with excellent durability and stability.
SCIENCE CHINA-MATERIALS
(2023)
Article
Computer Science, Artificial Intelligence
Ying Zhao, Dong Yuan, Jia Tina Du, Jinjun Chen
Summary: Directional distribution analysis is essential for abstracting dispersion and orientation of spatial datasets, but it must be used cautiously to protect individuals' privacy. There is a tension between accurate directional distribution results and location privacy. In this paper, we propose a geo-ellipse-indistinguishability privacy notion to protect individual location data and present elliptical privacy mechanisms based on gamma distribution and multivariate normal distribution. The empirical evaluation shows that our proposed elliptical approach achieves significantly higher directional distribution utility compared to circular noise function based methods.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Juan-Juan Li, Rui-Xue Rong, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu, Ke-Rang Wang, Dong-Sheng Guo
Summary: Host-guest drug delivery systems (HGDDSs) have been studied to modify therapeutic agents and improve treatment effects. The targeting ability of HGDDSs needs continuous improvement for the development of precision medicine. In this study, a lactose-modified azocalix[4]arene (LacAC4A) was used as a triple targeting drug carrier for antitumor purposes. LacAC4A showed effective tumor growth suppression through passive targeting, active targeting, and stimuli-responsive targeting. This design principle provides a new material for drug delivery systems.
MATERIALS HORIZONS
(2023)