Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

(2015) Saleh Rachidi et al.   JOURNAL OF HEPATOLOGY

ER stress induces epithelial differentiation in the mouse oesophagus

(2014) Sanne L Rosekrans et al.   GUT

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(2014) Amy S. Lee et al.   HEPATOLOGY

Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity

(2014) S. A. Heiney et al.   JOURNAL OF NEUROSCIENCE

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

Differential requirement of GRP94 and GRP78 in mammary gland development

(2014) Genyuan Zhu et al.   Scientific Reports

CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo

(2014) Benjamin T. Spike et al.   Stem Cell Reports

Targeted Deletion of ER Chaperone GRP94 in the Liver Results in Injury, Repopulation of GRP94-Positive Hepatocytes, and Spontaneous Hepatocellular Carcinoma Development in Aged Mice

(2014) Wan-Ting Chen et al.   NEOPLASIA

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases

(2014) Beichu Guo et al.   Frontiers in Genetics

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis

(2013) Wan-Ting Chen et al.   HEPATOLOGY

GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN

(2013) W-T Chen et al.   ONCOGENE

Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production

(2013) Yi Zhang et al.   PLoS One

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway

(2013) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of GRP94 in the Hematopoietic System Alters Proliferation Regulators in Hematopoietic Stem Cells

(2013) Biquan Luo et al.   STEM CELLS AND DEVELOPMENT

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Integrin  IIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta

(2013) J.-C. Boisset et al.   Biology Open

Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors

(2013) Hui Han et al.   Frontiers in Genetics

Conflicting Roles of Molecules in Hepatocarcinogenesis: Paradigm or Paradox

(2012) Gen-Sheng Feng   CANCER CELL

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

(2012) Elisabeth R. Barton et al.   FASEB JOURNAL

GRP78 plays an essential role in adipogenesis and postnatal growth in mice

(2012) Genyuan Zhu et al.   FASEB JOURNAL

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers

(2012) Michael J. Gray et al.   INTERNATIONAL JOURNAL OF CANCER

Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain

(2012) Carlita B. Favero et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development

(2012) R. Hill et al.   MOLECULAR CANCER THERAPEUTICS

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

(2012) Shiuan Wey et al.   PLoS One

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

(2011) S. Wey et al.   BLOOD

A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis

(2011) D. Dong et al.   CANCER RESEARCH

Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78

(2011) Kenichi Miharada et al.   Cell Stem Cell

Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice

(2011) David A. Hess et al.   GASTROENTEROLOGY

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

(2011) Cheng Ji et al.   HEPATOLOGY

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis

(2011) C E Lowe et al.   INTERNATIONAL JOURNAL OF OBESITY

Liver stem/progenitor cells: their characteristics and regulatory mechanisms

(2011) M. Tanaka et al.   JOURNAL OF BIOCHEMISTRY

Novel Mechanism of Anti-apoptotic Function of 78-kDa Glucose-regulated Protein (GRP78)

(2011) Hui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The haematopoietic stem cell niche at a glance

(2011) C. Lo Celso et al.   JOURNAL OF CELL SCIENCE

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

The Endoplasmic Reticulum Chaperone Protein GRP94 Is Required for Maintaining Hematopoietic Stem Cell Interactions with the Adult Bone Marrow Niche

(2011) Biquan Luo et al.   PLoS One

Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis

(2010) Risheng Ye et al.   AMERICAN JOURNAL OF PATHOLOGY

Re-Examination of CD91 Function in GRP94 (Glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-Presentation

(2010) A. R. Jockheck-Clark et al.   JOURNAL OF IMMUNOLOGY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Targeted Mutation of the Mouse Grp94 Gene Disrupts Development and Perturbs Endoplasmic Reticulum Stress Signaling

(2010) Changhui Mao et al.   PLoS One

GRP94 in ER quality control and stress responses

(2010) Davide Eletto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors

(2009) Olga Ostrovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

(2009) M. Staron et al.   BLOOD

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

(2009) M Wang et al.   CELL DEATH AND DIFFERENTIATION

The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for Adipogenesis

(2009) Haibo Sha et al.   Cell Metabolism

Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin

(2009) Eri Mizuhara et al.   DEVELOPMENTAL BIOLOGY

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism

(2009) Éva Kereszturi et al.   HUMAN MUTATION

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

(2009) Chih-Chi Andrew Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

(2009) Derrick J. Todd et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis

(2009) Jiang Liu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Heat Shock Protein 96 Is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily via TLR2 Signaling

(2009) Q.-Q. Huang et al.   JOURNAL OF IMMUNOLOGY

Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

(2009) J A Kelber et al.   ONCOGENE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin

(2008) B. Liu et al.   BLOOD

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

(2008) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE