Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

(2020) Jonathan R. Davey et al.   FASEB JOURNAL

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

(2020) Ruhang Tang et al.   Science Advances

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

(2020) Yasuo Oguri et al.   CELL

Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons

(2020) Sai P. Pydi et al.   Science Advances

Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

(2019) Lidia I. Arhire et al.   Frontiers in Endocrinology

Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

(2019) Haoyu Li et al.   PLoS One

An update on the role of irisin in the regulation of endocrine and metabolic functions

(2018) Mohamed Omer Mahgoub et al.   PEPTIDES

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

(2018) Rajan Singh et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions

(2017) Abdikarim Abdullahi et al.   ENDOCRINE REVIEWS

Getting the Skinny on Follistatin and Fat

(2017) Jia-Xu Li et al.   ENDOCRINOLOGY

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues

(2017) Rajan Singh et al.   ENDOCRINOLOGY

Reconstitution ofUCP1using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

(2017) Qiantao Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs

(2017) Chunbo Cai et al.   Oncotarget

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

(2017) D. Pérez-Sotelo et al.   Scientific Reports

Crosstalk between adipokines and myokines in fat browning

(2016) A. Rodríguez et al.   Acta Physiologica

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice

(2016) Lavanya Vishvanath et al.   Cell Metabolism

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

(2016) Geerte Hoeke et al.   CIRCULATION RESEARCH

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

(2016) Allyson K. Palmer et al.   EXPERIMENTAL GERONTOLOGY

Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378

(2016) Jiyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes

(2016) Shanshan Gao et al.   PLoS One

White Adipose Tissue Browning: A Double-edged Sword

(2016) Abdikarim Abdullahi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue

(2016) Yan Tang et al.   Journal of Molecular Cell Biology

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

(2016) Daniel C. Berry et al.   Nature Communications

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

(2016) Luís Martins et al.   Cell Reports

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

(2016) Hong Tang et al.   EBioMedicine

Global metabolomic profiling targeting childhood obesity in the Hispanic population

(2015) Nancy F Butte et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity

(2015) Xiao-Qing Xiong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140

(2015) Fang Hu et al.   DIABETES

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review

(2015) Ning Chen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

Codon optimization and expression of irisin in Pichia pastoris GS115

(2015) Huikun Duan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

(2015) J Dong et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice

(2015) Chunxia Zhao et al.   MOLECULAR THERAPY

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

(2015) Jerry R Mendell et al.   MOLECULAR THERAPY

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

(2015) Chao Xie et al.   PLoS One

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

(2015) Leyre Martínez-Fernández et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

The Therapeutic Potential of Brown Adipocytes in Humans

(2015) Craig Porter et al.   Frontiers in Endocrinology

Insights into an adipocyte whitening program

(2015) Bradford G Hill   Adipocyte

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Irisin: ‘fat’ or artefact

(2014) A.B. Crujeiras et al.   CLINICAL ENDOCRINOLOGY

MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes

(2014) H.-J. Kim et al.   DIABETES

Characterization of the metabolic effects of irisin on skeletal musclein vitro

(2014) R. A. Vaughan et al.   DIABETES OBESITY & METABOLISM

Follistatin promotes adipocyte differentiation, browning, and energy metabolism

(2014) Melissa Braga et al.   JOURNAL OF LIPID RESEARCH

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

(2014) T. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

(2014) Wenshan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes

(2014) S. Ussar et al.   Science Translational Medicine

Regulation of UCP1 in the Browning of Epididymal Adipose Tissue byβ3-Adrenergic Agonist: A Role for MicroRNAs

(2014) Zongji Zheng et al.   International Journal of Endocrinology

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects

(2014) P Lopez-Legarrea et al.   Nutrition & Diabetes

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

(2013) Rocio de la Iglesia et al.   CLINICAL ENDOCRINOLOGY

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

(2013) Tizhong Shan et al.   FASEB JOURNAL

Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

(2013) Kyung Hee Park et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin in obesity and type 2 diabetes

(2013) Kurt Højlund et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

(2013) Hui-Jie Zhang et al.   JOURNAL OF HEPATOLOGY

Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise

(2013) Silja Raschke et al.   MEDIATORS OF INFLAMMATION

Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients

(2013) Ana B. Crujeiras et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MiR-27 orchestrates the transcriptional regulation of brown adipogenesis

(2013) Lei Sun et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

(2013) Melissa Braga et al.   Obesity

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis

(2013) Wen Guo et al.   PLoS One

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2

(2013) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

(2013) Shu-Wen Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-133a Regulates Adipocyte Browning In Vivo

(2013) Weiyi Liu et al.   PLoS Genetics

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Brown Adipose Tissue

(2012) Charmaine S. Tam et al.   CIRCULATION

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

(2012) Alan Koncarevic et al.   ENDOCRINOLOGY

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Relevance of brown adipose tissue in infancy and adolescence

(2012) Vicente Gilsanz et al.   PEDIATRIC RESEARCH

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

(2012) Melissa N. Barber et al.   PLoS One

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Transforming Growth Factor-β, Bioenergetics, and Mitochondria in Renal Disease

(2012) Gabriella Casalena et al.   SEMINARS IN NEPHROLOGY

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

(2012) Masaki Mori et al.   PLOS BIOLOGY

Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice

(2011) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

(2011) Lei Cao et al.   Cell Metabolism

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

Building muscle, browning fat and preventing obesity by inhibiting myostatin

(2011) N. K. LeBrasseur   DIABETOLOGIA

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization

(2011) Won Kon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: Potential role of follistatin in mediating testosterone action

(2011) Melissa Braga et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Follistatin and Follistatin Like-3 Differentially Regulate Adiposity and Glucose Homeostasis

(2011) Melissa L. Brown et al.   Obesity

Enhanced Metabolic Flexibility Associated with Elevated Adiponectin Levels

(2010) Ingrid Wernstedt Asterholm et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

(2010) Andrea Frontini et al.   Cell Metabolism

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

(2010) Barbara L. Bernardo et al.   PLoS One

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

(2009) Hélène Gilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

(2009) J. R.B. Perry et al.   DIABETES

Transforming Growth Factor- 1 and Incident Type 2 Diabetes: Results from the MONICA/KORA case-cohort study, 1984-2002

(2009) C. Herder et al.   DIABETES CARE

Major Urinary Protein-1 Increases Energy Expenditure and Improves Glucose Intolerance through Enhancing Mitochondrial Function in Skeletal Muscle of Diabetic Mice

(2009) Xiaoyan Hui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice

(2009) Yingjiang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

(2009) J. Kota et al.   Science Translational Medicine

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways

(2008) Rajan Singh et al.   ENDOCRINOLOGY

AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation

(2008) Rangnath Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

(2008) A. M. Haidet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice

(2007) Masashi Nakatani et al.   FASEB JOURNAL