Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Mechanisms involved in follistatin‐induced hypertrophy and increased insulin action in skeletal muscle

(2019) Xiuqing Han et al.   Journal of Cachexia Sarcopenia and Muscle

Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain

(2018) Melissa M. Page et al.   FASEB JOURNAL

Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice

(2018) Sarah A. Tersey et al.   FASEB JOURNAL

Inactivating hepatic follistatin alleviates hyperglycemia

(2018) Rongya Tao et al.   NATURE MEDICINE

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases

(2018) Rajan Singh et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

(2016) Catherine E. Winbanks et al.   Science Translational Medicine

ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation

(2015) Doriane Ripoche et al.   MOLECULAR AND CELLULAR BIOLOGY

Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice

(2015) Chunxia Zhao et al.   MOLECULAR THERAPY

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

(2015) Jerry R Mendell et al.   MOLECULAR THERAPY

Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice

(2014) Ja Young Kim-Muller et al.   Cell Metabolism

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Beta-Cell Dedifferentiation and Type 2 Diabetes

(2013) Yuval Dor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

(2012) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis

(2011) Masashi Nakatani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity

(2011) A. C. McPherron et al.   DIABETES OBESITY & METABOLISM

Reciprocal modulation of adult beta cell maturity by activin A and follistatin

(2010) M. Szabat et al.   DIABETOLOGIA

A new ‘total’ activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples

(2009) Helen Ludlow et al.   CLINICAL ENDOCRINOLOGY

Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function

(2009) Huei-Min Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

(2009) J. Kota et al.   Science Translational Medicine

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

Activin B receptor ALK7 is a negative regulator of pancreatic  -cell function

(2008) P. Bertolino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA