FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

Irisin, Turning Up the Heat

(2012) Francesc Villarroya   Cell Metabolism

From white to brown fat through the PGC-1 -dependent myokine irisin: implications for diabetes and obesity

(2012) J. I. Castillo-Quan   Disease Models & Mechanisms

Muscle tissue as an endocrine organ: Comparative secretome profiling of slow-oxidative and fast-glycolytic rat muscle explants and its variation with exercise

(2012) Arturo Roca-Rivada et al.   Journal of Proteomics

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Is irisin a human exercise gene?

(2012) James A. Timmons et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Irisin—behind the benefits of exercise

(2012) Andreia Cunha   Nature Reviews Endocrinology

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Irisin, Light My Fire

(2012) D. P. Kelly   SCIENCE

Irisin: A new potential hormonal target for the treatment of obesity and type 2 diabetes

(2012) Fabian Sanchis-Gomar et al.   Journal of Diabetes

Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

(2011) Arturo Roca-Rivada et al.   Journal of Proteomics

Age, sex, and lactating status regulate ghrelin secretion and GOAT mRNA levels from isolated rat stomach

(2010) O. Al-Massadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Brown fat thermogenesis and body weight regulation in mice: relevance to humans

(2010) L P Kozak et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

(2010) Takeshi Yoneshiro et al.   Obesity

Peripheral leptin and ghrelin receptors are regulated in a tissue-specific manner in activity-based anorexia

(2010) María Pardo et al.   PEPTIDES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training

(2009) Karen Ruschke et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The role of fat topology in the risk of disease

(2009) Y Matsuzawa   INTERNATIONAL JOURNAL OF OBESITY

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

(2009) Georgina S. Butler et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Subcutaneous and visceral adipose tissue: structural and functional differences

(2009) M. Mohsen Ibrahim   Obesity Reviews

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why are we shaped differently, and why does it matter?

(2008) Sylvia Santosa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Review on leptin and adiponectin responses and adaptations to acute and chronic exercise

(2008) A. Bouassida et al.   BRITISH JOURNAL OF SPORTS MEDICINE

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS