Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Sarcopenia and Obesity

(2011) Debra L. Waters et al.   CLINICS IN GERIATRIC MEDICINE

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

(2011) C. K. Tan et al.   DIABETES

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway

(2011) C. Zhang et al.   DIABETOLOGIA

Emerging Roles for the Transforming Growth Factor-β Superfamily in Regulating Adiposity and Energy Expenditure

(2011) Nader Zamani et al.   ENDOCRINE REVIEWS

Separation of the gluconeogenic and mitochondrial functions of PGC-1  through S6 kinase

(2011) Y. Lustig et al.   GENES & DEVELOPMENT

Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization

(2011) Won Kon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

(2010) Barbara L. Bernardo et al.   PLoS One

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

(2010) Marcus D. Goncalves et al.   PLoS One

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions

(2009) Francesca Forner et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

(2009) Tim J. Schulz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

UCP1: its involvement and utility in obesity

(2009) L P Kozak et al.   INTERNATIONAL JOURNAL OF OBESITY

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake

(2008) Jennifer A. Calvo et al.   JOURNAL OF APPLIED PHYSIOLOGY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Sarcopenic obesity: A new category of obesity in the elderly

(2008) Mauro Zamboni et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES