Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

(2020) Edward C. Deehan et al.   Cell Host & Microbe

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function

(2020) Francois Brial et al.   Cell Reports

Dietary patterns are associated with likelihood of hepatic steatosis among US adults

(2020) Mohsen Mazidi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Contribution of macronutrients to obesity: implications for precision nutrition

(2020) Rodrigo San-Cristobal et al.   Nature Reviews Endocrinology

Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism

(2020) Shu-Lin Chang et al.   Nutrients

Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990–2017: a population-based observational study

(2020) Xiaojun Ge et al.   BMJ Open

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

(2020) Kelly S. Swanson et al.   Nature Reviews Gastroenterology & Hepatology

Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient

(2020) Samuel Jannel et al.   Journal of Marine Science and Engineering

Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats

(2019) Heather A. Paul et al.   FASEB JOURNAL

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid

(2019) Marine Coué et al.   Nutrients

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

(2019) Cyrielle Caussy et al.   Nature Communications

Spirulina supplementation in a mouse model of diet-induced liver fibrosis reduced the pro-inflammatory response of splenocytes

(2019) Tho X. Pham et al.   BRITISH JOURNAL OF NUTRITION

Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

(2019) Xuying Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SCFAs — the thin microbial metabolic line between good and bad

(2019) Matteo Serino   Nature Reviews Endocrinology

Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice

(2019) Minyi Qian et al.   Marine Drugs

Effects of high-protein diet on glycemic control, insulin resistance and blood pressure in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

(2019) Zhangping Yu et al.   CLINICAL NUTRITION

Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation

(2019) Fei Chen et al.   HEPATOLOGY

Marine Natural Products: A Source of Novel Anticancer Drugs

(2019) Shaden A. M. Khalifa et al.   Marine Drugs

Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer

(2019) Tahereh Hosseinabadi et al.   PHYTOTHERAPY RESEARCH

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Resistant starch from green banana (Musa sp.) attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice

(2019) Carolyne Pimentel Rosado et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

(2019) Paula Fernández-Palanca et al.   Nutrients

Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects

(2019) Si-Min Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes

(2018) Xihong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice

(2018) Shu Yun Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells

(2018) Qingqing Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice

(2018) Caixia Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol improves high-fat diet induced fatty liver and insulin resistance by concomitantly inhibiting proteolytic cleavage of sterol regulatory element-binding proteins, free fatty acid oxidation, and intestinal triglyceride absorption

(2018) Eman F. Khaleel et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

(2018) Adil Mardinoglu et al.   Cell Metabolism

Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease

(2018) Roger F. Butterworth et al.   DIGESTIVE DISEASES

Higher serum carotenoids associated with improvement of non-alcoholic fatty liver disease in adults: a prospective study

(2018) Mian-li Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7

(2018) Eman T. Mehanna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase

(2018) Taewon Yuk et al.   Evidence-based Complementary and Alternative Medicine

Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease

(2018) Bangling Zhang et al.   FASEB JOURNAL

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

Pectin Alleviates High Fat (Lard) Diet-Induced Nonalcoholic Fatty Liver Disease in Mice: Possible Role of Short-Chain Fatty Acids and Gut Microbiota Regulated by Pectin

(2018) Wenfeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

(2018) Farnush Bakhshimoghaddam et al.   JOURNAL OF NUTRITION

Replacement of soybean oil by fish oil increases cytosolic lipases activities in liver and adipose tissue from rats fed a high-carbohydrate diets

(2018) Angélica Heringer Rodrigues et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models

(2018) Prasant Kumar Jena et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice

(2018) Celina Carvalho BORGES et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

(2018) Somayyeh Asghari et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin

(2018) Peiyi Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice

(2018) Cheng-Chung Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review

(2018) Atefeh Tajmohammadi et al.   PHYTOTHERAPY RESEARCH

Chitobiose alleviates oleic acid-induced lipid accumulation by decreasing fatty acid uptake and triglyceride synthesis in HepG2 cells

(2018) Xiaodan Li et al.   Journal of Functional Foods

Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model

(2018) Longmei Wang et al.   Journal of Functional Foods

Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

(2018) Takanori Tsuda   Food & Function

Folate and B12 Levels Correlate with Histological Severity in NASH Patients

(2018) Mahmud Mahamid et al.   Nutrients

Practical Dietary Recommendations for the Prevention and Management of Nonalcoholic Fatty Liver Disease in Adults

(2018) Elena S George et al.   Advances in Nutrition

Butyrate: A Double-Edged Sword for Health?

(2018) Hu Liu et al.   Advances in Nutrition

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet

(2018) Simin Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice

(2018) Stanley Dumeus et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway

(2018) Qiang Ou et al.   DIGESTIVE DISEASES AND SCIENCES

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Perilla Oil Decreases Aortic and Hepatic Lipid Accumulation by Modulating Lipogenesis and Lipolysis in High-Fat Diet-Fed Mice

(2018) So Ra Kim et al.   JOURNAL OF MEDICINAL FOOD

Dietary salmon milt extracts attenuate hepatosteatosis and liver dysfunction in diet-induced fatty liver model

(2018) Toshihiro Sakurai et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Gut microbiome, microbial metabolites and the development of NAFLD

(2018) Cyrielle Caussy et al.   Nature Reviews Gastroenterology & Hepatology

Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol

(2018) Janin Henkel et al.   Nutrients

Rosmarinic acid attenuates hepatic steatosis by modulating ER stress and autophagy in oleic acid-induced HepG2 cells

(2018) Govindaraj Jayanthy Balachander et al.   RSC Advances

Therapeutic efficacy of polydatin for nonalcoholic fatty liver disease via regulating inflammatory response in obese mice

(2018) Juan-Fen Mo et al.   RSC Advances

Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

(2018) Jianzhong Ye et al.   Frontiers in Microbiology

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

(2018) Vishal Singh et al.   CELL

The role of the microbiome in NAFLD and NASH

(2018) Aleksandra A Kolodziejczyk et al.   EMBO Molecular Medicine

Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model

(2018) Guohong Qin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

(2018) Sonya Hosseinpour-Arjmand et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

The gut microbiota at the intersection of diet and human health

(2018) Christopher L. Gentile et al.   SCIENCE

Non-alcoholic fatty liver disease (NAFLD) models in drug discovery

(2017) Banumathi K. Cole et al.   Expert Opinion on Drug Discovery

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial

(2017) Henrik Munch Roager et al.   GUT

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway

(2017) Xiaojuan Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation

(2017) Chun-Xue Cui et al.   JOURNAL OF ETHNOPHARMACOLOGY

Treatment of NAFLD with diet, physical activity and exercise

(2017) Manuel Romero-Gómez et al.   JOURNAL OF HEPATOLOGY

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

(2017) Aafke W. F. Janssen et al.   JOURNAL OF LIPID RESEARCH

Protective Effects and Mechanism of Meretrix meretrix Oligopeptides against Nonalcoholic Fatty Liver Disease

(2017) Fangfang Huang et al.   Marine Drugs

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

(2017) Alka Choudhary et al.   Marine Drugs

The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease

(2017) Sheng Zhong et al.   MEDICINE

(-)-Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet

(2017) Hui Cheng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease

(2017) Cheng Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-α in adipose tissue

(2017) Dong-Hyeon Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alpha-Galacto-Oligosaccharides at Low Dose Improve Liver Steatosis in a High-Fat Diet Mouse Model

(2017) Eric Chappuis et al.   MOLECULES

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction

(2017) Chen Shen et al.   NUTRITION RESEARCH

RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene

(2017) Peng Han et al.   Oxidative Medicine and Cellular Longevity

Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice

(2017) Dhirendra Pratap Singh et al.   PHARMACOLOGICAL RESEARCH

Pilose antler peptide attenuates high-fat-diet-induced liver injury

(2017) Lixin Xu et al.   TOXICOLOGY MECHANISMS AND METHODS

Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

(2017) Yi Tan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism

(2017) Lin Ding et al.   Journal of Functional Foods

B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy

(2017) Janet Schloss et al.   Current Oncology Reports

A comprehensive review of the health perspectives of resveratrol

(2017) Abdur Rauf et al.   Food & Function

Effect of Mediterranean Diet and Antioxidant Formulation in Non-Alcoholic Fatty Liver Disease: A Randomized Study

(2017) Ludovico Abenavoli et al.   Nutrients

Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a NAFLD/NASH mouse model

(2017) Alessandra Tessitore et al.   Oncotarget

Pilose antler peptide attenuates high-fat-diet-induced liver injury

(2017) Lixin Xu et al.   TOXICOLOGY MECHANISMS AND METHODS

Ginseng seed oil ameliorates hepatic lipid accumulation in vitro and in vivo

(2017) Go Woon Kim et al.   Journal of Ginseng Research

Fructo-oligosaccharides and intestinal barrier function in a methionine–choline-deficient mouse model of nonalcoholic steatohepatitis

(2017) Kotaro Matsumoto et al.   PLoS One

Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity

(2016) Shiori Takashima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity

(2016) Xia Tian et al.   BRAIN RESEARCH

The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease

(2016) Maria Del Ben et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats

(2016) Masatoshi Kubota et al.   BRITISH JOURNAL OF NUTRITION

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease

(2016) Prasanthi Jegatheesan et al.   CLINICAL NUTRITION

Prebiotics and synbiotics

(2016) Janina A. Krumbeck et al.   CURRENT OPINION IN GASTROENTEROLOGY

Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage

(2016) Jeongeun Hyun et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease

(2016) Yunes Panahi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice

(2016) Xianbin Cai et al.   JOURNAL OF GASTROENTEROLOGY

Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease

(2016) Hitoshi Watanabe et al.   JOURNAL OF NUTRITION

A Whole-Grain Diet Reduces Cardiovascular Risk Factors in Overweight and Obese Adults: A Randomized Controlled Trial

(2016) John P Kirwan et al.   JOURNAL OF NUTRITION

Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt

(2016) Yaoyao Jia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease

(2016) Yanjun Liu et al.   LIPIDS

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

(2016) Yueli Tian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Prolonged feeding with green tea polyphenols exacerbates cholesterol-induced fatty liver disease in mice

(2016) Nina Hirsch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Fuzhuan tea consumption imparts hepatoprotective effects and alters intestinal microbiota in high saturated fat diet-fed rats

(2016) Michelle T. Foster et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice

(2016) Haizhao Song et al.   NUTRITION

Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching

(2016) Chu-Sook Kim et al.   Nutrition Research and Practice

A local mechanism by which alcohol consumption causes cancer

(2016) Miguel López-Lázaro   ORAL ONCOLOGY

Eicosapentaenoic acid-containing phosphatidylcholine alleviated lipid accumulation in orotic acid-induced non-alcoholic fatty liver

(2016) Yanjun Liu et al.   Journal of Functional Foods

Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis

(2016) Yinhua Ni et al.   Nutrients

Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes

(2016) Jinying Zheng et al.   Nutrients

Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet

(2016) Shu-Fang Xia et al.   Nutrients

Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway

(2016) H L Chen et al.   Nutrition & Diabetes

Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats

(2016) Wen-Dee Chiang et al.   Food & Nutrition Research

Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation inApoe−/−Mice Fed with High-Fat Diet

(2016) Zhan Liu et al.   Journal of Diabetes Research

Raphanus sativus cv. Sango Sprout Juice Decreases Diet-Induced Obesity in Sprague Dawley Rats and Ameliorates Related Disorders

(2016) Fabio Vivarelli et al.   PLoS One

Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism

(2015) Victoria Sid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The potential of flavonoids in the treatment of non-alcoholic fatty liver disease

(2015) Bregje Van De Wier et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Prevention and Reversal of Lipotoxicity-Induced Hepatic Insulin Resistance and Steatohepatitis in Mice by an Antioxidant Carotenoid, β-Cryptoxanthin

(2015) Yinhua Ni et al.   ENDOCRINOLOGY

Effects of epicatechin gallate (ECG) on fetal bovine serum (FBS)-induced steatosis in human liver cell line L02 and 2,2′-azobis (2-amidinopropane) (AAPH)-induced oxidative stress in human erythrocytes

(2015) Shumin Liu et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease

(2015) Jing-Na Deng et al.   Evidence-based Complementary and Alternative Medicine

Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling

(2015) Lu Lu Wang et al.   HEPATOLOGY RESEARCH

Protective effects of Ginkgo biloba leaf polysaccharide on nonalcoholic fatty liver disease and its mechanisms

(2015) Zhengui Yan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A novel cobiotic-based preventive approach against high-fat diet-induced adiposity, nonalcoholic fatty liver and gut derangement in mice

(2015) D P Singh et al.   INTERNATIONAL JOURNAL OF OBESITY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice

(2015) Aline B. Santamarina et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anthocyanin-rich extracts from blackberry, wild blueberry, strawberry, and chokeberry: antioxidant activity and inhibitory effect on oleic acid-induced hepatic steatosisin vitro

(2015) Yong Wang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine

(2015) Maria Lúcia Bonfleur et al.   LIFE SCIENCES

Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease

(2015) Shobha H. Ganji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

(2015) Sandra Pisonero-Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

(2015) Yong Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease

(2015) Satoshi Wanezaki et al.   Obesity Research & Clinical Practice

A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis

(2015) Laura E. Downing et al.   PLoS One

Flaxseed oil containing flaxseed oil ester of plant sterol attenuates high-fat diet-induced hepatic steatosis in apolipoprotein-E knockout mice

(2015) Hao Han et al.   Journal of Functional Foods

A Green Algae Mixture of Scenedesmus and Schroederiella Attenuates Obesity-Linked Metabolic Syndrome in Rats

(2015) Senthil Kumar et al.   Nutrients

Greater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adults

(2015) Yi Cao et al.   Scientific Reports

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model

(2014) Ming Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Non-alcoholic fatty liver disease: need for a balanced nutritional source

(2014) Jayagopalan Veena et al.   BRITISH JOURNAL OF NUTRITION

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes

(2014) Antonysunil Adaikalakoteswari et al.   Cardiovascular Diabetology

Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?

(2014) B. Li et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Low Serum Concentrations of Carotenoids and Vitamin E Are Associated with High Adiposity in Mexican-American Children

(2014) Inong R. Gunanti et al.   JOURNAL OF NUTRITION

β-Carotene-9′,10′-Oxygenase Status Modulates the Impact of Dietary Tomato and Lycopene on Hepatic Nuclear Receptor–, Stress-, and Metabolism-Related Gene Expression in Mice

(2014) Hsueh-Li Tan et al.   JOURNAL OF NUTRITION

Retinol Status and Expression of Retinol-Related Proteins in Methionine-Choline Deficient Rats

(2014) Hiroshi MIYAZAKI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice

(2014) Ho Sung Lee et al.   LIFE SCIENCES

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

β-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice

(2014) Masuko Kobori et al.   PLoS One

Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease

(2014) Stefano Ballestri   WORLD JOURNAL OF GASTROENTEROLOGY

Does Vitamin C Deficiency Promote Fatty Liver Disease Development?

(2014) David Ipsen et al.   Nutrients

Nutraceuticals and Functional Foods in the Management of Hyperlipidemia

(2013) Gu Chen et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The inhibitory effect of black soybean on hepatic cholesterol accumulation in high cholesterol and high fat diet-induced non-alcoholic fatty liver disease

(2013) Ji-Hye Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study

(2013) RYUICHIRO SAKATA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease

(2013) Marno C. Ryan et al.   JOURNAL OF HEPATOLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

The Effects of α-Lipoic Acid on Liver Oxidative Stress and Free Fatty Acid Composition in Methionine–Choline Deficient Diet-Induced NAFLD

(2013) Milena N. Stanković et al.   JOURNAL OF MEDICINAL FOOD

Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

(2013) João Marcus Oliveira Andrade et al.   NUTRITION

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Hydrogen Sulfide Impairs Glucose Utilization and Increases Gluconeogenesis in Hepatocytes

(2012) Ling Zhang et al.   ENDOCRINOLOGY

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

(2012) Lokpal S. Bhatia et al.   EUROPEAN HEART JOURNAL

Nonalcoholic Fatty Liver Disease

(2012) Stergios A. Polyzos et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

(2012) Anne Leroux et al.   JOURNAL OF HEPATOLOGY

Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet

(2012) Jiyun Ahn et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

(2012) D. Compare et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Lipoic Acid Improves Mitochondrial Function in Nonalcoholic Steatosis Through the Stimulation of Sirtuin 1 and Sirtuin 3

(2012) M. Pilar Valdecantos et al.   Obesity

Retinoids as Promising Treatment for Non-alcoholic Fatty Liver Disease

(2012) Hiroyuki Tsuchiya   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Insulin resistance and the metabolism of branched-chain amino acids in humans

(2011) María M. Adeva et al.   AMINO ACIDS

Plasma Carotenoid Concentrations before and after Supplementation with Astaxanthin in Middle-Aged and Senior Subjects

(2011) Taiki MIYAZAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

(2011) Michele Malaguarnera et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibitory Effect of Blueberry Polyphenolic Compounds on Oleic Acid-Induced Hepatic Steatosis in Vitro

(2011) Yixiang Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Consumption of plant sterols reduces plasma and hepatic triglycerides and modulates the expression of lipid regulatory genes and de novo lipogenesis in C57BL/6J mice

(2010) Todd C. Rideout et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease

(2010) Juan G. Gormaz et al.   PROGRESS IN LIPID RESEARCH

Bioavailability of Astaxanthin inHaematococcusAlgal Extract: The Effects of Timing of Diet and Smoking Habits

(2009) Yumika OKADA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Short chain fatty acids exchange: Is the cirrhotic, dysfunctional liver still able to clear them?

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls

(2009) S. Parish et al.   EUROPEAN HEART JOURNAL

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

β-Carotene and β-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages

(2009) Sakurako Katsuura et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Impact of micronutrient deficiencies on obesity

(2009) Olga P García et al.   NUTRITION REVIEWS

New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism

(2008) Laura Calpe-Berdiel et al.   ATHEROSCLEROSIS

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

(2008) Artemis P. Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis

(2008) Daniel J. Rader et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS