Article
Chemistry, Medicinal
Il Ho Lee, Eunji Im, Hyo-Jung Lee, Deok Yong Sim, Jae Hee Lee, Ji Hoon Jung, Ji Eon Park, Bum Sang Shim, Sung-Hoon Kim
Summary: The study found that honokiol can exert apoptotic and antifibrotic effects by activating GSK3 beta and inhibiting the Wnt3a/beta-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study showed that P2X7R plays an important role in the pathogenesis of STZ-induced diabetic cardiac damage and remodeling through the PKC beta/ERK axis. These findings suggest that P2X7R might be a potential target in the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiu-Qin Li, Wen-Ting Peng, Shan Shan, Jing-Jing Wu, Nan Li, Jia-Jia Du, Jia-Chang Sun, Ting-Ting Chen, Wei Wei, Wu-Yi Sun
Summary: The study revealed that the activation of beta 2-AR in HSCs induces proliferation and migration of HCC cells through Akt signaling, with this effect being regulated by beta-arrestin2. The expression of beta 2-AR was increased while beta-arrestin2 was decreased in HSCs of HCC tissues. Knockout of beta-arrestin2 exacerbated DEN-induced HCC.
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study indicates that P2X7R plays an important role in STZ-induced diabetic cardiac damage and remodeling, and may be a potential target for the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chan Qiu, Yi Liu, Shengjie Huang, Bo Ning, Song He, Li Zhong
Summary: Our study demonstrated that Rab31 could promote hepatic stellate cells activation by accelerating TGF-beta Receptor II complex endocytosis, suggesting that interfering with Rab31 could be an effective strategy to inhibit hepatic fibrosis progression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soonjae Hwang, Sangbin Park, Uzma Yaseen, Ho-Jae Lee, Ji-Young Cha
Summary: Liver fibrosis is a progressive and debilitating disease characterized by excessive deposition of extracellular matrix proteins. Our study reveals that KLF10 acts as a negative regulator of TGF-beta signaling pathway, suppressing hepatic stellate cell activation and fibrogenesis through modulation of ATF3 expression. Targeting the KLF10-ATF3 axis may have therapeutic implications for liver fibrosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Anna Sancho-Balsells, Esther Garcia-Garcia, Francesca Flotta, Wanqi Chen, Jordi Alberch, Manuel J. Rodriguez, Conxita Avila, Albert Giralt
Summary: This study suggests that Meridianins could be a promising therapeutic tool for stress-related disorders such as major depression disorder. Meridianins can inhibit GSK3 beta activity in multiple brain regions associated with stress-related symptoms and produce therapeutic effects by altering signaling pathways and increasing synaptic activity.
Article
Biochemistry & Molecular Biology
Kuo-Yun Tseng, Ko-Hung Liu, Hung-Ming Wu, Shankung Lin
Summary: This study revealed the selective effect of FASN inhibitor C75 on adipogenesis and identified cell-type-specific adenosine receptor expression as a possible explanation for the differential adipogenic effects of C75.
Article
Immunology
Fangming Yang, Heng Li, Yanmin Li, Yaokun Hao, Chenxiao Wang, Pan Jia, Xinju Chen, Suping Ma, Zhun Xiao
Summary: Hepatic fibrosis is a dynamic pathological process characterized by the accumulation of extra cellular matrix in chronic liver diseases, with activation of hepatic stellate cells (HSCs) playing a central role. Communication between hepatocytes and surrounding cells influences the activation of HSCs and the progression of fibrosis, highlighting the complexity and plasticity of HSC activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ruoyu Wang, Dong Zhang, Dan Tang, Kewei Sun, Jianping Peng, Wenfang Zhu, Sihan Yin, Yunan Wu
Summary: Amygdalin effectively suppressed the activation of hepatic stellate cells induced by TGF-beta 1 by modulating proliferation, fibrogenesis, and inflammation signaling pathways in vitro, leading to improvement in liver fibrosis and damage in a CCl4-stimulated rat model in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maximilian Schinagl, Tamara Tomin, Juergen Gindlhuber, Sophie Honeder, Raphael Pfleger, Matthias Schittmayer, Michael Trauner, Ruth Birner-Gruenberger
Summary: This study investigated the activation of hepatic stellate cells (HSC) through an increase in growth medium serum concentration, revealing cellular processes involved in HSC transformation. Activated HSC showed increased production of ribosomal proteins and proteins related to migration and cell cycle control, along with a decrease in cholesterol and fatty acid biosynthesis proteins. The findings provide insights into HSC activation characteristics and present a accessible model for studying HSC activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yana Geng, Junyu Wang, Sandra Alejandra Serna-Salas, Alejandra Hernandez Villanueva, Manon Buist-Homan, Marco Arrese, Peter Olinga, Hans Blokzijl, Han Moshage
Summary: Liver fibrosis is a response of the liver to chronic inflammation. Hepatic stellate cells (HSCs) can induce the inflammatory phenotype in liver macrophages (KCs) through the release of extracellular vesicles (EVs), thereby promoting fibrosis. This effect is mediated by the activation of Toll-like receptor 4 (TLR4) signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengchao Yan, Ye Xie, Jia Yao, Xun Li
Summary: This study investigates the correlation between alpha-SMA expression and collagen secretion in liver fibrosis, proposing a dual-mode transition model for myofibroblasts in fibrotic liver. The model reasonably explains collagen deposition and expansion in the initial stage of liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Fiona Limanaqi, Carla L. Busceti, Roberta Celli, Francesca Biagioni, Francesco Fornai
Summary: Autophagy is crucial for maintaining cell proteostasis and plays a key role in neurotransmitter release, synaptic plasticity, and neuronal survival. Dysfunction in autophagy is associated with synaptic alterations seen in mental disorders and early stages of neurodegenerative diseases. Methamphetamine abuse disrupts the autophagy machinery, leading to behavioral changes and neurotoxic effects through altered dopamine release and neuroinflammatory events.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Neurosciences
Dakota R. Kamm, Kyle S. McCommis
Summary: Hepatic stellate cells (HSCs) play critical roles in the normal liver and in response to injury. They are activated during liver injury and produce extracellular matrix in liver fibrosis. In the absence of injury, HSCs are in a quiescent state and store retinoids or vitamin A-containing metabolites. They also enhance the inflammatory response and express growth factors crucial for liver development and regeneration. Recent studies have identified diverse phenotypic alterations and unique subpopulations of HSCs.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Cell Biology
Sheng Wang, Songsen Gao, Dexi Zhou, Xueyi Qian, Jiajie Luan, Xiongwen Lv
Summary: Extracellular ATP serves as a danger signal released by dying and damaged cells, promoting inflammation as an immunostimulatory signal. CD39 and CD73 play critical roles in liver disease by breaking down ATP into adenosine, shifting from a proinflammatory to an anti-inflammatory environment. The modification of the CD39-CD73-adenosine pathway alters the liver's response to injury and adenosine exerts different effects on liver pathophysiology through different receptors.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wen-qian Jia, Tao-cheng Zhou, Jing-wen Dai, Zhen-ni Liu, Ya-fei Zhang, Dan-dan Zang, Xiong-wen Lv
Summary: The study reveals the role of CD73 in HSC activation and suggests that the Wnt/beta-catenin signaling pathway may be involved in this progression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Nursing
Ting-Yu Mu, Yu-Hong Li, Ri-Xiang Xu, Jun Chen, Ya-Ya Wang, Cui-Zhen Shen
Summary: This study aimed to determine the efficacy of Internet-based interventions in reducing postpartum depression in perinatal women. Most of the reviewed studies showed that Internet-based interventions significantly improved postpartum depression. However, there were differences in attrition rates between the intervention and control groups.
Article
Pharmacology & Pharmacy
Chen Shuai, Guo-qing Xia, Fei Yuan, Sheng Wang, Xiong-wen Lv
Summary: CD39 plays a role in alcoholic liver disease by regulating HSC activation and fibrosis development, and its blockade can prevent these processes. The findings suggest that ATP-adenosine signaling is a novel therapeutic target for alcoholic liver disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Sheng Wang, Songsen Gao, Yueran Li, Xueyi Qian, Jiajie Luan, Xiongwen Lv
Summary: Chemokine receptors are crucial in regulating cellular functions and immune processes. Among them, CXCR4 plays a key role in liver disease pathogenesis by influencing cell migration through significant signaling pathways. Understanding the CXCR4-mediated signaling pathway is essential for identifying potential therapeutic strategies in liver disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ting-Yu Mu, Ri-Xiang Xu, Jia-Yi Xu, Die Dong, Zhi-Nan Zhou, Jia-Ning Dai, Cui-Zhen Shen
Summary: This study examined the associations between different types of self-care disability, the number of self-care disabilities, and depressive symptoms among middle-aged and elderly Chinese people. The results showed a significant positive association between self-care disability and depressive symptoms. Participants with a greater cumulative quantity of self-care disabilities had a higher risk of depressive symptoms.
Article
Chemistry, Medicinal
Zhen-Ni Liu, Qian-Qian Su, Yu-Hui Wang, Xue Wu, Xiong-Wen Lv
Summary: This study finds that P2Y2R plays an important role in regulating alcoholic liver inflammation by targeting the EGFR-ERK1/2 signaling pathway and hepatocyte apoptosis, which may provide new ideas for the development of methods to treat ALD.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Gastroenterology & Hepatology
Guo-Qing Xia, Qian Fang, Jun-Nan Cai, Zi-Xuan Li, Feng-Zhi Zhang, Xiong-Wen Lv
Summary: This article briefly reviews the role of the P2X7R-NLRP3 inflammasome axis in the pathogenesis and progression of alcoholic liver disease, and suggests regulating this inflammasome axis as a new approach for its treatment.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rixiang Xu, Yulian Liu, Tingyu Mu, Yaping Ye, Caiming Xu
Summary: This study examines the association between different living arrangements and depressive symptoms among Chinese people over 65 years old. It found that older people living alone or in eldercare institutions have a higher risk of depressive symptoms and that outdoor activities can moderate this relationship.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Tingyu Mu, Rixiang Xu, Qianyin Zhu, Lingshan Chen, Die Dong, Jiayi Xu, Cuizhen Shen
Summary: This study investigated the diet-related knowledge, attitudes, and behaviors among young and middle-aged individuals with high-normal blood pressure in China. The results showed that individuals with a higher level of education, proactive in seeking nutrition knowledge, and those who liked to eat vegetables were more likely to have sufficient dietary knowledge literacy. High school/vocational education, college degree or above, knowledge about the Chinese Food Pagoda or Dietary Guidelines for Chinese Residents, and sufficient dietary knowledge literacy were associated with an increased likelihood of looking for nutrition knowledge.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, Research & Experimental
Sheng Wang, Songsen Gao, Wufei Ye, Yueran Li, Jiajie Luan, Xiongwen Lv
Summary: N6-methyladenosine (m6A) modification is a common type of inner RNA modification in eukaryotes, playing various roles in normal and abnormal biological processes. It is modulated by m6A writer, eraser, and reader, and impacts RNA metabolism processes such as processing, translation, export, localization, and decay. The potential molecular mechanism and specific role of m6A modification in liver disease are not fully understood. In this review, we summarize the latest research progress on m6A modification in liver disease and explore its impact on RNA metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Guoqing Xia, Zixuan Li, Xiaodong Sheng, Zhongwen Xie, Qian Fang, Cheng Zhang, Tiantian Wang, Yulian Wang, Baoming Wu, Xiongwen Lv
Summary: This study investigates the potential mechanism of green tea water extract (GTWE) in treating alcohol-related hepatitis (ARH) through network pharmacology, molecular docking, and experimental validation. The study identifies active components and potential targets of GTWE, with TLR4 being confirmed as the central target. Experimental findings demonstrate that GTWE effectively mitigates alcohol-induced liver and intestinal inflammation and microbiota disturbance. GTWE shows considerable potential as a pharmacological intervention for ARH.
Article
Health Care Sciences & Services
Rixiang Xu, Tingyu Mu, Wang Jian, Caiming Xu, Jing Shi
Summary: The study assessed knowledge, attitude, and prescription practices regarding antimicrobials among physicians in Zhejiang province, China. Findings showed that younger general practitioners with less training were more likely to over-prescribe antimicrobials, while older physicians with more training were more likely to provide correct knowledge and avoid unnecessary prescriptions. Proper prescription of antimicrobials depends on physicians' knowledge and continuous training programs.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2021)
Review
Gastroenterology & Hepatology
Guo-Qing Xia, Qian Fang, Jun-Nan Cai, Zi-Xuan Li, Feng-Zhi Zhang, Xiong-Wen Lv
Summary: Alcoholic liver disease is a common chronic liver disease caused by prolonged heavy drinking, characterized by nausea, vomiting, enlargement of the liver, and jaundice. Recent studies suggest that Kupffer cell-mediated inflammatory response plays a key role in the development of alcoholic steatohepatitis and alcoholic liver fibrosis. Regulating the P2X7R-NLRP3 inflammasome axis may offer a new approach for treating alcoholic liver disease.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)