期刊
JOURNAL OF FUNCTIONAL FOODS
卷 23, 期 -, 页码 294-305出版社
ELSEVIER
DOI: 10.1016/j.jff.2016.02.041
关键词
Adenosine monophosphate activated protein kinase; Eicosapentaenoic acid-containing phosphatidylcholine; Non-alcoholic fatty liver disease; Peroxisome proliferators activated receptor alpha; Sterol regulatory element binding protein-1c
资金
- National Natural Science Foundation of China [31330060]
- Science and Technology Development Plan of Shandong Province [2012CX80201]
- National Science & Technology Pillar Program during the 12th Five-year Plan Period [2012BAD33B07]
- College of Food Science and Engineering, Ocean University of China
The lipid-lowering effects of eicosapentaenoic acid-containing phosphatidylcholine (EPA-PC) from sea cucumber in rat models of non-alcoholic fatty liver disease (NAFLD) were investigated. Oral administration of EPA-PC to orotic acid (OA)-fed mice lowered the liver to-body weight ratio, serum and hepatic triacylglycerol (TG) and total cholesterol (TC) levels, and high-density lipoprotein cholesterol (HDLC)/TC ratio. EPA-PC also increased the proportion of polyunsaturated fatty acids (PUFA) in serum and hepatic lipids. To elucidate the possible mechanism of action underlying the lipid-lowering effects of EPA-PC, the key enzymes and transcriptional factors involved in fatty acid biosynthesis, transport, and beta-oxidation were investigated. The mRNA expressions of SREBP-1c, PPAR alpha, and AMPK, as well as of their target genes, were detected. The results showed that EPA-PC could significantly ameliorate lipid accumulation by suppressing lipid biosynthesis and promoting fatty acid transport and beta-oxidation. Overall, our findings revealed that EPA-PC could alleviate NAFLD. (C) 2016 Elsevier Ltd. All rights reserved.
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