Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders

(2017) Soumia Fenni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

(2017) Liang Xiao et al.   Microbiome

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

(2016) Sarmistha Mukherjee et al.   HEPATOLOGY

Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism

(2016) Grzegorz Palczewski et al.   JOURNAL OF LIPID RESEARCH

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

(2016) Yueli Tian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Association between Dietary Vitamin C Intake and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Middle-Aged and Older Adults

(2016) Jie Wei et al.   PLoS One

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Influence of high-fat diet on gut microbiota

(2015) E. Angela Murphy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

(2015) RAM Luvizotto et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease

(2015) Tanya M. Monaghan et al.   INFLAMMATORY BOWEL DISEASES

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

(2015) Weiwei Jiang et al.   Scientific Reports

Changes in Gut Microbiota in Rats Fed a High Fat Diet Correlate with Obesity-Associated Metabolic Parameters

(2015) Virginie Lecomte et al.   PLoS One

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease

(2015) Sanja Stojsavljević   WORLD JOURNAL OF GASTROENTEROLOGY

Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

(2014) Zongxin Ling et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Lycopene Attenuated Hepatic Tumorigenesis via Differential Mechanisms Depending on Carotenoid Cleavage Enzyme in Mice

(2014) B. C. Ip et al.   Cancer Prevention Research

Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?

(2014) Fionn Murtagh et al.   JOURNAL OF CLASSIFICATION

High-Refined–Carbohydrate and High-Fat Diets Induce Comparable Hepatic Tumorigenesis in Male Mice

(2014) Blanche C. Ip et al.   JOURNAL OF NUTRITION

Lycopene and Apo-10′-lycopenoic Acid Have Differential Mechanisms of Protection against Hepatic Steatosis in β-Carotene-9′,10′-oxygenase Knockout Male Mice

(2014) Blanche C Ip et al.   JOURNAL OF NUTRITION

Intestinal and Systemic Inflammatory Responses Are Positively Associated with Sulfidogenic Bacteria Abundance in High-Fat–Fed Male C57BL/6J Mice

(2014) Wan Shen et al.   JOURNAL OF NUTRITION

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver

(2013) Romana R. Gerner et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice

(2013) B. C. Ip et al.   Cancer Prevention Research

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

(2013) Brian W. Parks et al.   Cell Metabolism

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

(2013) S. Imai et al.   DIABETES OBESITY & METABOLISM

Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing

(2013) S.-W. Kim et al.   DNA RESEARCH

Substrate Specificity of Purified Recombinant Human β-Carotene 15,15′-Oxygenase (BCO1)

(2013) Carlo dela Seña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cordycepin activates AMP-activated protein kinase (AMPK)viainteraction with the γ1 subunit

(2013) Chongming Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

(2013) Carmine Finelli   WORLD JOURNAL OF GASTROENTEROLOGY

Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention

(2013) Blanche Ip et al.   Nutrients

PPAR-α as a Key Nutritional and Environmental Sensor for Metabolic Adaptation

(2013) Alejandra V. Contreras et al.   Advances in Nutrition

Lycopene metabolism and its biological significance

(2012) Xiang-Dong Wang   AMERICAN JOURNAL OF CLINICAL NUTRITION

Tomato juice consumption reduces systemic inflammation in overweight and obese females

(2012) Mahsa Ghavipour et al.   BRITISH JOURNAL OF NUTRITION

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

(2012) Ana Paula Boroni Moreira et al.   BRITISH JOURNAL OF NUTRITION

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations

(2012) Chenhong Zhang et al.   ISME Journal

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Apo-10'-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice

(2012) Jayong Chung et al.   JOURNAL OF NUTRITION

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Role of SIRT1-FoxO1 Signaling in Dietary Saturated Fat-Dependent Upregulation of Liver Adiponectin Receptor 2 in Ethanol-Administered Mice

(2011) Xiaomei Liang et al.   ANTIOXIDANTS & REDOX SIGNALING

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Gut microbiome, obesity, and metabolic dysfunction

(2011) Herbert Tilg et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

Single Nucleotide Polymorphisms Upstream from the β-Carotene 15,15'-Monoxygenase Gene Influence Provitamin A Conversion Efficiency in Female Volunteers

(2011) Georg Lietz et al.   JOURNAL OF NUTRITION

Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction

(2011) Shaheen E Lakhan et al.   Journal of Translational Medicine

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

(2010) Darren L. Roberts et al.   Annual Review of Medicine

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

The role of inflamed adipose tissue in the insulin resistance

(2010) Francisco L. Torres-Leal et al.   CELL BIOCHEMISTRY AND FUNCTION

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes

(2010) Alexander Wree et al.   DIGESTION

Interleukin-1β May Mediate Insulin Resistance in Liver-Derived Cells in Response to Adipocyte Inflammation

(2010) Ori Nov et al.   ENDOCRINOLOGY

Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation

(2010) Fen Xu et al.   ENDOCRINOLOGY

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Identification and Quantification of Apo-lycopenals in Fruits, Vegetables, and Human Plasma

(2010) Rachel E. Kopec et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL

An Update on the Health Effects of Tomato Lycopene

(2010) Erica N. Story et al.   Annual Review of Food Science and Technology

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Common Variation in the β-Carotene 15,15′-Monooxygenase 1 Gene Affects Circulating Levels of Carotenoids: A Genome-wide Association Study

(2009) Luigi Ferrucci et al.   AMERICAN JOURNAL OF HUMAN GENETICS

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

NASH and HCC

(2009) John M. Page et al.   Clinics in Liver Disease

The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease

(2009) Stergios A. Polyzos et al.   DIABETES OBESITY & METABOLISM

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats

(2009) Yan Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

Mechanisms for the anti-inflammatory effects of adiponectin in macrophages

(2008) Honglian Huang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL