标题
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 30, Issue 6, Pages 389-407
出版商
Informa UK Limited
发表日期
2020-03-31
DOI
10.1080/13543776.2020.1749264
参考文献
相关参考文献
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- SIRT5 regulation of ammonia-induced autophagy and mitophagy
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- Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease
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- Human SIRT3 tripeptidic inhibitors containing Nε-thioacetyl-lysine
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- Tumour-suppressive function of SIRT4 in human colorectal cancer
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- An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease
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- Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia
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- Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
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- SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
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- A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
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- The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
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- New assays and approaches for discovery and design of Sirtuin modulators
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- A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
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- SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
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- SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?
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- The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
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- The Identification of the SIRT1 Activator SRT2104 as a Clinical Candidate
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- Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis
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- An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms
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- Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration
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- Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells
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- SIRT1 Protects against -Synuclein Aggregation by Activating Molecular Chaperones
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- SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
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- Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
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- The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models
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- Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
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- Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
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- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
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- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
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- SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
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- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
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- Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues
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