MLKL in cancer: more than a necroptosis regulator

Cell adhesion in cancer: Beyond the migration of single cells

(2020) Michalina Janiszewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection

(2020) Tania Løve Aaes et al.   JOURNAL OF IMMUNOLOGY

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

(2020) Yohei Ando et al.   PLoS One

RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events

(2020) Tom Delanghe et al.   TRENDS IN CELL BIOLOGY

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

(2020) Ha Thi Thu Do et al.   Cancers

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

(2020) Xiaoqin Wu et al.   JOURNAL OF HEPATOLOGY

Tumours use NETs as physical shields

(2020) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression

(2020) Jialin Dai et al.   Cell Death & Disease

Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model

(2020) Jingyuan Li et al.   Cell Death & Disease

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

(2020) Katherine A. Davies et al.   Nature Communications

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

(2020) Joanne M. Hildebrand et al.   Nature Communications

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration

(2020) Shen’ao Zhou et al.   CELL RESEARCH

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

(2020) Silvia Alvarez-Diaz et al.   CELL DEATH AND DIFFERENTIATION

Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis

(2020) Martin Rübbelke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression

(2019) Yu Xiong et al.   CELL DEATH AND DIFFERENTIATION

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

(2019) Daniel Frank et al.   JOURNAL OF CELL SCIENCE

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

Complex roles of necroptosis in cancer

(2019) Fang Zhu et al.   Journal of Zhejiang University-SCIENCE B

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

(2019) Selma Maacha et al.   Molecular Cancer

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

(2019) Liu Han et al.   Molecular Cancer

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

(2019) Ayaz Najafov et al.   MOLECULAR CELL

Upregulated necroptosis-pathway-associated genes are unfavorable prognostic markers in low-grade glioma and glioblastoma multiforme

(2019) Yuanli Dong et al.   Translational Cancer Research

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis

(2019) Hila Doron et al.   Cell Reports

Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer

(2019) Colin Sheehan et al.   JOURNAL OF CELL SCIENCE

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

(2019) Jean M. Mulcahy Levy et al.   CELL DEATH AND DIFFERENTIATION

Depletion of MLKL inhibits invasion of radioresistant nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition

(2019) Yuanli Dong et al.   Annals of Translational Medicine

Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis

(2018) Binwu Hu et al.   BMC CANCER

MLKL-PITPα signaling-mediated necroptosis contributes to cisplatin-triggered cell death in lung cancer A549 cells

(2018) Lin Jing et al.   CANCER LETTERS

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy

(2018) Ryuma Tokunaga et al.   CANCER TREATMENT REVIEWS

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

(2018) Joseph Sarhan et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis

(2018) Delong Jiao et al.   CELL RESEARCH

Low Necroptosis Process Predicts Poor Treatment Outcome of Human Papillomavirus Positive Cervical Cancers by Decreasing Tumor-Associated Macrophages M1 Polarization

(2018) Lin Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

(2018) Cole M. Dovey et al.   MOLECULAR CELL

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis

(2018) Shuo Liu et al.   Cell Death & Disease

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

Interferon-β deficiency at asthma exacerbation promotes MLKL mediated necroptosis

(2018) Samuel C. Cerps et al.   Scientific Reports

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

(2018) Akshay A. D’Cruz et al.   Science Signaling

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

The Structural Basis of Necroptotic Cell Death Signaling

(2018) Emma J. Petrie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

(2018) Anne-Kathrin Knuth et al.   NEOPLASIA

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

Relevance of necroptosis in cancer

(2017) Najoua Lalaoui et al.   IMMUNOLOGY AND CELL BIOLOGY

Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo

(2017) Dan Sun et al.   JOURNAL OF DRUG TARGETING

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

(2017) Kimberley D. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

(2017) Kay Hänggi et al.   Cell Death & Disease

Distinct Kinase-Independent Role of RIPK3 in CD11c + Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

(2017) Kenta Moriwaki et al.   Cell Reports

Pro-necrotic molecules impact local immunosurveillance in human breast cancer

(2017) Gautier Stoll et al.   OncoImmunology

Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis

(2017) Seung Hoon Lee et al.   Scientific Reports

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

(2016) Ulrike Höckendorf et al.   CANCER CELL

Killing AML: RIPK3 leads the way

(2016) Ulrike Höckendorf et al.   CELL CYCLE

Evolutionary divergence of the necroptosis effector MLKL

(2016) M C Tanzer et al.   CELL DEATH AND DIFFERENTIATION

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

(2016) Zhenyu Cai et al.   CELL RESEARCH

Molecular Pathways: The Necrosome—A Target for Cancer Therapy

(2016) Lena Seifert et al.   CLINICAL CANCER RESEARCH

The untold story of IFN-γ in cancer biology

(2016) M. Alper Kursunel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway

(2016) J Xin et al.   LEUKEMIA

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

(2016) Xian Li et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner

(2016) Zhai Ertao et al.   TUMOR BIOLOGY

Key roles of necroptotic factors in promoting tumor growth

(2016) Xinjian Liu et al.   Oncotarget

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy

(2016) Heng Yang et al.   OncoImmunology

Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas

(2016) Crystal S Seldon et al.   World Journal of Gastrointestinal Oncology

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

(2015) M. C. Tanzer et al.   BIOCHEMICAL JOURNAL

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it

(2015) S Yoon et al.   CELL DEATH AND DIFFERENTIATION

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity

(2015) Guiquan Zhu et al.   Oncotarget

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

(2014) S. McComb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

(2014) A-L Nugues et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma

(2013) Lauren E. Colbert et al.   CANCER

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection

(2009) A.-D. C. Chessler et al.   JOURNAL OF IMMUNOLOGY