期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 20, 期 5, 页码 399-413出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1900160
关键词
Cell death; Necroptosis; Cancer; Mixed lineage kinase domain-like protein (MLKL); Receptor-interacting protein (RIP) kinase
类别
资金
- National Natural Science Foundation of China [31671436, 31600133, 31771533, 31830051]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Natural Science Foundation of Jiangsu Province [BK20160314]
- Fok Ying Tung Education Foundation for Young Teachers [151020]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2017NL31002, 2017NL31004]
Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed lineage kinase domain-like protein (MLKL). Because of membrane rupture, necroptotic cells release damage-associated molecular patterns (DAMPs) that evoke immune responses. Necroptosis is emerging as an important cellular response in the modulation of cancer initiation, progression, and metastasis. Necroptosis of cancer cells is considered to be an immunogenic cell death capable of activating anti-tumor immunity. Necroptosis also participates in the promotion of myeloid cell-induced adaptive immune suppression and thus contributes to oncogenesis. In addition, necroptosis of endothelial cells and tumor cells is conducive to tumor metastasis. In this review, we summarize the current knowledge of the complex role of necroptosis in cancer and discuss the potential of targeting necroptosis components for cancer therapies.
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