Small heat shock proteins: multifaceted proteins with important implications for life

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins

(2018) Tomas Grousl et al.   JOURNAL OF CELL BIOLOGY

Using Single-Molecule Approaches to Understand the Molecular Mechanisms of Heat-Shock Protein Chaperone Function

(2018) Caitlin L. Johnston et al.   JOURNAL OF MOLECULAR BIOLOGY

Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3

(2018) Alice R. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Small heat shock protein B3 (HSPB3 ) mutation in an axonal Charcot-Marie-Tooth disease family

(2018) Da E. Nam et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis

(2018) Afrooz Dabbaghizadeh et al.   PLoS One

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions

(2018) Georg K. A. Hochberg et al.   SCIENCE

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

Small heat shock proteins: Simplicity meets complexity

(2018) Martin Haslbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal loading of a small heat shock protein increases embryo thermal tolerance inDrosophila melanogaster

(2017) Brent L. Lockwood et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The chaperone toolbox at the single-molecule level: From clamping to confining

(2017) Mario J. Avellaneda et al.   PROTEIN SCIENCE

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function

(2017) Federica F. Morelli et al.   Cell Reports

Granulostasis: Protein Quality Control of RNP Granules

(2017) Simon Alberti et al.   Frontiers in Molecular Neuroscience

The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

(2016) M. Madan Babu   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure and function of α-crystallins: Traversing from in vitro to in vivo

(2016) Martin Haslbeck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis

(2016) Ah-Mee Park et al.   PLoS One

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

(2016) D. R. Whiten et al.   Scientific Reports

A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers

(2015) Scott P. Delbecq et al.   BIOCHEMISTRY

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

The environmentally tuned transcriptomes of Mytilus mussels

(2015) B. L. Lockwood et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes

(2015) Tilly Fleckenstein et al.   MOLECULAR CELL

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations inHSPB8causing a new phenotype of distal myopathy and motor neuropathy

(2015) Roula Ghaoui et al.   NEUROLOGY

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome

(2015) Julianne H. Grose et al.   PLoS One

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

(2014) S J Seguin et al.   CELL DEATH AND DIFFERENTIATION

MobiDB 2.0: an improved database of intrinsically disordered and mobile proteins

(2014) Emilio Potenza et al.   NUCLEIC ACIDS RESEARCH

HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

(2014) André-Patrick Arrigo et al.   Cancers

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

One size does not fit all: The oligomeric states of αB crystallin

(2013) Scott P. Delbecq et al.   FEBS LETTERS

Reshaping of the conformational search of a protein by the chaperone trigger factor

(2013) Alireza Mashaghi et al.   NATURE

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Regulated structural transitions unleash the chaperone activity of  B-crystallin

(2013) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The oligomer plasticity of the small heat-shock protein Lo18 fromOenococcus oeniinfluences its role in both membrane stabilization and protein protection

(2012) Magali Maitre et al.   BIOCHEMICAL JOURNAL

Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal Domain

(2012) Ezelle T. McDonald et al.   BIOCHEMISTRY

Order out of Disorder: Working Cycle of an Intrinsically Unfolded Chaperone

(2012) Dana Reichmann et al.   CELL

HspB1 Dynamic Phospho-Oligomeric Structure Dependent Interactome as Cancer Therapeutic Target

(2012) A.-P. Arrigo et al.   CURRENT MOLECULAR MEDICINE

The Role of Intrinsically Disordered Regions in the Structure and Functioning of Small Heat Shock Proteins

(2012) Maria V. Sudnitsyna et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Cohort Profile: The Dongfeng–Tongji cohort study of retired workers

(2012) Feng Wang et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice

(2012) Takahiro Ishiwata et al.   PLoS One

Exploring the limit of metazoan thermal tolerance via comparative proteomics: thermally induced changes in protein abundance by two hydrothermal vent polychaetes

(2012) G. F. Dilly et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer

(2011) Tomoko Oya-Ito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

(2011) J. Eric Ahlskog et al.   MAYO CLINIC PROCEEDINGS

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Functional Promoter −1271G>C Variant ofHSPB1Predicts Lung Cancer Risk and Survival

(2010) Huan Guo et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcriptomic responses to heat stress in invasive and native blue mussels (genus Mytilus): molecular correlates of invasive success

(2010) B. L. Lockwood et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Mutant small heat shock protein B3 causes motor neuropathy: Utility of a candidate gene approach

(2010) S. J. Kolb et al.   NEUROLOGY

Heat shock response of killifish (Fundulus heteroclitus): candidate gene and heterologous microarray approaches

(2010) Timothy M. Healy et al.   PHYSIOLOGICAL GENOMICS

Nature's molecular sponges: Small heat shock proteins grow into their chaperone roles

(2010) S. J. Eyles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/Reperfusion Injury by Suppressed Autophagy and Increased Cell Death

(2009) Jiang Qian et al.   CIRCULATION RESEARCH

Substrate binding site flexibility of the small heat shock protein molecular chaperones

(2009) N. Jaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins

(2008) Anisha A. Gupte et al.   JOURNAL OF APPLIED PHYSIOLOGY

Insights into Small Heat Shock Protein and Substrate Structure during Chaperone Action Derived from Hydrogen/Deuterium Exchange and Mass Spectrometry

(2008) Guilong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mutant Small Heat Shock Protein with Increased Thylakoid Association Provides an Elevated Resistance Against UV-B Damage inSynechocystis6803

(2008) Zsolt Balogi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON