Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

(2014) Parul Mishra et al.   MOLECULAR CELL

Hsp90-Dependent Assembly of the DBC2/RhoBTB2-Cullin3 E3-Ligase Complex

(2014) Jacob R. Manjarrez et al.   PLoS One

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Structural and functional differences of cytosolic 90-kDa heat-shock proteins (Hsp90s) in Arabidopsis thaliana

(2013) Joon-Yung Cha et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer

(2012) T. Shimamura et al.   CLINICAL CANCER RESEARCH

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Solubility-Promoting Function of Hsp90 Contributes to Client Maturation and Robust Cell Growth

(2012) Natalie W. Pursell et al.   EUKARYOTIC CELL

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

(2012) Christian N. Cunningham et al.   PROTEIN SCIENCE

Approaches for defining the Hsp90-dependent proteome

(2011) Steven D. Hartson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

(2010) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Hsf1 activity by novobiocin and geldanamycin

(2009) Renaud Conde et al.   Biochemistry and Cell Biology

A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein

(2009) Jacob J. Gano et al.   MOLECULAR & CELLULAR PROTEOMICS

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

(2009) Yunchen Gong et al.   Molecular Systems Biology

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

(2009) Shinji Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A comparison of Hsp90α and Hsp90β interactions with cochaperones and substrates

(2008) Aliakbar Taherian et al.   Biochemistry and Cell Biology

Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

(2008) Daniel R. Southworth et al.   MOLECULAR CELL

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells

(2008) C M McKinnon et al.   ONCOGENE

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

(2008) A. Yano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA