c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

(2020) Zhibiao Bai et al.   Aging-US

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells

(2020) Mi Wang et al.   JOURNAL OF ANATOMY

Chemerin/CMKLR1 Axis Promotes Inflammation and Pyroptosis by Activating NLRP3 Inflammasome in Diabetic Cardiomyopathy Rat

(2020) Yebin Xie et al.   Frontiers in Physiology

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

(2020) Yifan Jia et al.   Redox Biology

Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

(2020) Qing Zeng et al.   Frontiers in Cellular Neuroscience

27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

(2019) Si Chen et al.   Frontiers in Molecular Neuroscience

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

(2019) Alexey Pronin et al.   Frontiers in Molecular Neuroscience

AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model

(2019) Xuyang Wang et al.   LIFE SCIENCES

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury

(2019) Stephanie W. Lee et al.   Journal of Neuroinflammation

Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases

(2019) Anna M Gram et al.   EMBO JOURNAL

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway

(2019) Changliang He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis

(2019) Pengpeng An et al.   LIFE SCIENCES

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

(2019) Nathalia M. de Vasconcelos et al.   Cold Spring Harbor Perspectives in Biology

EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

(2019) Yuhua Chen et al.   Frontiers in Molecular Neuroscience

Inflammasome signaling and regulation of interleukin-1 family cytokines

(2019) Amy H. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Effectiveness of Huai Qi Huang Granules on Juvenile Collagen-induced Arthritis and Its Influence on Pyroptosis Pathway in Synovial Tissue

(2019) Ting He et al.   Current Medical Science

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

(2019) Xueliang Chen et al.   Cell Death & Disease

AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice

(2018) Jinyu Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells

(2018) Yunhua Zang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of pyroptosis in normal cardiac response to calorie restriction and starvation

(2018) Zhonghua Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression

(2018) Zhen Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Down-regulation of intracellular anti-apoptotic proteins, particularly c-FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL

(2018) Ali Hassanzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

(2018) Shuchao Wang et al.   Frontiers in Cellular Neuroscience

A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis

(2018) Gang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons

(2018) Shuchao Wang et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

(2018) Mohammad Harun-Or-Rashid et al.   Journal of Neuroinflammation

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

(2018) Alessandra Fiore et al.   Nature Communications

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

(2017) M. Elizabeth Fini et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Targeting Circulating Leukocytes and Pyroptosis During Ex Vivo Lung Perfusion Improves Lung Preservation

(2017) Kentaro Noda et al.   TRANSPLANTATION

c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity

(2017) Carlos Plaza-Sirvent et al.   Cell Reports

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure

(2017) Shuchao Wang et al.   PLoS One

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Inflammasome Involvement in Alzheimer’s Disease

(2016) Ingar Olsen et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis

(2016) Shuang Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

The Toxic Effect of ALLN on Primary Rat Retinal Neurons

(2016) Na Li et al.   NEUROTOXICITY RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure

(2014) Lei Shang et al.   BMC NEUROSCIENCE

Erythropoietin Exerts a Neuroprotective Function Against Glutamate Neurotoxicity in Experimental Diabetic Retina

(2014) L. Gu et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response

(2013) Ju-Fang Huang et al.   BMC NEUROSCIENCE

Glaucoma

(2013) A. King et al.   BMJ-British Medical Journal

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY