RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

(2019) Monika Řehořová et al.   Stem Cells Translational Medicine

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

(2019) Biji Mathew et al.   BIOMATERIALS

Proof of Concept for a Portable Platform for Molecular Diagnosis of Tropical Diseases

(2019) Rita C.P. Rampazzo et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

(2019) Ayaz Najafov et al.   MOLECULAR CELL

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis

(2019) Shuchao Wang et al.   Frontiers in Cellular Neuroscience

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

(2019) Susana L. Orozco et al.   Cell Reports

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

(2019) Xixi Zhang et al.   Nature Communications

Antioxidant cascades confer neuroprotection in ethanol, morphine, and methamphetamine preconditioning

(2019) Shuang Lu et al.   NEUROCHEMISTRY INTERNATIONAL

De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif

(2018) Andrew M. Kidger et al.   FEBS Journal

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression

(2018) Zhen Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MTOR Suppresses Cigarette Smoke–Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease

(2018) Yong Wang et al.   JOURNAL OF IMMUNOLOGY

Integrating phosphoproteomics into kinase-targeted cancer therapies in precision medicine

(2018) Xiaomo Wu et al.   Journal of Proteomics

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

Regulatory role of calpain in neuronal death

(2018) Kun Xiong et al.   Neural Regeneration Research

Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

(2018) Shuchao Wang et al.   Frontiers in Cellular Neuroscience

Progress in studies of necroptosis and its relationship to disease processes

(2018) Zhen Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons

(2018) Shuchao Wang et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis

(2018) Zheng Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neuronal apoptosis, axon damage and synapse loss occur synchronously in acute ocular hypertension

(2018) Lan Zhou et al.   EXPERIMENTAL EYE RESEARCH

Receptor-interacting protein kinase 3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice

(2017) Tetsuya Honda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma

(2017) Lucia Cabal-Hierro et al.   MOLECULAR CANCER RESEARCH

Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signaling for cell proliferation

(2017) Nam Hoon Kwon et al.   RNA Biology

RIPK3 promotes adenovirus type 5 activity

(2017) Melanie Weigert et al.   Cell Death & Disease

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

(2017) Zhentao Yang et al.   Cell Reports

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

(2017) Dianrong Li et al.   eLife

Functional Basis and Biophysical Approaches to Characterize the C-Terminal Domain of Human—Ribosomal S6 Kinases-3

(2016) Bhanu P. Jagilinki et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy

(2016) Deyan Kong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis

(2016) Shuang Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome

(2016) Catherine L. Passariello et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer

(2016) Noufira Poomakkoth et al.   Journal of Translational Medicine

CYLD Promotes TNF-α-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells

(2016) Xing Lin et al.   MEDIATORS OF INFLAMMATION

The Toxic Effect of ALLN on Primary Rat Retinal Neurons

(2016) Na Li et al.   NEUROTOXICITY RESEARCH

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

(2016) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis contributes to methamphetamine-induced cytotoxicity in rat cortical neurons

(2016) Kun Xiong et al.   TOXICOLOGY IN VITRO

Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis

(2016) Dominique Bozec et al.   Oncotarget

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

(2015) Wei Ding et al.   BMC NEUROSCIENCE

Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner

(2015) Martín Roffé et al.   CELLULAR SIGNALLING

RSK3: A regulator of pathological cardiac remodeling

(2015) Eliana C. Martinez et al.   IUBMB LIFE

The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning

(2015) Rossana Zaru et al.   JOURNAL OF IMMUNOLOGY

Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning

(2015) Shin-ichi Miyake et al.   JOURNAL OF NEUROCHEMISTRY

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells

(2015) Alastair H. Davies et al.   Oncotarget

The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide

(2014) San-Hong Jiang et al.   BMC Complementary and Alternative Medicine

Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor

(2014) Avril Pereira et al.   BMC NEUROSCIENCE

Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

(2014) Ida Aronchik et al.   MOLECULAR CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice

(2013) Catherine L. Passariello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response

(2013) Ju-Fang Huang et al.   BMC NEUROSCIENCE

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

(2013) Violeta Serra et al.   JOURNAL OF CLINICAL INVESTIGATION

p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes

(2013) Ze Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Inhibition of ERK Activation Mediates the Protection of Necrostatin-1 on Glutamate Toxicity in HT-22 Cells

(2013) Min Zhang et al.   NEUROTOXICITY RESEARCH

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

(2013) S J Kim et al.   Cell Death & Disease

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Anchored p90 Ribosomal S6 Kinase 3 Is Required for Cardiac Myocyte Hypertrophy

(2012) Jinliang Li et al.   CIRCULATION RESEARCH

Regulation and function of the RSK family of protein kinases

(2011) Yves Romeo et al.   BIOCHEMICAL JOURNAL

Differential Changes of Local Blood Supply in Rat Retinae Are Involved in the Selective Loss of Retinal Ganglion Cells Following the Acute High Intraocular Pressure

(2010) Jian-bin Tong et al.   CURRENT EYE RESEARCH

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation

(2009) Rachel L. Yamnik et al.   FEBS LETTERS

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

(2009) Daniel M. Rosenbaum et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells

(2009) Ulrik Doehn et al.   MOLECULAR CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

The RSK factors of activating the Ras/MAPK signaling cascade

(2008) Audrey Carriere   Frontiers in Bioscience-Landmark