Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

CAVER: Algorithms for Analyzing Dynamics of Tunnels in Macromolecules

(2016) Antonin Pavelka et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family

(2016) D. F. Young et al.   JOURNAL OF VIROLOGY

‘Z-DNA like’ fragments in RNA: a recurring structural motif with implications for folding, RNA/protein recognition and immune response

(2016) Luigi D'Ascenzo et al.   NUCLEIC ACIDS RESEARCH

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

(2016) Matthew D Daugherty et al.   eLife

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

(2015) Bo Liang et al.   CELL

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

(2015) Christine Schuberth-Wagner et al.   IMMUNITY

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families

(2015) Amelia K. Pinto et al.   JOURNAL OF VIROLOGY

Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

(2015) Jennifer L. Hyde et al.   VIROLOGY

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

(2015) Josephine M. Reynaud et al.   PLoS Pathogens

No Love Lost Between Viruses and Interferons

(2015) Volker Fensterl et al.   Annual Review of Virology

Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2'-O-Methyltransferase Activity

(2014) V. D. Menachery et al.   JOURNAL OF VIROLOGY

Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

(2014) Volker Fensterl et al.   JOURNAL OF VIROLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

(2014) J. L. Hyde et al.   SCIENCE

Crystal structure and nucleotide selectivity of human IFIT5/ISG58

(2013) Feng Feng et al.   CELL RESEARCH

Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5' Capped 2'-O Unmethylated RNA

(2013) T. Kimura et al.   JOURNAL OF VIROLOGY

tRNA Binding, Structure, and Localization of the Human Interferon-Induced Protein IFIT5

(2013) George E. Katibah et al.   MOLECULAR CELL

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

(2013) P. Kumar et al.   NUCLEIC ACIDS RESEARCH

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

(2013) Roland Züst et al.   PLoS Pathogens

The Cation−π Interaction

(2012) Dennis A. Dougherty   ACCOUNTS OF CHEMICAL RESEARCH

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

(2012) Zhenlin Yang et al.   CELL RESEARCH

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N7)-methyl transferase

(2012) Y. Thillier et al.   RNA

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

(2012) Kristy J. Szretter et al.   PLoS Pathogens

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Beamline 08ID-1, the prime beamline of the Canadian Macromolecular Crystallography Facility

(2011) Pawel Grochulski et al.   JOURNAL OF SYNCHROTRON RADIATION

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

2′-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

(2011) Maria Werner et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Pioneer Round of Translation: Features and Functions

(2010) Lynne E. Maquat et al.   CELL

Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

(2010) François Bélanger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

(2010) Ivan Zlatev et al.   ORGANIC LETTERS

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Translation factors promote the formation of two states of the closed-loop mRNP

(2008) Nadia Amrani et al.   NATURE