Phosphorothioate Modification of mRNA Accelerates the Rate of Translation Initiation to Provide More Efficient Protein Synthesis

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone

(2018) Hannah E. Keedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

(2018) Kyle W. Knouse et al.   SCIENCE

Therapeutic Oligonucleotides: State of the Art

(2018) C.I. Edvard Smith et al.   Annual Review of Pharmacology and Toxicology

The stop and go traffic regulating protein biogenesis: how translation kinetics control proteostasis

(2018) Kevin C. Stein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mRNA-Based Protein Replacement Therapy for the Heart

(2018) Ajit Magadum et al.   MOLECULAR THERAPY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

(2017) Naoki Iwamoto et al.   NATURE BIOTECHNOLOGY

Effects of Chemically Modified Messenger RNA on Protein Expression

(2016) Bin Li et al.   BIOCONJUGATE CHEMISTRY

Molecular insights into protein synthesis with proline residues

(2016) Sergey Melnikov et al.   EMBO REPORTS

Differential Scanning Fluorimetry for Monitoring RNA Stability

(2015) Robert Silvers et al.   CHEMBIOCHEM

Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function

(2015) Cristian Del Campo et al.   PLoS Genetics

Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

(2015) Satoshi Uchida et al.   Pharmaceutics

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′-O-(2-Cyanoethoxymethyl)-nucleoside 3′-O-Oxazaphospholidine Monomers

(2012) Yohei Nukaga et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms

(2011) Natsuhisa Oka et al.   CHEMICAL SOCIETY REVIEWS

Ribosomal Translocation: One Step Closer to the Molecular Mechanism

(2009) Shinichiro Shoji et al.   ACS Chemical Biology

Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

(2009) Natsuhisa Oka et al.   ORGANIC LETTERS