Immunoengineering the next generation of arthritis therapies

OCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo

(2020) Longfa Kou et al.   DRUG DELIVERY

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

(2020) Jiajie Tu et al.   MEDIATORS OF INFLAMMATION

Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

(2020) Reza Mohammadinejad et al.   Current Rheumatology Reports

Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

(2020) Nguyen PT Huynh et al.   eLife

Macrophages of diverse phenotypes drive vascularization of engineered tissues

(2020) P. L. Graney et al.   Science Advances

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis

(2020) Yen-Ju Lin et al.   Cells

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Shattering barriers toward clinically meaningful MSC therapies

(2020) Oren Levy et al.   Science Advances

Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications

(2020) Mercedes Lopez-Santalla et al.   Cells

Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models

(2020) Yuchen He et al.   Biology-Basel

In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells

(2020) Bo Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting interleukin-4 to the arthritic joint

(2020) Valerie Spieler et al.   JOURNAL OF CONTROLLED RELEASE

Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

(2020) Isabel Matos Oliveira et al.   Biomolecules

Harnessing Macrophages for Controlled-Release Drug Delivery: Lessons From Microbes

(2019) Johan Georg Visser et al.   Frontiers in Pharmacology

High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis

(2019) Rachel Yamin et al.   Scientific Reports

Study of the adoptive immunotherapy on rheumatoid arthritis with Thymus-derived invariant natural killer T cells

(2019) Dongzhi Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

(2019) Jinwei Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity

(2019) Jay M. Patel et al.   Acta Biomaterialia

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

MSC Therapy for Osteoarthritis: An Unfinished Story

(2019) Frank Barry   JOURNAL OF ORTHOPAEDIC RESEARCH

Secretory factors produced by adipose mesenchymal stem cells downregulate Th17 and increase Treg cells in peripheral blood mononuclear cells from rheumatoid arthritis patients

(2019) Georgi Vasilev et al.   RHEUMATOLOGY INTERNATIONAL

A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues

(2019) Lara Pferdehirt et al.   TISSUE ENGINEERING PART A

The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis

(2019) Yuangang Wu et al.   CURRENT GENE THERAPY

The Interaction between Joint Inflammation and Cartilage Repair

(2019) Peter M. van der Kraan   Tissue Engineering and Regenerative Medicine

Applications of RNA interference in the treatment of arthritis

(2019) Muhammad Farooq Rai et al.   Translational Research

Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis

(2019) Jiajie Tu et al.   Frontiers in Immunology

Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis

(2019) Derek T Holyoak et al.   Regenerative Biomaterials

Role of Inflammation and the Immune System in the Progression of Osteoarthritis

(2019) Jennifer E. Woodell‐May et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

(2019) Elizabeth C. Wayne et al.   Advanced Science

Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

(2019) Guorong Hu et al.   Frontiers in Immunology

Role of macrophage TRPV4 in inflammation

(2019) Bidisha Dutta et al.   LABORATORY INVESTIGATION

Parallel comparison of fibroblast-like synoviocytes from the surgically removed hyperplastic synovial tissues of rheumatoid arthritis and osteoarthritis patients

(2019) Wei Huang et al.   BMC MUSCULOSKELETAL DISORDERS

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells

(2018) S. Alivernini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Anakinra for the treatment of rheumatoid arthritis: a safety evaluation

(2018) Julio Ramírez et al.   Expert Opinion On Drug Safety

Gene Delivery to Joints by Intra-Articular Injection

(2018) Christopher H. Evans et al.   HUMAN GENE THERAPY

CRISPR and personalized Treg therapy: new insights into the treatment of rheumatoid arthritis

(2018) Fatemeh Safari et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system

(2018) Shaowei Wang et al.   International Journal of Nanomedicine

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain

(2018) Philip G. Conaghan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment

(2018) Simone Gabner et al.   JOURNAL OF GENE MEDICINE

Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review

(2018) K. Nakata et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis

(2018) Liane E. Tellier et al.   Biomaterials Science

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

Health Care Provider Counseling for Physical Activity or Exercise Among Adults with Arthritis — United States, 2002 and 2014

(2018) Jennifer M. Hootman et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Human Placenta-Derived Mesenchymal Stem Cells with Silk Fibroin Biomaterial in the Repair of Articular Cartilage Defects

(2018) Fang Li et al.   Cellular Reprogramming

Clinical and radiographic outcomes of chitosan-glycerol phosphate/blood implant are similar with hyaluronic acid-based cell-free scaffold in the treatment of focal osteochondral lesions of the knee joint

(2018) Hakan Sofu et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention

(2018) Min Li et al.   Nano Research

Collagen Scaffolds in Cartilage Tissue Engineering and Relevant Approaches for Future Development

(2018) Vincent Irawan et al.   Tissue Engineering and Regenerative Medicine

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease

(2018) Matthew J. Johnson et al.   Scientific Reports

T Cells That Help B Cells in Chronically Inflamed Tissues

(2018) Deepak A. Rao   Frontiers in Immunology

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting the extracellular matrix for delivery of bioactive molecules to sites of arthritis

(2018) Christopher Schultz   BRITISH JOURNAL OF PHARMACOLOGY

Spatial confinement downsizes the inflammatory response of macrophages

(2018) Nikhil Jain et al.   NATURE MATERIALS

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

(2017) Jinlong Zhao et al.   International Journal of Nanomedicine

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

(2017) C.-Y. Yang et al.   OSTEOARTHRITIS AND CARTILAGE

CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?

(2017) Dario Gerace et al.   Stem Cell Research & Therapy

Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue

(2017) Francesca Taraballi et al.   Stem Cells Translational Medicine

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues

(2017) Jonathan M. Brunger et al.   Arthritis & Rheumatology

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs

(2017) Jonathan M. Brunger et al.   Stem Cell Reports

Effectiveness of intra-articular therapies in osteoarthritis: a literature review

(2017) Peter Wehling et al.   Therapeutic Advances in Musculoskeletal Disease

Etanercept-Synthesising Mesenchymal Stem Cells Efficiently Ameliorate Collagen-Induced Arthritis

(2017) Narae Park et al.   Scientific Reports

Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis

(2016) Mi-Lan Kang et al.   Acta Biomaterialia

IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease

(2016) Ushani Srenathan et al.   IMMUNOLOGY LETTERS

Non–TNF-Targeted Biologic vs a Second Anti-TNF Drug to Treat Rheumatoid Arthritis in Patients With Insufficient Response to a First Anti-TNF Drug

(2016) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

(2016) Mario Moisés Alvarez et al.   JOURNAL OF CONTROLLED RELEASE

Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells

(2016) Simone Gabner et al.   JOURNAL OF GENE MEDICINE

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

(2016) Van Trung Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

The Role of MicroRNAs and Their Targets in Osteoarthritis

(2016) Gregory R. Sondag et al.   Current Rheumatology Reports

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

(2016) Mohammad Haque et al.   Jove-Journal of Visualized Experiments

Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

(2015) Shardool Jain et al.   BIOMATERIALS

Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses

(2015) Audrey Petit et al.   BIOMATERIALS

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapy

(2015) Debbie M. Roeleveld et al.   CYTOKINE

Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance

(2015) Pu-Ste Liu et al.   Adipocyte

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

(2015) Caroline J. Aalbers et al.   PLoS One

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

(2014) Katherine A. Glass et al.   BIOMATERIALS

Osteoarthritis joint pain: The cytokine connection

(2014) Rachel E. Miller et al.   CYTOKINE

In vitro evaluation of effects of sustained anti-TNF release from MPEG-PCL-MPEG and PCL microspheres on human rheumatoid arthritis synoviocytes

(2014) Özge Erdemli et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

(2014) Hui-fang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

(2014) Bridgette D Furman et al.   ARTHRITIS RESEARCH & THERAPY

Use of Cartilage Derived From Murine Induced Pluripotent Stem Cells for Osteoarthritis Drug Screening

(2014) Vincent P. Willard et al.   Arthritis & Rheumatology

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Immunopathogenesis of osteoarthritis

(2013) Abdul Haseeb et al.   CLINICAL IMMUNOLOGY

Mesenchymal Stem Cell Survival in the Infarcted Heart Is Enhanced by Lentivirus Vector-Mediated Heat Shock Protein 27 Expression

(2013) Lisa M. McGinley et al.   HUMAN GENE THERAPY

The problem of choice: current biologic agents and future prospects in RA

(2013) Ernest H. Choy et al.   Nature Reviews Rheumatology

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

(2013) Guangyi Li et al.   ARTHRITIS RESEARCH & THERAPY

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

Programming of Regulatory T Cells from Pluripotent Stem Cells and Prevention of Autoimmunity

(2012) R. Haque et al.   JOURNAL OF IMMUNOLOGY

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells

(2012) B. O. Diekman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Stem Cells Home to Sites of Injury and Inflammation

(2012) Kristine C. Rustad et al.   Advances in Wound Care

Emerging drugs for osteoarthritis

(2011) Gloria L Matthews et al.   EXPERT OPINION ON EMERGING DRUGS

Scaffold-Guided Subchondral Bone Repair

(2010) Caroline D. Hoemann et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis

(2010) G. Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Innate Immunity and Rheumatoid Arthritis

(2010) Angelica Gierut et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

The role of synovitis in osteoarthritis

(2010) Claire Y. J. Wenham et al.   Therapeutic Advances in Musculoskeletal Disease

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Intra-articular drug delivery systems: overcoming the shortcomings of joint disease therapy

(2009) Helen M Burt et al.   Expert Opinion on Drug Delivery

Clinical Responses to Gene Therapy in Joints of Two Subjects with Rheumatoid Arthritis

(2009) Peter Wehling et al.   HUMAN GENE THERAPY

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Stem Cell Review Series: Aging of the skeletal muscle stem cell niche

(2008) Suchitra D. Gopinath et al.   AGING CELL

The development of novel therapies for rheumatoid arthritis

(2008) Ling-dong Quan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Regenerative pharmacology in the treatment of genetic diseases: The paradigm of muscular dystrophy

(2008) Chiara Mozzetta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY