CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues

Genome-editing Technologies for Gene and Cell Therapy

(2016) Morgan L Maeder et al.   MOLECULAR THERAPY

Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing

(2016) Franklin T. Moutos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients Through Genomic Excision of Exon 51 by Zinc Finger Nucleases

(2015) David G Ousterout et al.   MOLECULAR THERAPY

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

(2015) Pratiksha I Thakore et al.   NATURE METHODS

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

(2015) Lina Schukur et al.   Science Translational Medicine

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

(2014) Katherine A. Glass et al.   BIOMATERIALS

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

(2014) Keiichiro Suzuki et al.   Cell Stem Cell

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

(2014) Akihiro Yamashita et al.   NATURE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

(2014) Bridgette D Furman et al.   ARTHRITIS RESEARCH & THERAPY

Use of Cartilage Derived From Murine Induced Pluripotent Stem Cells for Osteoarthritis Drug Screening

(2014) Vincent P. Willard et al.   Arthritis & Rheumatology

The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells

(2013) Dominick J. Blasioli et al.   BIOMATERIALS

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application

(2013) Gaoyang Liang et al.   Cell Stem Cell

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

(2013) Amy L. McNulty et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

Disease Modification

(2013) Gloria L. Matthews   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Growth factor transgenes interactively regulate articular chondrocytes

(2012) Shuiliang Shi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells

(2012) B. O. Diekman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Engineering Complex Tissues

(2012) A. Atala et al.   Science Translational Medicine

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

The Effects of Adipokines on Cartilage and Meniscus Catabolism

(2011) Amy L. McNulty et al.   CONNECTIVE TISSUE RESEARCH

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

(2011) Miguel Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Readily Available Tissue-Engineered Vascular Grafts

(2011) S. L. M. Dahl et al.   Science Translational Medicine

Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells

(2011) Genoveva T.H. Heldens et al.   TISSUE ENGINEERING PART A

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

(2009) N. Wehling et al.   ARTHRITIS AND RHEUMATISM

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

(2009) Krishanu Saha et al.   Cell Stem Cell

Autoimmune diseases induced by TNF-targeted therapies

(2008) Manuel Ramos-Casals et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Differences in Interleukin-1 Response Between Engineered and Native Cartilage

(2008) Eric G. Lima et al.   TISSUE ENGINEERING PART A

ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

(2007) Haibing Peng et al.   JOURNAL OF CELLULAR PHYSIOLOGY