3-Hydroxybutyrate as a Metabolite and a Signal Molecule Regulating Processes of Living Organisms

Why a d-β-hydroxybutyrate monoester?

(2020) Adrian Soto-Mota et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effects of a ketogenic diet in overweight women with polycystic ovary syndrome

(2020) Antonio Paoli et al.   Journal of Translational Medicine

Lipid Catabolism in Starved Yak Is Inhibited by Intravenous Infusion of β-Hydroxybutyrate

(2020) Huawei Zou et al.   Animals

β-hydroxybutyrate and its metabolic effects on age-associated pathology

(2020) Young-Min Han et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

3-Hydroxybutyrate Is Active Compound in Flax that Upregulates Genes Involved in DNA Methylation

(2020) Justyna Mierziak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

(2020) Arkadiusz Dąbek et al.   Nutrients

A ketogenic diet elicits anti-tumor properties through inducing oxidative stress, inhibiting MMP-9 expression and rebalancing M1/M2 tumor-associated macrophages phenotype in a mouse model of colon cancer

(2020) Ning Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters

(2020) Souad Nasser et al.   World Journal of Diabetes

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

Bone loss and biomechanical reduction of appendicular and axial bones under ketogenic diet in rats

(2019) Jianyang Ding et al.   Experimental and Therapeutic Medicine

The effects of non-esterified fatty acids and β-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis

(2019) Zhicheng Peng et al.   JOURNAL OF DAIRY RESEARCH

Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial

(2019) Yi Wan et al.   GUT

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance

(2019) A. Benedet et al.   Animal

Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention

(2019) Elena C. Gross et al.   Nutrients

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

(2019) Peng Li et al.   MOLECULES

Ketogenic diet in the treatment of cancer – Where do we stand?

(2019) Daniela D. Weber et al.   Molecular Metabolism

Diabetic Ketoacidosis

(2019) Katherine Cashen et al.   PEDIATRICS IN REVIEW

Ketone bodies, stress response, and redox homeostasis

(2019) Pedro Rojas-Morales et al.   Redox Biology

The ketogenic diet: Pros and cons

(2019) Blair O'Neill et al.   ATHEROSCLEROSIS

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease

(2019) Yancheng Wu et al.   FASEB JOURNAL

Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy

(2019) Siqi Feng et al.   PHARMACOLOGICAL RESEARCH

β-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet

(2018) J.N. Wright et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Effect of maternal metabolism on fetal supply: Glucose, non-esterified fatty acids and beta-hydroxybutyrate concentrations in canine maternal serum and fetal fluids at term pregnancy

(2018) Orsolya Balogh et al.   ANIMAL REPRODUCTION SCIENCE

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study

(2018) Nasir H. Bhanpuri et al.   Cardiovascular Diabetology

Polyhydroxyalkanoates (PHA) for therapeutic applications

(2018) Junyu Zhang et al.   Materials Science & Engineering C-Materials for Biological Applications

Beta-hydroxybutyrate infusion identifies acutely differentially expressed genes related to metabolism and reproduction in the hypothalamus and pituitary of castrated male sheep

(2018) Emily R. Cope et al.   PHYSIOLOGICAL GENOMICS

The association of serum β-hydroxybutyrate concentration with fetal number and health indicators in late-gestation ewes in commercial meat flocks in Prince Edward Island

(2018) Niorn Ratanapob et al.   PREVENTIVE VETERINARY MEDICINE

Microbial functional diversity plays an important role in the degradation of polyhydroxybutyrate (PHB) in soil

(2018) Samrat Dey et al.   3 Biotech

Microbial functional diversity plays an important role in the degradation of polyhydroxybutyrate (PHB) in soil

(2018) Samrat Dey et al.   3 Biotech

The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome

(2018) Sen Shang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Metabolic gene expression and epigenetic effects of the ketone body β-hydroxybutyrate on H3K9ac in bovine cells, oocytes and embryos

(2018) Juliano Rodrigues Sangalli et al.   Scientific Reports

Poly(3-hydroxybutyrate) and Human Microbiota (Review)

(2018) A. P. Bonartsev et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

(2018) Saroj Chakraborty et al.   Cell Reports

The effect of the ketogenic diet on the developing skeleton

(2017) Peter J. Simm et al.   EPILEPSY RESEARCH

Biosynthesis of enantiopure ( S )-3-hydroxybutyrate from glucose through the inverted fatty acid β-oxidation pathway by metabolically engineered Escherichia coli

(2017) Andrey Yu. Gulevich et al.   JOURNAL OF BIOTECHNOLOGY

Management of Hyperglycemic Crises

(2017) Maya Fayfman et al.   MEDICAL CLINICS OF NORTH AMERICA

The diabetic heart utilizes ketone bodies as an energy source

(2017) Yuji Mizuno et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

(2017) Takehiko Yamanashi et al.   Scientific Reports

Microbial polyhydroxyalkanoates as medical implant biomaterials

(2017) Guo-Qiang Chen et al.   Artificial Cells Nanomedicine and Biotechnology

Association Between Circulating Ketone Bodies and Worse Outcomes in Hemodialysis Patients

(2017) Masaru Obokata et al.   Journal of the American Heart Association

Expression of the entire polyhydroxybutyrate operon of Ralstonia eutropha in plants

(2017) Rita Mozes-Koch et al.   Journal of Biological Engineering

Production of (R)-3-hydroxybutyric acid by Arxula adeninivorans

(2017) Mateusz Biernacki et al.   AMB Express

β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway

(2016) Yuxiang Song et al.   JOURNAL OF DAIRY SCIENCE

Generation of poly-β-hydroxybutyrate from acetate in higher plants: Detection of acetoacetyl CoA reductase- and PHB synthase- activities in rice

(2016) Hirohisa Tsuda et al.   JOURNAL OF PLANT PHYSIOLOGY

Serum Beta Hydroxybutyrate Concentrations in Cats with Chronic Kidney Disease, Hyperthyroidism, or Hepatic Lipidosis

(2016) L. Gorman et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2

(2016) Emily C. Graff et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Methyl-esterified 3-hydroxybutyrate oligomers protect bacteria from hydroxyl radicals

(2016) Janne J Koskimäki et al.   Nature Chemical Biology

Ketones block amyloid entry and improve cognition in an Alzheimer's model

(2016) Jun Xiang Yin et al.   NEUROBIOLOGY OF AGING

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

(2016) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation

(2016) Ha Ram Bae et al.   Oncotarget

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

(2015) Nicholas Douris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy

(2015) Jeong A Kim et al.   EPILEPSIA

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

(2015) Shou-Peng Fu et al.   Journal of Neuroinflammation

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

(2014) Johanne H. Ellenbroek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Factors affecting polyhydroxybutyrate accumulation in mesophyll cells of sugarcane and switchgrass

(2014) Richard B McQualter et al.   BMC BIOTECHNOLOGY

Polyhydroxyalkanoates, challenges and opportunities

(2014) Ying Wang et al.   CURRENT OPINION IN BIOTECHNOLOGY

β-hydroxybutyrate: Much more than a metabolite

(2014) John C. Newman et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

(2014) A.M. Poff et al.   INTERNATIONAL JOURNAL OF CANCER

A field study to determine the prevalence, dairy herd management systems, and fresh cow clinical conditions associated with ketosis in western European dairy herds

(2014) Anna C. Berge et al.   JOURNAL OF DAIRY SCIENCE

Diseases, reproductive performance, and changes in milk production associated with subclinical ketosis in dairy cows: A meta-analysis and review

(2014) D. Raboisson et al.   JOURNAL OF DAIRY SCIENCE

BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-κB Activation

(2014) Shou-Peng Fu et al.   MEDIATORS OF INFLAMMATION

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

(2014) Elena N. Dedkova et al.   Frontiers in Physiology

Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows

(2013) V.S. Suthar et al.   JOURNAL OF DAIRY SCIENCE

PHA Bioplastics, Biochemicals, and Energy from Crops

(2013) Maria N. Somleva et al.   PLANT BIOTECHNOLOGY JOURNAL

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

(2013) Angela M. Poff et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance

(2013) Jessica A.A. McArt et al.   VETERINARY JOURNAL

PHB granules are attached to the nucleoid via PhaM in Ralstonia eutropha

(2012) Andreas Wahl et al.   BMC MICROBIOLOGY

HDAC inhibitor-based therapies: Can we interpret the code?

(2012) Maria New et al.   Molecular Oncology

Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development

(2012) Huanan Jin et al.   PLANT JOURNAL

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Effects of β-hydroxybutyrate and isoproterenol on lipolysis in isolated adipocytes from periparturient dairy cows and cows with clinical ketosis

(2012) S.G.A. van der Drift et al.   RESEARCH IN VETERINARY SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

(2011) Cameron J Holloway et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

(2011) S. Offermanns et al.   PHARMACOLOGICAL REVIEWS

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease

(2011) David N. Ruskin et al.   PHYSIOLOGY & BEHAVIOR

High Levels of Bioplastic Are Produced in Fertile Transplastomic Tobacco Plants Engineered with a Synthetic Operon for the Production of Polyhydroxybutyrate

(2011) K. Bohmert-Tatarev et al.   PLANT PHYSIOLOGY

Generation of poly-β-hydroxybutyrate from externally provided acetate in rice root

(2011) Hirohisa Tsuda   PLANT PHYSIOLOGY AND BIOCHEMISTRY

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease

(2011) Soyeon Lim et al.   PLoS One

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Bacterial polymers: biosynthesis, modifications and applications

(2010) Bernd H. A. Rehm   NATURE REVIEWS MICROBIOLOGY

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Antiepileptic drug therapy the story so far

(2010) Martin J. Brodie   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Renal Stone Associated with the Ketogenic Diet in a 5-Year Old Girl with Intractable Epilepsy

(2010) Ji Na Choi et al.   YONSEI MEDICAL JOURNAL

Bacterial Polyhydroxyalkanoate Granules: Biogenesis, Structure, and Potential Use as Nano-/Micro-Beads in Biotechnological and Biomedical Applications

(2009) Katrin Grage et al.   BIOMACROMOLECULES

A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry

(2009) Guo-Qiang Chen   CHEMICAL SOCIETY REVIEWS

The ketogenic diet and epilepsy

(2009) Do Young Kim et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Ketone bodies inhibit the viability of human neuroblastoma cells

(2009) Robert Skinner et al.   JOURNAL OF PEDIATRIC SURGERY

Functional Characterization of the Arabidopsis  -Ketoacyl-Coenzyme A Reductase Candidates of the Fatty Acid Elongase

(2009) F. Beaudoin et al.   PLANT PHYSIOLOGY

Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine

(2009) Renske van Delft et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides

(2008) Christoph Otto et al.   BMC CANCER

Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions

(2008) María L. Haces et al.   EXPERIMENTAL NEUROLOGY

Binding of the Major Phasin, PhaP1, from Ralstonia eutropha H16 to Poly(3-Hydroxybutyrate) Granules

(2008) L. Neumann et al.   JOURNAL OF BACTERIOLOGY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Production of polyhydroxybutyrate in switchgrass, a value-added co-product in an important lignocellulosic biomass crop

(2008) Maria N. Somleva et al.   PLANT BIOTECHNOLOGY JOURNAL

Liver-Specific Silencing of the Human Gene Encoding Succinyl-CoA: 3-Ketoacid CoA Transferase

(2008) Kenji E. Orii et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE