标题
HDAC inhibitor-based therapies: Can we interpret the code?
作者
关键词
-
出版物
Molecular Oncology
Volume 6, Issue 6, Pages 637-656
出版商
Wiley
发表日期
2012-10-23
DOI
10.1016/j.molonc.2012.09.003
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors
- (2012) William Guerrant et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sirtuins mediate mammalian metabolic responses to nutrient availability
- (2012) Angeliki Chalkiadaki et al. Nature Reviews Endocrinology
- Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development
- (2012) Sébastien Moniot et al. Frontiers in Pharmacology
- HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma
- (2011) D. Buglio et al. BLOOD
- HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL
- (2011) M. Kalac et al. BLOOD
- Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
- (2011) R. L. Piekarz et al. BLOOD
- Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours
- (2011) R Pili et al. BRITISH JOURNAL OF CANCER
- Effect of valproic acid on the outcome of glioblastoma multiforme
- (2011) Hong-Chieh Tsai et al. BRITISH JOURNAL OF NEUROSURGERY
- Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: Efficacy and underlying mechanisms
- (2011) Sabine Mueller et al. CANCER LETTERS
- HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance
- (2011) Xiaoping Huang et al. CANCER LETTERS
- Mutant p53 protein localized in the cytoplasm inhibits autophagy
- (2011) Eugenia Morselli et al. CELL CYCLE
- HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo
- (2011) T. Nguyen et al. CLINICAL CANCER RESEARCH
- Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent
- (2011) Jane L. Hurwitz et al. EUROPEAN JOURNAL OF CANCER
- Preclinical and clinical activity of the topoisomerase I inhibitor, karenitecin, in melanoma
- (2011) Pamela N Munster et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor
- (2011) Yanis Boumber et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
- (2011) Omar Khan et al. IMMUNOLOGY AND CELL BIOLOGY
- Histone Deacetylases 9 and 10 Are Required for Homologous Recombination
- (2011) Shweta Kotian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
- (2011) Stamatios Theocharis et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Suppression of Histone Deacetylase 11 Promotes Expression of IL-10 in Kupffer Cells and Induces Tolerance Following Orthotopic Liver Transplantation in Rats
- (2011) Zheng-rong Lian et al. JOURNAL OF SURGICAL RESEARCH
- Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor
- (2011) Wenjuan Yu et al. LEUKEMIA RESEARCH
- Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
- (2011) Yoshihiro Minamiya et al. LUNG CANCER
- Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
- (2011) G. Dasmahapatra et al. MOLECULAR CANCER THERAPEUTICS
- DNA damage and autophagy
- (2011) Humberto Rodriguez-Rocha et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
- (2011) Marcus Bantscheff et al. NATURE BIOTECHNOLOGY
- Autophagy as a target for anticancer therapy
- (2011) Filip Janku et al. Nature Reviews Clinical Oncology
- Predictive biomarkers: a paradigm shift towards personalized cancer medicine
- (2011) Nicholas B. La Thangue et al. Nature Reviews Clinical Oncology
- A Pilot Phase II Study of Valproic Acid for Treatment of Low-Grade Neuroendocrine Carcinoma
- (2011) T. A. Mohammed et al. ONCOLOGIST
- Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells
- (2011) Luca A. Petruccelli et al. PLoS One
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection
- (2010) T. Roger et al. BLOOD
- Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma
- (2010) Ruben Niesvizky et al. CANCER
- Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells
- (2010) Feng Zhang et al. CANCER BIOLOGY & THERAPY
- Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21waf1/cip1 expression
- (2010) Rintaro Noro et al. CANCER SCIENCE
- Valproic Acid in the Complex Therapy of Malignant Tumors
- (2010) J. Hrebackova et al. CURRENT DRUG TARGETS
- Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis
- (2010) Roel H Wilting et al. EMBO JOURNAL
- HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
- (2010) Joo-Yong Lee et al. EMBO JOURNAL
- The clinical development of histone deacetylase inhibitors as targeted anticancer drugs
- (2010) Paul A Marks EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression
- (2010) T. Yamaguchi et al. GENES & DEVELOPMENT
- Enhancement of Radiation Response in Osteosarcoma and Rhabomyosarcoma Cell Lines by Histone Deacetylase Inhibition
- (2010) Claudia Blattmann et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Regulation of MyD88 Aggregation and the MyD88-dependent Signaling Pathway by Sequestosome 1 and Histone Deacetylase 6
- (2010) Takeshi Into et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT
- (2010) Francesca Bruzzese et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS
- (2010) Maria A. Halili et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Network organization of the human autophagy system
- (2010) Christian Behrends et al. NATURE
- Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
- (2010) Kyle M Miller et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inhibition of Radiation-Induced DNA Repair and Prosurvival Pathways Contributes to Vorinostat-Mediated Radiosensitization of Pancreatic Cancer Cells
- (2010) Amit Deorukhkar et al. PANCREAS
- Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is Mediated through the E2F1 Transcription Factor
- (2010) Sushant K. Kachhap et al. PLoS One
- Identification of Histone Deacetylase 3 as a Biomarker for Tumor Recurrence Following Liver Transplantation in HBV-Associated Hepatocellular Carcinoma
- (2010) Li-Ming Wu et al. PLoS One
- HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy
- (2010) O. Khan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)
- (2009) L. R. Molife et al. ANNALS OF ONCOLOGY
- HDAC inhibitor-based therapies and haematological malignancy
- (2009) L. Stimson et al. ANNALS OF ONCOLOGY
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells
- (2009) C. Urbich et al. BLOOD
- Genome-wide Loss-of-Function Screen Reveals an Important Role for the Proteasome in HDAC Inhibitor-Induced Apoptosis
- (2009) Susan Fotheringham et al. CANCER CELL
- Biomarkers for predicting clinical responses to HDAC inhibitors
- (2009) Lindsay Stimson et al. CANCER LETTERS
- Development of vorinostat: Current applications and future perspectives for cancer therapy
- (2009) Victoria M. Richon et al. CANCER LETTERS
- c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells
- (2009) S. Lorin et al. CANCER RESEARCH
- Atg5 Regulates Phenethyl Isothiocyanate-Induced Autophagic and Apoptotic Cell Death in Human Prostate Cancer Cells
- (2009) A. Bommareddy et al. CANCER RESEARCH
- The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
- (2009) T. Liu et al. CANCER RESEARCH
- Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
- (2009) E. Bolderson et al. CLINICAL CANCER RESEARCH
- Phase I Study of Vorinostat in Combination with Bortezomib for Relapsed and Refractory Multiple Myeloma
- (2009) A. Badros et al. CLINICAL CANCER RESEARCH
- PCI-24781 Induces Caspase and Reactive Oxygen Species-Dependent Apoptosis Through NF- B Mechanisms and Is Synergistic with Bortezomib in Lymphoma Cells
- (2009) S. Bhalla et al. CLINICAL CANCER RESEARCH
- Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells
- (2009) T.-L. Cha et al. CLINICAL CANCER RESEARCH
- The Double-Edged Sword of Autophagy Modulation in Cancer
- (2009) E. White et al. CLINICAL CANCER RESEARCH
- Targeting of HDAC8 and investigational inhibitors in neuroblastoma
- (2009) Ina Oehme et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A phosphorylation-acetylation switch regulates STAT1 signaling
- (2009) O. H. Kramer et al. GENES & DEVELOPMENT
- A Systematic Assessment of Radiation Dose Enhancement by 5-Aza-2′-Deoxycytidine and Histone Deacetylase Inhibitors in Head-and-Neck Squamous Cell Carcinoma
- (2009) Harlinde De Schutter et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- HDAC4 Represses Vascular Endothelial Growth Factor Expression in Chondrosarcoma by Modulating RUNX2 Activity
- (2009) Xiaojuan Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation
- (2009) Jennifer S. Carew et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Carboplatin and Paclitaxel in Combination With Either Vorinostat or Placebo for First-Line Therapy of Advanced Non–Small-Cell Lung Cancer
- (2009) Suresh S. Ramalingam et al. JOURNAL OF CLINICAL ONCOLOGY
- HDAC2 regulates chromatin plasticity and enhances DNA vulnerability
- (2009) D. C. Marchion et al. MOLECULAR CANCER THERAPEUTICS
- Is There a Future for Histone Deacetylase Inhibitors in the Pharmacotherapy of Psychiatric Disorders?
- (2009) D. R. Grayson et al. MOLECULAR PHARMACOLOGY
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
- (2009) Feng Ye et al. NATURE NEUROSCIENCE
- Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation
- (2009) E Borbone et al. ONCOGENE
- Expression of Hypoxia-Inducible Factor-1α, Histone Deacetylase 1, and Metastasis-Associated Protein 1 in Pancreatic Carcinoma
- (2009) Kotaro Miyake et al. PANCREAS
- Genetic dissection of histone deacetylase requirement in tumor cells
- (2009) M. Haberland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
- (2009) S. D. Westerheide et al. SCIENCE
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- Oxidative Stress Induces Parallel Autophagy and Mitochondria Dysfunction in Human Glioma U251 Cells
- (2009) Hongyu Zhang et al. TOXICOLOGICAL SCIENCES
- Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors
- (2008) Jung-Hyun Park et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
- (2008) R. Rao et al. BLOOD
- Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
- (2008) L Nolan et al. BRITISH JOURNAL OF CANCER
- Histone deacetylase inhibitors and genomic instability
- (2008) Grégory Eot-Houllier et al. CANCER LETTERS
- HDAC family: What are the cancer relevant targets?
- (2008) Olaf Witt et al. CANCER LETTERS
- The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis
- (2008) Y.-S. Lee et al. CANCER RESEARCH
- Sp1-Mediated TRAIL Induction in Chemosensitization
- (2008) J. Xu et al. CANCER RESEARCH
- Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
- (2008) V. R. Fantin et al. CANCER RESEARCH
- A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors
- (2008) N. L. Steele et al. CLINICAL CANCER RESEARCH
- Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors
- (2008) J. S. de Bono et al. CLINICAL CANCER RESEARCH
- Tolerability, Pharmacodynamics, and Pharmacokinetics Studies of Depsipeptide (Romidepsin) in Patients with Acute Myelogenous Leukemia or Advanced Myelodysplastic Syndromes
- (2008) V. M. Klimek et al. CLINICAL CANCER RESEARCH
- Modulation of TRAIL-Induced Apoptosis by HDAC Inhibitors
- (2008) Simone Fulda CURRENT CANCER DRUG TARGETS
- Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma
- (2008) L Marquard et al. HISTOPATHOLOGY
- Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336)
- (2008) Robert P. Whitehead et al. INVESTIGATIONAL NEW DRUGS
- HDAC6 Is Required for Epidermal Growth Factor-induced β-Catenin Nuclear Localization
- (2008) Yu Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells
- (2008) Xiaocen Kong et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway
- (2008) A Hrzenjak et al. JOURNAL OF PATHOLOGY
- Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma
- (2008) Paul Richardson et al. LEUKEMIA & LYMPHOMA
- Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally
- (2008) Y. Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
- HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21
- (2008) Andrew J. Wilson et al. MOLECULAR BIOLOGY OF THE CELL
- MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
- (2008) M. Fournel et al. MOLECULAR CANCER THERAPEUTICS
- Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control
- (2008) Srividya Bhaskara et al. MOLECULAR CELL
- The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
- (2008) Xiang-Jiao Yang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
- (2008) D Mottet et al. ONCOGENE
- Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
- (2008) A. J. Frew et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
- Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas
- (2008) Omar Khan et al. Nature clinical practice. Oncology
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