An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases
出版年份 2021 全文链接
标题
An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases
作者
关键词
-
出版物
Frontiers in Chemistry
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-03-12
DOI
10.3389/fchem.2021.622286
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Evaluation of potential drugs against leishmaniasis targeting catalytic subunit of Leishmania donovani nuclear DNA primase using ligand based virtual screening, docking and molecular dynamics approaches
- (2020) Deep Bhowmik et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis – A Kinetic Modeling Approach
- (2020) Nikita Bora et al. Frontiers in Genetics
- Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
- (2020) Advait Nagle et al. JOURNAL OF MEDICINAL CHEMISTRY
- In silico identification and evaluation of new Trypanosoma cruzi trypanothione reductase (TcTR) inhibitors obtained from natural products database of the Bahia semi-arid region (NatProDB)
- (2019) Vinícius Guimarães da Paixão et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
- (2019) Susan Wyllie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oral pentamidine-loaded poly(d,l-lactic-co-glycolic) acid nanoparticles: an alternative approach for leishmaniasis treatment
- (2019) Isabela Viol Valle et al. NANOTECHNOLOGY
- Mitochondrial proteome profiling of Leishmania tropica
- (2019) Minoo Tasbihi et al. MICROBIAL PATHOGENESIS
- Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis
- (2019) Mahmoud Reza Jaafari et al. International Journal for Parasitology-Drugs and Drug Resistance
- Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents
- (2019) Wagdy M. Eldehna et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
- (2019) Chiara Borsari et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome ® and AmBisome ® in murine cutaneous leishmaniasis
- (2018) Gert-Jan Wijnant et al. International Journal for Parasitology-Drugs and Drug Resistance
- Itraconazole encapsulated PLGA-nanoparticles covered with mannose as potential candidates against leishmaniasis
- (2018) Lubhandwa Sebastian Biswaro et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
- Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform
- (2018) Jennifer L. Norcliffe et al. Scientific Reports
- Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase
- (2017) D.G. Arias et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis
- (2017) Rafael da Rosa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production
- (2017) Natália P. Nogueira et al. FREE RADICAL BIOLOGY AND MEDICINE
- Assessment of quality of life in patients with post kalaazar dermal leishmaniasis
- (2017) Biplab Pal et al. Health and Quality of Life Outcomes
- Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis
- (2017) Muzamil Y. Want et al. International Journal of Nanomedicine
- Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs
- (2017) Karina Vázquez et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
- (2017) Flavio Di Pisa et al. MOLECULES
- Opportunities and challenges in phenotypic drug discovery: an industry perspective
- (2017) John G. Moffat et al. NATURE REVIEWS DRUG DISCOVERY
- Leishmaniasis in humans: drug or vaccine therapy?
- (2017) Masoud Ghorbani et al. Drug Design Development and Therapy
- Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine
- (2017) Janny A. Villa-Pulgarín et al. PLoS Neglected Tropical Diseases
- Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy
- (2017) Khalid J.H. Alzahrani et al. International Journal for Parasitology-Drugs and Drug Resistance
- Chagas disease research and development: Is there light at the end of the tunnel?
- (2017) Eric Chatelain Computational and Structural Biotechnology Journal
- Efficacy of azole therapy for tegumentary leishmaniasis: A systematic review and meta-analysis
- (2017) Endi Lanza Galvão et al. PLoS One
- Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies
- (2016) María L. Scalise et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Targeting the Cytochromebc1Complex of Leishmania Parasites for Discovery of Novel Drugs
- (2016) Diana Ortiz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity
- (2016) Emilie Durieu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis
- (2016) Brajendra Tiwari et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused byLeishmania braziliensis: A Randomized Controlled Trial
- (2016) Fernanda V. de O. Prates et al. CLINICAL INFECTIOUS DISEASES
- In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives
- (2016) Elsa Moreno-Viguri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
- (2016) Marisa Liliana Fernández et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
- (2016) Shilpi Khare et al. NATURE
- Proteasome inhibition combats kinetoplastid infections
- (2016) Sarah Crunkhorn NATURE REVIEWS DRUG DISCOVERY
- Allopurinol Resistance in Leishmania infantum from Dogs with Disease Relapse
- (2016) Daniel Yasur-Landau et al. PLoS Neglected Tropical Diseases
- Psychological and Psychosocial Consequences of Zoonotic Cutaneous Leishmaniasis among Women in Tunisia: Preliminary Findings from an Exploratory Study
- (2016) Mohamed Kouni Chahed et al. PLoS Neglected Tropical Diseases
- Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi
- (2016) Guilherme Curty Lechuga et al. International Journal for Parasitology-Drugs and Drug Resistance
- Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents
- (2016) Vineetha Mandlik et al. PLoS One
- Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochromebc1Complex of Plasmodium falciparum
- (2015) Allison M. Stickles et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Population Pharmacokinetics of Benznidazole in Adult Patients with Chagas Disease
- (2015) D. Soy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Therapeutic efficacy of artemisinin-loaded nanoparticles in experimental visceral leishmaniasis
- (2015) Muzamil Yaqub Want et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Anti-biofilm activity of biogenic selenium nanoparticles and selenium dioxide against clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, and Proteus mirabilis
- (2015) Mojtaba Shakibaie et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
- (2015) Carlos A. Morillo et al. NEW ENGLAND JOURNAL OF MEDICINE
- 4-Nitrobenzaldehyde thiosemicarbazone: a new compound derived from S-(-)-limonene that induces mitochondrial alterations in epimastigotes and trypomastigotes of Trypanosoma cruzi
- (2015) ELIZANDRA APARECIDA BRITTA et al. PARASITOLOGY
- Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro
- (2015) Elisangela Oliveira Freitas et al. PLoS One
- Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis
- (2015) Elisangela Oliveira Freitas et al. PLoS Neglected Tropical Diseases
- Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach
- (2015) Mathias Beig et al. PLoS Neglected Tropical Diseases
- Advances in Development of New Treatment for Leishmaniasis
- (2015) Juliana Perrone Bezerra de Menezes et al. Biomed Research International
- Folate metabolic pathways inLeishmania
- (2015) Tim J. Vickers et al. Essays in Biochemistry
- Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity
- (2015) Leonel A. Cortes et al. PLoS One
- Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease
- (2014) Guzmán Álvarez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
- (2014) Advait S. Nagle et al. CHEMICAL REVIEWS
- Therapeutical approaches under investigation for treatment of Chagas disease
- (2014) Maria Terezinha Bahia et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A new approach for the delivery of artemisinin: Formulation, characterization, and ex-vivo antileishmanial studies
- (2014) Muzamil Yaqub Want et al. JOURNAL OF COLLOID AND INTERFACE SCIENCE
- Acute Chagas Disease: New Global Challenges for an Old Neglected Disease
- (2014) Daniela V. Andrade et al. PLoS Neglected Tropical Diseases
- Trypanocide Treatment of Women Infected with Trypanosoma cruzi and Its Effect on Preventing Congenital Chagas
- (2014) Diana L. Fabbro et al. PLoS Neglected Tropical Diseases
- Chagas Disease and the London Declaration on Neglected Tropical Diseases
- (2014) Rick L. Tarleton et al. PLoS Neglected Tropical Diseases
- Squalene Synthase As a Target for Chagas Disease Therapeutics
- (2014) Na Shang et al. PLoS Pathogens
- Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure
- (2013) Momar Ndao et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase
- (2013) Mariana Ferrer-Casal et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines
- (2013) D C Swinney CLINICAL PHARMACOLOGY & THERAPEUTICS
- Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity
- (2013) Richard J. Hamill DRUGS
- Investigation of antileishmanial activities of Tio2@Ag nanoparticles on biological properties of L. tropica and L. infantum parasites, in vitro
- (2013) Adil M. Allahverdiyev et al. EXPERIMENTAL PARASITOLOGY
- A novel alkyl phosphocholine-dinitroaniline hybrid molecule exhibits biological activity in vitro against Leishmania amazonensis
- (2013) Joseane Lima Prado Godinho et al. EXPERIMENTAL PARASITOLOGY
- Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches
- (2013) Ian H. Gilbert JOURNAL OF MEDICINAL CHEMISTRY
- Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease
- (2013) Martine Keenan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study
- (2013) Monica Coelho Andrade et al. Revista da Sociedade Brasileira de Medicina Tropical
- Assessment of the quality of life of patients with cutaneous leishmaniasis in Belo Horizonte, Brazil, 2009-2010. A pilot study
- (2013) A. C. d. C. Toledo et al. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
- 2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase
- (2012) Carlos A. Rodrígues-Poveda et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacological Characterization, Structural Studies, andIn VivoActivities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib
- (2012) Frederick S. Buckner et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis
- (2012) Thomas P. C. Dorlo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Trypanosoma cruzi Antioxidant Enzymes As Virulence Factors in Chagas Disease
- (2012) Lucía Piacenza et al. ANTIOXIDANTS & REDOX SIGNALING
- Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease
- (2012) Arvind K Chavali et al. BMC Systems Biology
- Oral Transmission of Chagas Disease
- (2012) M. A. Shikanai-Yasuda et al. CLINICAL INFECTIOUS DISEASES
- Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase
- (2012) Bruno Demoro et al. DALTON TRANSACTIONS
- Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents
- (2012) Marion Recher et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis
- (2012) T. P. C. Dorlo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors
- (2012) Paola Corona et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase
- (2012) Srinivas Aripirala et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern
- (2012) M. MAROLI et al. MEDICAL AND VETERINARY ENTOMOLOGY
- Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects
- (2012) LAURA VIVIANA SÁNCHEZ et al. PARASITOLOGY
- Leishmaniasis Worldwide and Global Estimates of Its Incidence
- (2012) Jorge Alvar et al. PLoS One
- Mechanism of Amphotericin B Resistance in Clinical Isolates of Leishmania donovani
- (2011) Bidyut Purkait et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Overcoming multidrug resistance (MDR) in cancer in vitro and in vivo by a quinoline derivative
- (2011) Avishek Ganguly et al. BIOMEDICINE & PHARMACOTHERAPY
- Synthesis, trypanocidal activity and molecular modeling studies of 2-alkylaminomethylquinoline derivatives
- (2011) Gisela C. Muscia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antimicrobial effects of TiO2and Ag2O nanoparticles against drug-resistant bacteria andleishmaniaparasites
- (2011) Adil M Allahverdiyev et al. Future Microbiology
- Antileishmanial effect of silver nanoparticles and their enhanced antiparasitic activity under ultraviolet light
- (2011) Adil Allahverdiyev et al. International Journal of Nanomedicine
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Heme-Induced ROS in Trypanosoma Cruzi Activates CaMKII-Like That Triggers Epimastigote Proliferation. One Helpful Effect of ROS
- (2011) Natália Pereira de Almeida Nogueira et al. PLoS One
- Congenital Chagas Disease: Recommendations for Diagnosis, Treatment and Control of Newborns, Siblings and Pregnant Women
- (2011) Yves Carlier et al. PLoS Neglected Tropical Diseases
- Chagas disease: Present status of pathogenic mechanisms and chemotherapy
- (2010) Juan Diego Maya et al. BIOLOGICAL RESEARCH
- Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids
- (2010) Ioannis Papanastasiou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties
- (2010) Sumesh Eswaran et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Efficacy of artemisinin in experimental visceral leishmaniasis
- (2010) Rupashree Sen et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Mechanism of interaction of sitamaquine with Leishmania donovani
- (2010) E. S. Coimbra et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy
- (2010) Katrien Brak et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amphotericin B Membrane Action: Role for Two Types of Ion Channels in Eliciting Cell Survival and Lethal Effects
- (2010) B. Eleazar Cohen JOURNAL OF MEMBRANE BIOLOGY
- Chagas disease
- (2010) Anis Rassi et al. LANCET
- Miltefosine Promotes IFN- -Dominated Anti-Leishmanial Immune Response
- (2009) P. Wadhone et al. JOURNAL OF IMMUNOLOGY
- The p110 Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells
- (2009) D. Liu et al. JOURNAL OF IMMUNOLOGY
- On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
- (2009) Anna Neumann et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Design and Synthesis of Potent Antileishmanial Cycloalkylidene-Substituted Ether Phospholipid Derivatives
- (2008) Theodora Calogeropoulou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Purification and biochemical characterization of four iron superoxide dismutases in Trypanosoma cruzi
- (2008) Héctor Mateo et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
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