Trojan Horse Delivery of 4,4′‐Dimethoxychalcone for Parkinsonian Neuroprotection

Generation of a Novel Mouse Model of Parkinson’s Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra

(2020) Yunlong Zhang et al.   ACS Chemical Neuroscience

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease

(2020) Jingyi Liu et al.   ACS Nano

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia

(2020) Ichiro Kawahata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa

(2020) Roberto Cilia et al.   BRAIN

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease

(2020) Wenlong Zhang et al.   Cell Death & Disease

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

(2020) Yutong Zhou et al.   Science Advances

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

A metabolic profile of polyamines in parkinson disease: A promising biomarker

(2019) Shinji Saiki et al.   ANNALS OF NEUROLOGY

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson’s Disease

(2019) Xue Jiang et al.   Oxidative Medicine and Cellular Longevity

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

(2019) Arnaud Tauffenberger et al.   Cell Death & Disease

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

(2019) Eleni Samaridou et al.   BIOMATERIALS

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

(2018) Linhao You et al.   ACS Nano

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats

(2018) Sunaina Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson’s progression: Evidence from clinical studies and neurotoxin models

(2018) M.E. Johnson et al.   PROGRESS IN NEUROBIOLOGY

Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases?

(2018) Telma Bezerra Soares et al.   PROGRESS IN NEUROBIOLOGY

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice

(2018) Sherehan M. Ibrahim et al.   Scientific Reports

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

(2017) Rob C Oslund et al.   Nature Chemical Biology

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

(2017) Yunlong Zhang et al.   Cell Death & Disease

Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model

(2017) Shuiqin Niu et al.   Theranostics

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles

(2016) Sukru Gokhan Elci et al.   ACS Nano

Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity

(2016) Neal K. Bennett et al.   BIOMATERIALS

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells

(2016) Yutaro Obara et al.   CELLULAR SIGNALLING

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer’s Disease

(2015) Meng Huang et al.   ACS Nano

Dopamine or biopterin deficiency potentiates phosphorylation at 40 Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

(2015) Ichiro Kawahata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

Spermidine protects against α-synuclein neurotoxicity

(2014) Sabrina Büttner et al.   CELL CYCLE

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson’s disease

(2014) Marion Szelechowski et al.   Nature Communications

Role of GLUT1 in regulation of reactive oxygen species

(2014) Stanley Andrisse et al.   Redox Biology

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism

(2013) D. Rylander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance

(2012) Bing Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

A novel neuroprotective therapy for Parkinson’s disease using a viral noncoding RNA that protects mitochondrial Complex I activity

(2011) Wei-Li Kuan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2

(2011) Xiao Shi et al.   JOURNAL OF NEUROCHEMISTRY

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap

(2010) Paolo Calabresi et al.   LANCET NEUROLOGY

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson’s disease: an anatomical study

(2009) Estifanos Ghebremedhin et al.   ACTA NEUROPATHOLOGICA

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

ERK5 Activity Is Required for Nerve Growth Factor-induced Neurite Outgrowth and Stabilization of Tyrosine Hydroxylase in PC12 Cells

(2009) Yutaro Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY