Review
Health Care Sciences & Services
Gyrid Nygaard, Peter D. Szigetvari, Ann Kari Grindheim, Peter Ruoff, Aurora Martinez, Jan Haavik, Rune Kleppe, Marte Flydal
Summary: Dopa-responsive dystonia (DRD) is a rare movement disorder linked to defective dopamine synthesis, mainly associated with mutations in the GCH1 gene. However, some patients do not respond well to L-DOPA treatment, especially in severe cases of TH deficiency. This highlights the need for more effective and personalized treatment options.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Summary: This study found that the TH-DA pathway plays a critical role in the pathogenesis of Parkinson's disease. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and the balance between them affects the survival of DA neurons. Mutations in LRRK2 or PINK1 can disrupt this balance, leading to the demise of DA neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Clinical Neurology
Xin-yao Li, Ying-mai Yang, Li-bo Li, Meng-yu Zhang, Yang-yu Huang, Jie Wang, Lin Wang, Xin-hua Wan
Summary: This study summarized the clinical characteristics and long-term outcomes in patients with dopa-responsive dystonia who were treated with levodopa. Most patients showed satisfactory treatment outcomes after long-term levodopa, while a few patients with specific variants developed new motor symptoms, possibly due to dopamine insufficiency. Increasing levodopa dose slowly may be helpful for patients with motor symptoms after long-term treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Alba Tristan-Noguero, Irene Fernandez-Carasa, Carles Calatayud, Cristina Bermejo-Casadesus, Meritxell Pons-Espinal, Arianna Colini Baldeschi, Leticia Campa, Francesc Artigas, Analia Bortolozzi, Rosario Domingo-Jimenez, Salvador Ibanez, Merce Pineda, Rafael Artuch, Angel Raya, Angels Garcia-Cazorla, Antonella Consiglio
Summary: This study used induced pluripotent stem cells (iPSCs) to generate dopaminergic neurons (DAn) from patients with tyrosine hydroxylase deficiency (THD) and compared them with control-DAn. THD iPSC-DAn showed lower levels of dopamine metabolites and reduced TH expression compared to controls. Additionally, THD iPSC-DAn displayed abnormal morphology and neuronal defects, which were rescued by L-Dopa treatment only in the milder form of THD (THD-A). Treatment at the stage of neuronal precursors could prevent the alterations in the severe form of THD (THD-B). This iPSC-based model recapitulates THD disease phenotypes and response to treatment.
EMBO MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Giulia Costa, Francesca Felicia Caputi, Marcello Serra, Nicola Simola, Laura Rullo, Serena Stamatakos, Fabrizio Sanna, Marc Germain, Maria-Grazia Martinoli, Sanzio Candeletti, Micaela Morelli, Patrizia Romualdi
Summary: The study found that MDMA has toxic effects on the dopaminergic nigrostriatal system, and these effects are influenced by sex, with male dopaminergic neurons being more sensitive to SOD2 and UPS-mediated toxic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu
Summary: Parkinson's disease is an aging-related neurodegenerative disease characterized by movement disorders and deficiency of dopamine. Lewy bodies and abnormal accumulation of neuromelanin are the histopathological hallmarks of Parkinson's disease, leading to cell death of dopamine neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Mohamad Ayajuddin, Rahul Chaurasia, Abhik Das, Priyanka Modi, Limamanen Phom, Zevelou Koza, Sarat Chandra Yenisetti
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. Using a fly model, our laboratory has shown that there is a reduction in fluorescence intensity of secondary antibodies targeting tyrosine hydroxylase, indicating a decrease in dopamine synthesis and dysfunction of dopaminergic neurons. This quantification method of fluorescence intensity can be a sensitive and cost-effective approach for studying neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Yilin Wang, Chunmei Wang, Meiyan Liu, Wuhen Xu, Simei Wang, Fang Yuan, Xiaona Luo, Quanmei Xu, Rongrong Yin, Anqi Wang, Miao Guo, Longlong Lin, Chao Wang, Hongyi Cheng, Zhiping Liu, Yuanfeng Zhang, Fanyi Zeng, Jingbin Yan, Yucai Chen
Summary: This study analyzed the clinical data of seven Segawa syndrome patients and found that three patients had the same homozygous mutation in the TH gene as previously reported, while two new mutations were found in other patients. Real-time quantitative polymerase chain reaction analysis showed that the TH gene expression was lower in two patients compared to normal controls, and the expression level was also lower in one mother. The study suggests that TH gene mutations may lead to Segawa syndrome by affecting dopamine and catecholamine production.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Olga Buneeva, Alexei Medvedev
Summary: Ubiquitination is a major post-translational modification of proteins, and atypical ubiquitination plays a crucial role in the development of Parkinson's disease, targeting proteins involved in the disease mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Carissa A. Hansen, Douglas R. Miller, Stephanie Annarumma, Carley T. Rusch, Adolfo Ramirez-Zamora, Habibeh Khoshbouei
Summary: This manuscript provides a comprehensive review of treatment protocols, absorption, distribution, and drug/food interactions related to L-DOPA-induced dyskinesia, and discusses current strategies and future directions.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Maryam Sadat Jalali, Alireza Sarkaki, Yaghoub Farbood, Seyed Saeed Azandeh, Esrafil Mansouri, Mohammad Ghasemi Dehcheshmeh, Ghasem Saki
Summary: The study showed that in the Parkinson's disease model, motor activities, the number of dopaminergic neurons, and levels of dopamine and tyrosine hydroxylase were all improved in the treated groups compared to the Parkinson's disease group.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Neurosciences
Waijiao Cai, Kazumasa Wakamatsu, Fabio A. Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Chen
Summary: By studying samples of substantia nigra from patients with Parkinson's disease, we found increased ratios of pheomelanin to dopamine in the melanin content, as well as reduced levels of eumelanins derived from both DOPA and dopamine. Additionally, an increase in pheomelanin relative to dopamine pheomelanin was observed in Parkinson's disease. These findings provide insights into the roles of pheomelanin and eumelanin in the pathophysiology of Parkinson's disease.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Nanoscience & Nanotechnology
Qi Shang, Ling Zhang, Chan Chen, Weikang Tang, Mengqi Han, Qinfei Chen, Wenbin Liu
Summary: This study developed a nanozyme based on ethylenediaminetetraacetic acid (EDTA)-Fe2+ complex decorated Fe3O4 magnetic nanoparticles for biomimetic synthesis of L-DOPA. The nanozyme exhibited high catalytic performance, good reusability, and potential applications in the low-cost and high-efficiency production of L-DOPA.
ACS APPLIED NANO MATERIALS
(2022)
Article
Clinical Neurology
Jun Ikezawa, Rui Shimazaki, Shinsuke Tobisawa, Keizo Sugaya, Kazushi Takahashi
Summary: SCA6 typically presents with cerebellar ataxia and rarely with extra-pyramidal symptoms. We report the first case of SCA6 with dopa-responsive dystonia. A 75-year-old woman presented with progressive cerebellar ataxia and dystonia in the left upper limb. Genetic testing confirmed SCA6 diagnosis. Oral levodopa improved her dystonia, allowing her to raise her left hand. Oral levodopa may be beneficial in the early treatment of SCA6-associated dystonia.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Ophthalmology
Fusao Kawai, Mahito Ohkuma, Masayuki Horiguchi, Hiroshi Ichinose, Ei-ichi Miyachi
Summary: Some human bipolar cells express SCN2A Na+ channel, which may amplify the release of neurotransmitter glutamate when the membrane potential is rapidly depolarized, selectively accelerating light responses.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga
Summary: The study demonstrates that FABP7 triggers alpha-synuclein oligomerization through oxidative stress, while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation, thereby rescuing glial cells and oligodendrocytes from cell death.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
An Cheng, Wenbin Jia, Ichiro Kawahata, Kohji Fukunaga
Summary: Synucleinopathies are a group of diverse diseases that can cause motor and cognitive dysfunction due to progressive neuronal loss or demyelination, often found in diseases like Parkinson's and dementia with Lewy bodies. Mitochondrial injury plays a crucial role in neuronal loss and oligodendrocyte dysfunction in these neurodegenerative disorders, with alpha-synuclein accumulation in the mitochondrial membrane being a key factor.
Article
Neurosciences
Kazuya Matsuo, Ichiro Kawahata, Ronald Melki, Luc Bousset, Yuji Owada, Kohji Fukunaga
Summary: This study demonstrates the crucial role of fatty acid-binding protein 3 (FABP3) in pathogenic alpha-synuclein accumulation and its seeding ability, showing that the deletion of FABP3 can reduce the accumulation of exogenous alpha-synuclein in the substantia nigra pars compacta and attenuate motor impairments. These results suggest that FABP3 could be a potential therapeutic target against alpha-synuclein propagation in synucleinopathies.
Article
Biochemistry & Molecular Biology
Jing Xu, Ichiro Kawahata, Hisanao Izumi, Kohji Fukunaga
Summary: SAK3 activates CaMKII to enhance proteasomal activity, leading to the degradation of α-Syn and slowing down the progression of LBD. This study reveals the promoting effect of SAK3 on α-Syn pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Ichiro Kawahata, Kohji Fukunaga
Summary: An aging society leads to an increased number of patients with cognitive and movement disorders. This review focuses on the role of FABP3, dopamine receptors, and other FABP family proteins in the process of alpha-synuclein propagation and the subsequent aggregate-induced cytotoxicity, and proposes the potential of FABP as a therapeutic target for alpha-synucleinopathies.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
An Cheng, Wenbin Jia, Ichiro Kawahata, Kohji Fukunaga
Summary: The study demonstrated that MF 6 has potential therapeutic effects in multiple sclerosis by reducing myelin loss and clinical symptoms, as well as decreasing oxidative stress levels and specific cell types in the spinal cord. Additionally, MF 6 showed protective functions for mitochondria in oligodendrocytes through FABP5 inhibition, suggesting a promising role in immune inhibition and oligodendrocyte protection in MS therapy.
Review
Biochemistry & Molecular Biology
Ichiro Kawahata, David Finkelstein, Kohji Fukunaga
Summary: alpha-Synuclein is a protein associated with Parkinson's disease, and its phosphorylation and aggregation play a crucial role in disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, An Cheng, Wenbin Jia, Haoyang Wang, Kohji Fukunaga
Summary: Stroke is a leading cause of death and disability worldwide, but effective neuroprotective therapies for ischemic stroke patients are lacking. Lipids play important roles in the pathogenesis of neurological diseases, and fatty acid-binding proteins (FABPs) have been found to be involved in neurodegenerative diseases. However, FABPs' roles in ischemic stroke have received comparatively little attention. In this review, we summarize the literature on the associations between FABPs and ischemia and propose potential therapeutic targets for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hideki Oizumi, Yoko Sugimura, Tomoko Totsune, Iori Kawasaki, Saki Ohshiro, Toru Baba, Teiko Kimpara, Hiroaki Sakuma, Takafumi Hasegawa, Ichiro Kawahata, Kohji Fukunaga, Atsushi Takeda
Summary: Recent research has shown that lipid metabolism abnormalities play a significant role in the development of neurodegenerative diseases. In this study, plasma lipids were examined using lipidomics in individuals with neurodegenerative diseases and healthy controls. The results revealed decreased levels of plasma sphingosine-1-phosphate (S1P) and increased levels of plasma monohexylceramide (MonCer) and lactosylceramide (LacCer) in neurodegenerative disease patients. These findings highlight the importance of abnormal sphingolipid metabolism in neurodegeneration.
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Ichiro Kawahata, Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Haoyang Wang, Kohji Fukunaga, An Cheng, Yifei Wang, Nariko Arimura, Hiroshi Yoshino, Takuya Sasaki, Ichiro Kawahata
Summary: Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc) caused by aSyn toxicity. This study developed a novel FABP3 ligand, HY-11-9, which showed improved therapeutic effects in a PD mouse model compared to a previous ligand, MF1. HY-11-9 significantly improved motor deficits and neuropathological deterioration induced by MPTP, suggesting its potential as a PD therapy.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ichiro Kawahata, Kohji Fukunaga
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction caused by the degeneration of dopamine-producing neurons. Fatty acid-binding proteins (FABPs) play a significant role in the pathogenesis of Parkinson's disease, accumulating in cells and disrupting their normal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Naoya Fukui, Hanae Yamamoto, Moe Miyabe, Yuki Aoyama, Kunihiro Hongo, Tomohiro Mizobata, Ichiro Kawahata, Yasushi Yabuki, Yasuharu Shinoda, Kohji Fukunaga, Yasushi Kawata
Summary: The study found that the binding of FABP3 protein to αSyn protein alters the aggregation mechanism of αSyn, enhancing its cytotoxicity towards cells, and can be disrupted by αSynP130-140. This discovery may help prevent the accumulation of toxic FABP3-αSyn oligomers in cells, thereby halting the progression of Parkinson's disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)