Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia

Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain

(2020) Yasushi Yabuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetics of Parkinson's disease: An introspection of its journey towards precision medicine

(2020) Sara Bandres-Ciga et al.   NEUROBIOLOGY OF DISEASE

Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice

(2020) Hidaka Haga et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?

(2019) David P. Breen et al.   MOVEMENT DISORDERS

Plasma alpha-synuclein detected by single molecule array is increased in PD

(2019) Adeline S. L. Ng et al.   Annals of Clinical and Translational Neurology

Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice

(2019) Kazuya Matsuo et al.   NEUROPHARMACOLOGY

Tyrosine hydroxylase phosphorylation in vivo

(2019) Peter R. Dunkley et al.   JOURNAL OF NEUROCHEMISTRY

Dystonia and Parkinson's disease: What is the relationship?

(2019) Aakash S. Shetty et al.   NEUROBIOLOGY OF DISEASE

Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1–assisted dopamine transporter endocytosis

(2019) Junpei Kobayashi et al.   FASEB JOURNAL

Parkinson’s Disease in Women and Men: What’s the Difference?

(2019) Silvia Cerri et al.   Journal of Parkinsons Disease

Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

(2019) Ichiro Kawahata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and lysosomal pathways in nervous system disorders

(2018) Baris Bingol   MOLECULAR AND CELLULAR NEUROSCIENCE

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease

(2018) Feng Lai et al.   NEUROCHEMICAL RESEARCH

Dystonia

(2018) Bettina Balint et al.   Nature Reviews Disease Primers

Dopamine Agonists for Pituitary Adenomas

(2018) Odelia Cooper et al.   Frontiers in Endocrinology

Protein synthesis and quality control in aging

(2018) Aleksandra S. Anisimova et al.   Aging-US

Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis

(2018) Ichiro Kawahata et al.   Journal of Functional Foods

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization

(2018) An Cheng et al.   BRAIN RESEARCH

Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4′-demethylnobiletin prevents MK801-induced memory impairment

(2017) Ichiro Kawahata et al.   Journal of Natural Medicines

V-1/CP complex formation is required for genetic co-regulation of adult nigrostriatal dopaminergic function via the RHO/MAL/SRF pathway in vitro and in vivo

(2017) I. Kawahata et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

(2017) Marion Delenclos et al.   Frontiers in Neuroscience

Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice

(2016) Michael F. Salvatore et al.   ACS Chemical Neuroscience

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells

(2016) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2016) Lauren Hirsch et al.   NEUROEPIDEMIOLOGY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity

(2016) Anne Baumann et al.   Scientific Reports

Parkinson's disease as a result of aging

(2015) Manuel Rodriguez et al.   AGING CELL

The genetics of the dystonias – a review based on the new classification of the dystonias

(2015) Carlos Henrique F. Camargo et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Dopamine or biopterin deficiency potentiates phosphorylation at 40 Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

(2015) Ichiro Kawahata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

The autophagy-lysosomal pathway

(2015) Daniel L. Kenney et al.   NEUROLOGY

Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension

(2015) Nadia A. Longo Carbajosa et al.   PLoS One

Autophagy as a Possible Underlying Mechanism of Nanomaterial Toxicity

(2014) Vanessa Cohignac et al.   Nanomaterials

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action

(2013) Ichiro Kawahata et al.   JOURNAL OF NEURAL TRANSMISSION

Expanding the clinical phenotype of DYT5 mutations: Is multiple system atrophy a possible one?

(2013) R. Ceravolo et al.   NEUROLOGY

From prediction error to incentive salience: mesolimbic computation of reward motivation

(2012) Kent C. Berridge   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme

(2011) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases

(2010) C. E. Teunissen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo

(2010) Haiyan Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurobiological Substrates of Tourette's Disorder

(2010) James F. Leckman et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Levodopa in the treatment of Parkinson’s disease: an old drug still going strong

(2010) Angelo Antonini   Clinical Interventions in Aging

A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease

(2009) Weiming Xia et al.   ARCHIVES OF NEUROLOGY

Amyloid β peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing

(2009) P. Lewczuk et al.   EXPERIMENTAL NEUROLOGY

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells

(2009) Ichiro Kawahata et al.   JOURNAL OF NEURAL TRANSMISSION

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Long-term up-regulation of the level of phosphorylated tyrosine hydroxylase by depletion of dopamine or biopterin

(2009) Ichiro Kawahata et al.   NEUROSCIENCE RESEARCH

A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice—as a mouse model for Parkinson’s disease

(2008) Chisato Takazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

(2008) Marta Martinez-Vicente et al.   JOURNAL OF CLINICAL INVESTIGATION

α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

(2008) Tshianda N.M. Alerte et al.   NEUROSCIENCE LETTERS

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING