Article
Biochemistry & Molecular Biology
Skylar E. Davis, Jonathan R. Roth, Qays Aljabi, Ahmad R. Hakim, Katherine E. Savell, Jeremy J. Day, Andrew E. Arrant
Summary: Loss-of-function mutations in progranulin are a major genetic cause of frontotemporal dementia, with the neurotrophic and antiinflammatory effects of progranulin potentially contributing to this. The protective effects of progranulin against excitotoxicity are likely mediated through lysosomes, specifically through the autophagy-lysosomal pathway. Lysosome-targeted progranulin showed more consistent protective effects, indicating a mechanistic link between progranulin's lysosomal and neurotrophic effects.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mariano Catanesi, Laura Brandolini, Michele D'Angelo, Maria Grazia Tupone, Elisabetta Benedetti, Margherita Alfonsetti, Massimiliano Quintiliani, Maddalena Fratelli, Daniela Iaconis, Annamaria Cimini, Vanessa Castelli, Marcello Allegretti
Summary: S-carboxymethylcysteine is widely used as an expectorant for respiratory disorders, with complex metabolic fate influenced by genetic polymorphism. Different individuals may have varying metabolism of the drug, leading to different effects upon night-time and daytime administration, potentially beneficial for Parkinson's disease patients.
Article
Multidisciplinary Sciences
Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, Warren D. Hirst
Summary: ITPKB is negatively regulating alpha-synuclein aggregation by inhibiting ER-to-mitochondria calcium transport, suggesting modulation of this pathway as a potential therapeutic strategy for sporadic PD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Chen Ding, Youjun Wu, Hadas Dabas, Marc Hammarlund
Summary: Mitochondrial defects are closely linked to axon degeneration. This study reveals that activation of CaMKII can suppress axon degeneration caused by loss of mitochondria, and this protection is mediated by the Sarm1-p38 MAPK pathway and the transcription factor CEBP-1. Disrupting a trafficking complex also inhibits axon degeneration by activating the CaMKII-Sarm1-MAPK pathway through L-type voltage-gated calcium channels.
Article
Microbiology
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno
Summary: This study investigates the synthesis of polyprenyl diphosphate in Toxoplasma gondii and identifies the enzyme TgCoq1 as a key player in this process. The growth of TgCoq1 mutants is impaired, but can be rescued by complementation with a homologous gene or a related enzyme. Additionally, a bisphosphonate is found to inhibit T. gondii growth, which can be reversed by supplementation with long-chain ubiquinone. Importantly, the bisphosphonate also protects mice against lethal T. gondii infection.
Article
Biochemistry & Molecular Biology
Mariano Catanesi, Laura Brandolini, Michele d'Angelo, Elisabetta Benedetti, Maria Grazia Tupone, Margherita Alfonsetti, Enrico Cabri, Daniela Iaconis, Maddalena Fratelli, Annamaria Cimini, Vanessa Castelli, Marcello Allegretti
Summary: Methionine has been shown to play important roles in metabolism, immunity, and antioxidant enzyme activation. Methionine restriction can help prevent DNA damage and neurodegenerative processes. Additionally, an L-methionine-enriched diet may protect neurons during aging by maintaining mitochondrial functionality and preventing oxidative imbalance.
Article
Biochemistry & Molecular Biology
Yuki Kasamo, Kiyoshi Kikuchi, Munekazu Yamakuchi, Shotaro Otsuka, Seiya Takada, Yuki Kambe, Takashi Ito, Ko-ichi Kawahara, Kazunori Arita, Koji Yoshimoto, Ikuro Maruyama
Summary: Mitochondrial functional abnormalities or quantitative decreases are considered key pathogenic mechanisms of Parkinson's disease. This study found that 1,5-anhydro-D-fructose (1,5-AF) had protective effects against rotenone-induced cytotoxicity by upregulating PGC-1 alpha through AMPK activation, leading to mitochondrial biogenic and cytoprotective effects. These results suggest that 1,5-AF has therapeutic potential for Parkinson's disease treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Bao-ping Zhang, Li Wu, Xian-wei Wu, Fang Wang, Xin Zhao
Summary: This study investigated the effect of dexmedetomidine on inhibiting proinflammatory mediators regulated by NF-KB, improving dopamine levels, and reducing degeneration of dopaminergic neurons in the substantianigra pars compacta in a Parkinson's disease mouse model.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Article
Neurosciences
Jayanth Anantha, Susan R. Goulding, Eszter Tuboly, Adam G. O'Mahony, Gerard M. Moloney, Gareth Lomansey, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: Parkinson's disease is a neurodegenerative disease characterized by the progressive degeneration of midbrain dopaminergic neurons and axonal degeneration. Research suggests that the neurotrophic factor NME1 may have potential as a therapeutic agent for axonal protection in PD, enhancing mitochondrial function and promoting neurite growth in cell models.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Immunology
Lianpan Dai, George F. Gao
Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenyong Ding, Minghua Qi, Li Ma, Xuefei Xu, Yingfei Chen, Wenli Zhang
Summary: The study revealed that ANT1 is potentially involved in the pathogenesis of Parkinson's disease (PD) by promoting the formation of protein aggregates with alpha-synuclein, leading to neurodegenerative injury. Additionally, ANT1 supplementation in neuronal cells showed protective roles against MPP+-induced cytotoxicity. This investigation advances the understanding of ANT1 in PD etiology and provides valuable insights for potential drug targets and biomarkers in PD management.
CELL AND BIOSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Mingming Tong, Toshiro Saito, Peiyong Zhai, Shin-Ichi Oka, Wataru Mizushima, Michinari Nakamura, Shohei Ikeda, Akihiro Shirakabe, Junichi Sadoshima
Summary: The study found that during the chronic phase of obesity-associated cardiomyopathy, mitophagy is activated even after conventional autophagy is downregulated, serving as an essential mitochondrial quality control mechanism to protect the heart.
CIRCULATION RESEARCH
(2021)
Article
Neurosciences
G. Carola, D. Malagarriga, C. Calatayud, M. Pons-Espinal, L. Blasco-Agell, Y. Richaud-Patin, I. Fernandez-Carasa, V. Baruffi, S. Beltramone, E. Molina, P. Dell'Era, J. J. Toledo-Aral, E. Tolosa, A. R. Muotri, J. Garcia Ojalvo, J. Soriano, A. Raya, A. Consiglio
Summary: This study reveals that early dysfunction in neuronal networks in Parkinson’s disease may initiate downstream degenerative pathways before dopamine neuron loss, providing a potential window of opportunity for pre-symptomatic assessment of chronic degenerative diseases.
NPJ PARKINSONS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Britney N. Lizama, Charleen T. Chu
Summary: Autophagy is crucial for cells to remove damaged components and is increasingly studied for its role in various diseases. Research on autophagy and mitochondrial quality control is expanding, particularly in relation to conditions like cancer, immune diseases, and neurodegenerative diseases.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Adrien Casanova, Marie-Charline Blatche, Cecile A. Ferre, Helene Martin, Daniel Gonzalez-Dunia, Liviu Nicu, Guilhem Larrieu
Article
Neurosciences
Macarena S. Arrazola, Trinovita Andraini, Marion Szelechowski, Lionel Mouledous, Laetitia Arnaune-Pelloquin, Noelie Davezac, Pascale Belenguer, Claire Rampon, Marie-Christine Miquel
NEUROTOXICITY RESEARCH
(2019)
Article
Multidisciplinary Sciences
Benjamin Lassus, Jeremie Naude, Philippe Faure, Denis Guedin, Ysander Von Boxberg, Clotilde Mannoury la Cour, Mark J. Millan, Jean-Michel Peyrin
SCIENTIFIC REPORTS
(2018)
Article
Cell & Tissue Engineering
Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Article
Multidisciplinary Sciences
Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Maude Rolland, Helene Martin, Mathilde Bergamelli, Yann Sellier, Bettina Bessieres, Jacqueline Aziza, Alexandra Benchoua, Marianne Leruez-Ville, Daniel Gonzalez-Dunia, Stephane Chavanas
Summary: Human cytomegalovirus (HCMV) infection leads to impaired migration of neural stem cells by increasing the expression of LIS1, resulting in developmental abnormalities and sequelae. Studies on infected NSCs suggest that PAFAH1B1 is a critical target of HCMV infection, shedding new light on the pathophysiological basis of congenital HCMV infection's neurological outcomes.
JOURNAL OF PATHOLOGY
(2021)
Letter
Immunology
Karine Bourgade, Anne Thouard, Florence Abravanel, Anne-Laure Hebral, Arnaud Del Bello, Alain Viguier, Daniel Gonzalez-Dunia, Nassim Kamar
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Cell Biology
Mathilde Bergamelli, Helene Martin, Melinda Benard, Jerome Ausseil, Jean-Michel Mansuy, Ilse Hurbain, Mailys Mouysset, Marion Groussolles, Geraldine Cartron, Yann Tanguy le Gac, Nathalie Moinard, Elsa Suberbielle, Jacques Izopet, Charlotte Tscherning, Graca Raposo, Daniel Gonzalez-Dunia, Gisela D'Angelo, Cecile E. Malnou
Summary: Extracellular vesicles (EVs) play important roles during pregnancy, serving as both potential biomarkers and mediators in communication between the placenta and maternal/fetal sides. Infection can alter the expression levels of surface markers on EVs, while still maintaining their secretion and integrity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Florent Henri Marty, Luca Bettamin, Anne Thouard, Karine Bourgade, Sophie Allart, Guilhem Larrieu, Cecile Evelyne Malnou, Daniel Gonzalez-Dunia, Elsa Suberbielle
Summary: In this study, it was found that Borna disease virus infection or expression of viral nucleoprotein and phosphoprotein increased DNA double-strand break (DSB) levels in neurons. Inducing DSB promoted the recruitment of viral replication centers colocalized with DSB and enhanced viral RNA replication. BoDV-1 persistence decreased neuronal activity and response to stimulation by reducing the surface expression of glutamate receptors. These findings suggest a novel mechanistic cross talk between RNA virus persistence and neuronal function through the control of DSB levels.
Article
Acoustics
Nathan Jeger-Madiot, Xavier Mousset, Chloe Dupuis, Lucile Rabiet, Mauricio Hoyos, Jean-Michel Peyrin, Jean-Luc Aider
Summary: A multi-node acoustofluidic chip has been designed for cell manipulations, operating on a broadband spectrum and beyond the resonance condition. Utilizing a one-dimensional multi-layer model, the study describes the generation of stationary standing waves inside a cavity, through the transmission and reflection of acoustic waves across different layers and interfaces. The findings demonstrate a wide continuous operating range for the chip, allowing cell movement and merging by varying the acoustic frequency.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Cell Biology
Mirca S. Saurty-Seerunghen, Thomas Daubon, Lea Bellenger, Virgile Delaunay, Gloria Castro, Joris Guyon, Ahmed Rezk, Sylvie Fabrega, Ahmed Idbaih, Fabien Almairac, Fanny Burel-Vandenbos, Laurent Turchi, Eric Duplus, Thierry Virolle, Jean-Michel Peyrin, Christophe Antoniewski, Herve Chneiweiss, Elias A. El-Habr, Marie-Pierre Junier
Summary: Cell motility is critical for tumor malignancy. Analysis of transcriptomes from glioblastoma patients identified metabolic weaknesses shared by motile cells, characterized by enhanced mitochondrial load, oxidative stress, and dependence on increased ROS production and MPST activity for their motility.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Josquin Courte, Ngoc Anh Le, Teng Pan, Luc Bousset, Ronald Melki, Catherine Villard, Jean-Michel Peyrin
Summary: This study demonstrates the limited spreading of preformed aSyn aggregates and suggests that it occurs through molecular sieving of large aSyn seeds. The research also shows that synaptic connections do not facilitate this process. The development of a new microfluidic platform allows for the reconstruction of fully oriented neuronal networks in vitro, enabling the quantification of fluorescent aSyn aggregates spreading between neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Cecile A. Ferre, Anne Thouard, Alexandre Betourne, Anne-Louise Le Dorze, Pascale Belenguer, Marie-Christine Miquel, Jean-Michel Peyrin, Daniel Gonzalez-Dunia, Marion Szelechowski
Summary: The study demonstrated that Mortalin expression levels influence neuronal fate, with over-expression providing protection against rotenone-induced damage and down-regulation leading to mitochondrial fragmentation and axonal damage. Additionally, Mortalin levels were shown to modulate mitochondrial morphology through DRP1 phosphorylation, further emphasizing the crucial role of mitochondrial dynamics in neuronal fate in degenerative diseases.
SCIENTIFIC REPORTS
(2021)