Review
Biochemistry & Molecular Biology
Rebecca Maechtel, Fanni Annamaria Boros, Jan Philipp Dobert, Philipp Arnold, Friederike Zunke
Summary: Lysosomes are acidic organelles responsible for recycling cellular components and can cause lysosomal dysfunction and LSDs when there is reduced enzymatic activity. Neurons are particularly susceptible to lysosomal dysfunction, leading to neurological symptoms. There are genetic associations between LSDs and Parkinson's disease, indicating common cellular mechanisms.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Neurosciences
Laetitia Francelle, Joseph R. Mazzulli
Summary: This article reviews the relationship between lysosomal storage diseases (LSDs) and neurodegenerative diseases such as Parkinson's disease (PD), focusing on the role of glial cells and neuroinflammation. The study explains that lysosomal dysfunction and accumulation of storage materials can activate glial cells, but prolonged glial activation may lead to neuron loss. These findings provide new therapeutic approaches for the treatment of PD and LSDs.
Article
Geriatrics & Gerontology
Yu-wen Zhao, Hong-xu Pan, Zhenhua Liu, Yige Wang, Qian Zeng, Zheng-huan Fang, Teng-fei Luo, Kun Xu, Zheng Wang, Xun Zhou, Runcheng He, Bin Li, Guihu Zhao, Qian Xu, Qi-ying Sun, Xin-xiang Yan, Jie-qiong Tan, Jin-chen Li, Ji-feng Guo, Bei-sha Tang
Summary: The study demonstrated a significant association between rare variants in lysosomal storage disorder genes and Parkinson's disease in Chinese mainland patients, especially in familial or sporadic early-onset cases. Several novel risk genes were identified within LSD gene subgroups, showing genetic heterogeneity in early-onset and late-onset patients with PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
S. M. Cartella, C. Terranova, V. Rizzo, A. Quartarone, P. Girlanda
Summary: The article discusses the relationship between Covid-19 and Parkinson's Disease, focusing on five aspects: the increased risk of severe Covid-19 infection for frail, old, multi-pathological patients; the impact on PD patients' health and risk of developing severe Covid-19; the consequences of lockdown and restrictive measures on mental and cognitive health of patients and caregivers; considerations for patient care and management during this unprecedented time; and the possibility of Covid-19-induced parkinsonism.
JOURNAL OF NEUROLOGY
(2021)
Article
Biology
Marco Angelo Monte, Massimiliano Veroux, Margherita Stefania Rodolico, Valentina Losi, Luigi Di Pino, Rita Bella, Giuseppe Lanza, Ines Paola Monte
Summary: Fabry's disease patients exhibit wide phenotypic variability, even at single-organ level, likely due to individual genetic mutation, while a multidisciplinary approach can achieve early clinical detection and management compared to conventional methods.
Article
Cell Biology
Alice Prieto Huarcaya, Susy Drobny, Andre R. A. Marques, Alessandro Di Spiezio, Jan Philipp Dobert, Denise Balta, Christian Werner, Tania Rizo, Lisa Gallwitz, Simon Bub, Iva Stojkovska, Nandkishore R. Belur, Jens Fogh, Joseph R. Mazzulli, Wei Xiang, Amitkumar Fulzele, Mario Dejung, Markus Sauer, Beate Winner, Stefan Rose-John, Philipp Arnold, Paul Saftig, Friederike Zunke
Summary: This study suggests that enhancing SNCA degradation through the application of rHsCTSD can reduce SNCA aggregates in the brains of PD patients and restore endo-lysosome and autophagy function.
Article
Geriatrics & Gerontology
Eva Ntanasi, Maria Maraki, Mary Yannakoulia, Maria Stamelou, Georgia Xiromerisiou, Mary H. Kosmidis, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Antonios Gargalionis, Kostas Patas, Stylianos Chatzipanagiotou, Socrates Charisis, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study found an association between frailty and prodromal PD and PD, suggesting that frailty may impact the likelihood of older individuals developing these conditions, and indicating common characteristics or underlying mechanisms among them.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Gen Li, Pei Huang, Shishuang Cui, Yachao He, Yuyan Tan, Shengdi Chen
Summary: Long-term Tai Chi training in patients with Parkinson's disease showed maintenance of improvement in motor and non-motor symptoms, reducing the need for increasing antiparkinsonian therapies. The annual increase in levodopa equivalent daily dosage was significantly lower in the Tai Chi group, indicating the benefits of Tai Chi training on PD symptoms and complications.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Atul Goel, Ramkumar Sugumaran, Sunil K. Narayan
Summary: Parkinson's disease is a progressive neurodegenerative disease caused by a depletion of dopamine, with limited available therapies. Zonisamide may be a potential candidate to alleviate symptoms of PD, with evidence supporting its efficacy in motor symptoms as an adjunctive therapy but lacking for non-motor symptoms, requiring further investigation.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Naomi Hannaway, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Andreas-Antonios Roussakis, Jonathan Howard, Matthew B. Wall, Clare Loane, Roger A. Barker, Paola Piccini
Summary: The study found that there are changes over time in the blood-oxygen-level dependent response of Parkinson's disease patients undertaking a simple motor task. These changes primarily occur in the ipsilateral cerebellum and may be compensatory in nature.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Lara M. Lange, Paulina Gonzalez-Latapi, Rajasumi Rajalingam, Marina A. J. Tijssen, Darius Ebrahimi-Fakhari, Carolin Gabbert, Christos Ganos, Rhia Ghosh, Kishore R. Kumar, Anthony E. Lang, Malco Rossi, Sterre van Der Veen, Bart van de Warrenburg, Tom Warner, Katja Lohmann, Christine Klein, Connie Marras
Summary: This study presents a new system for naming genetically determined movement disorders and provides an updated list of newly confirmed monogenic causes of movement disorders. The classification of certain genetic conditions has been refined, and a new category of mixed movement disorders has been introduced. These updated lists serve as a valuable resource for clinicians and researchers.
MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Rosa Manzoli, Lorenzo Badenetti, Michela Rubin, Enrico Moro
Summary: This review discusses the crucial role of lysosomes in the regulation of axonal guidance cue delivery, localization, and function, providing evidence to understand the relationship between lysosomal storage disorders and neurodegenerative diseases.
Article
Genetics & Heredity
Erin T. Strovel, Kristina Cusmano-Ozog, Tim Wood, Chunli Yu
Summary: Assays that measure lysosomal enzyme activity are crucial for diagnosing and screening lysosomal storage disorders. This document provides guidance for clinical enzyme testing, including test performance variables and the need for follow-up molecular testing.
GENETICS IN MEDICINE
(2022)
Review
Neurosciences
Ali Shalash, Meredith Spindler, Esther Cubo
Summary: Telemedicine programs are well-suited for evaluating patients with Parkinson's disease and other movement disorders, especially in rural and underserved communities. Despite the challenges, the COVID-19 pandemic has highlighted the benefits of telemedicine in addressing ongoing healthcare needs and reducing in-person visits. Patients and clinicians are gaining more experience with telemedicine, which is facilitating equitable access to specialized care for PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Michael Lawton, Manuela M. X. Tan, Yoav Ben-Shlomo, Fahd Baig, Thomas Barber, Johannes C. Klein, Samuel G. Evetts, Stephanie Millin, Naveed Malek, Katherine Grosset, Roger A. Barker, Nigel Williams, David J. Burn, Thomas Foltynie, Huw R. Morris, Nicholas Wood, Donald G. Grosset, Michele Tao-Ming Hu
Summary: This study explores the genetics of four previously described subtypes of Parkinson's disease and finds associations between different subtypes and GBA gene mutations and genetic risk. These findings provide insights into the underlying disease mechanisms and pathogenesis in different subtypes of Parkinson's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)