Immunomodulatory Effects of Dietary Polyphenols

Mango (Mangifera indica L.) polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase Lactobacillus species in a pilot study in patients with inflammatory bowel disease

(2020) Hyemee Kim et al.   NUTRITION RESEARCH

Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2 Colon Cells

(2020) Rameshprabu Nallathambi et al.   Nutrients

Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential

(2020) Maria Karmella Apaya et al.   PHARMACOLOGICAL RESEARCH

Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB

(2020) Ji-Ye Lim et al.   MOLECULES

GREEN TEA: A POSSIBILITY IN THE THERAPEUTIC APPROACH OF INFLAMMATORY BOWEL DISEASES?

(2019) Sandra Maria Barbalho et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Polyphenols in the treatment of autoimmune diseases

(2019) Haroon Khan et al.   AUTOIMMUNITY REVIEWS

Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice

(2019) Rishipal R. Bansode et al.   FOOD CHEMISTRY

Grape Seed Polyphenols Ameliorated Dextran Sulfate Sodium-Induced Colitis via Suppression of Inflammation and Apoptosis

(2019) Yunxia Wang et al.   PHARMACOLOGY

Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity

(2019) Yu Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pathophysiological mechanisms of autoimmunity

(2018) Muriel Sudres et al.   Annals of the New York Academy of Sciences

Immunomodulation by food: impact on gut immunity and immune cell function

(2018) Satoshi Hachimura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study

(2018) Hani M. Khojah et al.   CLINICAL RHEUMATOLOGY

Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

(2018) Abishek B. Santhakumar et al.   FOOD AND CHEMICAL TOXICOLOGY

Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation

(2018) Lin Du et al.   Journal of Functional Foods

Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

(2018) Nicholas J Thomas et al.   Lancet Diabetes & Endocrinology

Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches

(2018) Sajid Ur Rahman et al.   INFLAMMOPHARMACOLOGY

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells

(2017) Hye-Ryung Park et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polyphenol Interactions Mitigate the Immunogenicity and Allergenicity of Gliadins

(2017) Maxime Pérot et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?

(2017) Elham Abdollahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Multifunctions of dietary polyphenols in the regulation of intestinal inflammation

(2017) Makoto Shimizu   JOURNAL OF FOOD AND DRUG ANALYSIS

Resveratrol and inflammatory bowel disease: the evidence so far

(2017) Sandra Nunes et al.   NUTRITION RESEARCH REVIEWS

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti-Inflammatory M2 State

(2017) Laura Dugo et al.   Oxidative Medicine and Cellular Longevity

Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor

(2017) Danielle K. Stamer et al.   Journal of Functional Foods

Merlot grape pomace hydroalcoholic extract improves the oxidative and inflammatory states of rats with adjuvant-induced arthritis

(2017) Geferson A. Gonçalves et al.   Journal of Functional Foods

Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes

(2017) Ivana Stojanović et al.   Journal of Functional Foods

Redox signaling in rheumatoid arthritis and the preventive role of polyphenols

(2016) Somaiya Mateen et al.   CLINICA CHIMICA ACTA

Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways

(2016) Hongqian Chu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activities

(2016) Yoon Hee Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial

(2016) Fatemeh Javadi et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection

(2016) Lana Gorenec et al.   MICROBIAL PATHOGENESIS

Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study

(2016) Heba R. Ghaiad et al.   MOLECULAR NEUROBIOLOGY

Nutraceutical therapies for atherosclerosis

(2016) Joe W. E. Moss et al.   Nature Reviews Cardiology

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis

(2016) Somaiya Mateen et al.   PLoS One

Inflammatory Bowel Disease: Pathogenesis, Causative Factors, Issues, Drug Treatment Strategies, and Delivery Approaches

(2015) Deependra Singh et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

(2015) Dipak P. Ramji et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial

(2015) Mehrzad Mehrbani et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dietary polyphenols regulate endothelial function and prevent cardiovascular disease

(2015) Kazuo Yamagata et al.   NUTRITION

Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review)

(2015) FERAH ARMUTCU et al.   Experimental and Therapeutic Medicine

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

(2014) Subash C. Gupta et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

(2014) Mengjun Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of epicatechin as one of the key bioactive constituents of polyphenol-enriched extracts that demonstrate an anti-allergic effect in a murine model of food allergy

(2014) Anurag Singh et al.   BRITISH JOURNAL OF NUTRITION

Regulation of Dendritic Cell Function by Dietary Polyphenols

(2014) Manuela del Cornò et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model

(2014) Chao-Lin Kuo et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds

(2014) Takahiro Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

(2014) María Ángeles Rosillo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females

(2014) Lisa S. McAnulty et al.   NUTRITION RESEARCH

Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice

(2013) Chia-Chi Wang et al.   BMC Complementary and Alternative Medicine

Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus

(2013) Jing-Yu Hu et al.   CYTOKINE

Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction

(2013) Min Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Grape seed proanthocyanidin extract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance

(2013) Sheikh Fayaz Ahmad et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes

(2013) Burkhard Kloesch et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The role of pattern recognition receptors in intestinal inflammation

(2013) M Fukata et al.   Mucosal Immunology

Anti-Inflammatory Effect of Procyanidins from Wild Grape (Vitis amurensis) Seeds in LPS-Induced RAW 264.7 Cells

(2013) Min-Ji Bak et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products

(2013) Brigitta Buttari et al.   Oxidative Medicine and Cellular Longevity

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

(2012) Lee Hooper et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Caffeic Acid Phenethyl Ester Suppresses the Production of Pro-inflammatory Cytokines in Hypertrophic Adipocytes through Lipopolysaccharide-Stimulated Macrophages

(2012) Sachiko Juman et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial

(2012) Gemma Chiva-Blanch et al.   CLINICAL NUTRITION

Dietary Flavonoid Naringenin Induces Regulatory T Cells via an Aryl Hydrocarbon Receptor Mediated Pathway

(2012) Hsi-Kai Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Resveratrol Modulates Interleukin-1β-induced Phosphatidylinositol 3-Kinase and Nuclear Factor κB Signaling Pathways in Human Tenocytes

(2012) Franziska Busch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4+ T cells into specific lineage effector cells

(2012) Junpeng Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

(2012) Mar Abril-Gil et al.   PHARMACOLOGICAL RESEARCH

Beneficial effects of polyphenols on cardiovascular disease

(2012) Mar Quiñones et al.   PHARMACOLOGICAL RESEARCH

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function

(2011) Gao Xuzhu et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running

(2011) Lisa S. McAnulty et al.   Applied Physiology Nutrition and Metabolism

Butein from Rhus verniciflua Protects Pancreatic β Cells against Cytokine-Induced Toxicity Mediated by Inhibition of Nitric Oxide Formation

(2011) Gil-Saeng Jeong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dietary polyphenols in the prevention and treatment of allergic diseases

(2011) A. Singh et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The molecular basis of nutritional intervention in multiple sclerosis: A narrative review

(2011) P. Riccio   COMPLEMENTARY THERAPIES IN MEDICINE

Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation

(2011) Vladimir A. Kostyuk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of regulatory T cells by green tea polyphenol EGCG

(2011) Carmen P. Wong et al.   IMMUNOLOGY LETTERS

Green tea EGCG, T cells, and T cell-mediated autoimmune diseases

(2011) Dayong Wu et al.   MOLECULAR ASPECTS OF MEDICINE

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy

(2011) James E. McLaren et al.   PROGRESS IN LIPID RESEARCH

Habitual intake of flavonoid subclasses and incident hypertension in adults

(2010) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ellagic acid and polyphenolics present in walnut kernels inhibit in vitro human peripheral blood mononuclear cell proliferation and alter cytokine production

(2010) Koren C. Anderson et al.   Annals of the New York Academy of Sciences

Polyphenol-enriched apple extract attenuates food allergy in mice

(2010) A. W. Zuercher et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Epidemiology of Atopic Dermatitis and Atopic March in Children

(2010) Jonathan M. Spergel   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis

(2010) Mi-Kyung Park et al.   IMMUNOLOGY LETTERS

Catechin inhibits adhesion and migration of peripheral blood B cells by blocking CD11b

(2010) Kazushige Kawai et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Suppression of type-I allergic responses by oral administration of grape marc fermented withLactobacillus plantarum

(2010) Takanari Tominaga et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Impact of Dietary Polyphenols on Carbohydrate Metabolism

(2010) Kati Hanhineva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media

(2010) A Overman et al.   INTERNATIONAL JOURNAL OF OBESITY

Fisetin Inhibits Lipopolysaccharide-Induced Macrophage Activation and Dendritic Cell Maturation

(2010) Sheng-Hung Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Content of Insoluble Bound Phenolics in Millets and Their Contribution to Antioxidant Capacity

(2010) Anoma Chandrasekara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

(2010) R.-Y. Huang et al.   JOURNAL OF IMMUNOLOGY

PROTECTION AGAINST ULTRAVIOLET-B RADIATION-INDUCED LOCAL and SYSTEMIC SUPPRESSION OF CONTACT HYPERSENSITIVITY and EDEMA RESPONSES IN C3H/HeN MICE BY GREEN TEA POLYPHENOLS

(2010) Santosh K. Katiyar et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells

(2010) Chiaki Iwamura et al.   ALLERGOLOGY INTERNATIONAL

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Dimeric procyanidins are inhibitors of NF-κB–DNA binding

(2009) Gerardo G. Mackenzie et al.   BIOCHEMICAL PHARMACOLOGY

Orchestration of the immune response by dendritic cells

(2009) Matthew R. Buckwalter et al.   CURRENT BIOLOGY

Reducing the allergenic capacity of peanut extracts and liquid peanut butter by phenolic compounds

(2009) Si-Yin Chung et al.   FOOD CHEMISTRY

Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation

(2009) Urban Švajger et al.   IMMUNOLOGY

Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma

(2009) Meeyoung Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development and function of TH17 cells in health and disease

(2009) Jennifer Louten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prevalence of Asthma Symptoms and Atopic Disorders in Preschool Children and the Trend over a Decade

(2009) Andrew Tai et al.   JOURNAL OF ASTHMA

Potential health benefits of avenanthramides of oats

(2009) Mohsen Meydani   NUTRITION REVIEWS

Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts

(2008) Kaliyamurthi Venkatachalam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

(−)‐Epigallocatechin‐3‐gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice

(2008) Akio Morinobu et al.   ARTHRITIS AND RHEUMATISM

The flavonoid luteolin inhibits niacin-induced flush

(2008) D Papaliodis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Feeding Our Immune System: Impact on Metabolism

(2008) Isabelle Wolowczuk et al.   Clinical & Developmental Immunology

Quercetin regulates Th1/Th2 balance in a murine model of asthma

(2008) Hee-ju Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The potential influence of fruit polyphenols on colonic microflora and human gut health

(2008) Shanthi G. Parkar et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients

(2008) Zohara Sternberg et al.   JOURNAL OF NEUROIMMUNOLOGY

A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest

(2008) Norberta W. Schoene et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inhibition of Nod2 Signaling and Target Gene Expression by Curcumin

(2008) S. Huang et al.   MOLECULAR PHARMACOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Phenolics from walnut (Juglans regia L.) kernels: Antioxidant activity and interactions with proteins

(2007) Diana O. Labuckas et al.   FOOD CHEMISTRY

Avenanthramides, polyphenols from oats, inhibit IL-1β-induced NF-κB activation in endothelial cells

(2007) Weimin Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin gallate affects human dendritic cell differentiation and maturation

(2007) Satomi Yoneyama et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY