Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response

(2020) Sarah L. Cook et al.   TRENDS IN IMMUNOLOGY

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits

(2020) Jinyong Choi et al.   NATURE IMMUNOLOGY

Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection

(2020) Dominik Alterauge et al.   Cell Reports

TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function

(2020) Fengyin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6

(2019) Annette Lahmann et al.   JOURNAL OF IMMUNOLOGY

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

(2019) Joris van der Veeken et al.   IMMUNITY

Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses

(2019) Mélanie Durand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4+ T Cell Memory

(2019) Jianlin Geng et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection

(2019) Peng Shao et al.   JOURNAL OF IMMUNOLOGY

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

(2019) Melanie S. Vacchio et al.   IMMUNITY

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

(2019) Ludovica Bruno et al.   NATURE IMMUNOLOGY

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells

(2019) Amber Papillion et al.   Science Immunology

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

(2019) Wei Xu et al.   IMMUNITY

Immunization: vital progress, unfinished agenda

(2019) Peter Piot et al.   NATURE

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

(2019) Lei Wang et al.   Cell Reports

MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

(2019) Cheng-Jang Wu et al.   Science Advances

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis -Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation

(2018) Dapeng Wang et al.   IMMUNITY

Targeted in situ genome-wide profiling with high efficiency for low cell numbers

(2018) Peter J Skene et al.   Nature Protocols

Simplified ChIP-exo assays

(2018) Matthew J. Rossi et al.   Nature Communications

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus

(2018) Chan Johng Kim et al.   IMMUNITY

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

(2018) Fengyin Li et al.   Nature Communications

The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate

(2017) Veena Krishnamoorthy et al.   IMMUNITY

Generation of T follicular helper cells in vitro : requirement for B-cell receptor cross-linking and cognate B- and T-cell interaction

(2017) Anne Kolenbrander et al.   IMMUNOLOGY

STAT4 and T-bet control follicular helper T cell development in viral infections

(2017) Jason S. Weinstein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+Th Cells

(2017) Kaitlin A. Read et al.   JOURNAL OF IMMUNOLOGY

Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4

(2017) Bi Shi et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

(2017) Fabienne Andris et al.   Frontiers in Immunology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6

(2016) Dennis Stauss et al.   EMBO JOURNAL

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

(2016) Jianhua Li et al.   NATURE

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Activin A programs the differentiation of human TFH cells

(2016) Michela Locci et al.   NATURE IMMUNOLOGY

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation

(2016) Laura A Shaw et al.   NATURE IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

CXCL13 is a plasma biomarker of germinal center activity

(2016) Colin Havenar-Daughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-7 signalling represses Bcl-6 and the TFH gene program

(2016) Paul W. McDonald et al.   Nature Communications

Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation

(2016) Xindong Liu et al.   Cell Reports

The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation

(2015) June-Yong Lee et al.   IMMUNITY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

(2015) Erica L. Stone et al.   IMMUNITY

Early Growth Response Genes 2 and 3 Regulate the Expression ofBcl6and Differentiation of T Follicular Helper Cells

(2015) Ane Ogbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

(2015) Jan P. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus–Infected Rhesus Macaques May Contribute to Accumulation of TFHin Chronic Infection

(2015) Ankita Chowdhury et al.   JOURNAL OF IMMUNOLOGY

The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection

(2015) Lifan Xu et al.   NATURE IMMUNOLOGY

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

(2015) Youn Soo Choi et al.   NATURE IMMUNOLOGY

Batf is important for IL-4 expression in T follicular helper cells

(2015) Anupama Sahoo et al.   Nature Communications

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

(2015) Tuoqi Wu et al.   Cell Reports

Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes

(2014) J. S. Weinstein et al.   BLOOD

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection

(2014) Peiyuan Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program

(2014) S. Nakayamada et al.   JOURNAL OF IMMUNOLOGY

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

(2014) Haikun Wang et al.   NATURE IMMUNOLOGY

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells

(2014) Nengming Xiao et al.   NATURE IMMUNOLOGY

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

(2014) S. Keck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Helper T-cell identity and evolution of differential transcriptomes and epigenomes

(2013) Golnaz Vahedi et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: STAT1 Is Required for IL-6-Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation

(2013) Y. S. Choi et al.   JOURNAL OF IMMUNOLOGY

Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory

(2013) Y. S. Choi et al.   JOURNAL OF IMMUNOLOGY

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

(2013) Rahul Roychoudhuri et al.   NATURE

MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation

(2013) Seung Goo Kang et al.   NATURE IMMUNOLOGY

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms

(2013) Chuanxin Huang et al.   NATURE IMMUNOLOGY

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

(2013) S.-i. Tsukumo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Follicular Helper Cell Dynamics in Germinal Centers

(2013) Z. Shulman et al.   SCIENCE

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(2013) Katerina Hatzi et al.   Cell Reports

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function

(2012) Roza I. Nurieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

BATF–JUN is critical for IRF4-mediated transcription in T cells

(2012) Peng Li et al.   NATURE

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

(2012) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Selective effects of NF-κB1 deficiency in CD4+ T cells on Th2 and TFh induction by alum-precipitated protein vaccines

(2011) Karine Serre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

(2011) Kristina T. Lu et al.   IMMUNITY

Cutting Edge: Distinct Waves of BCL6 Expression during T Follicular Helper Cell Development

(2011) D. Baumjohann et al.   JOURNAL OF IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells

(2011) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

(2010) Shane Crotty et al.   NATURE IMMUNOLOGY

KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine Receptors

(2009) Michael A. Weinreich et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

(2009) Yukiko Hiramatsu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

CtBP Is an Essential Corepressor for BCL6 Autoregulation

(2008) L. M. Mendez et al.   MOLECULAR AND CELLULAR BIOLOGY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

Worming out the biology of Runx

(2007) Rachael Nimmo et al.   DEVELOPMENTAL BIOLOGY