Article
Biology
Mary F. Fontana, Erica Ollmann Saphire, Marion Pepper
Summary: Naturally acquired immunity to malaria develops over time and repeated exposures. This study investigates whether Plasmodium parasites suppress the ability of dendritic cells (DCs) to activate T cell responses. The results show that DCs remain competent in activating T cells during Plasmodium infection, but T cell polarization and humoral responses are severely disrupted. This study provides insights into the development of adaptive responses in hosts with malaria.
Article
Engineering, Biomedical
Mai N. Vu, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Robyn Esterbauer, Thomas P. Davis, Nghia P. Truong, Adam K. Wheatley, Stephen J. Kent
Summary: This study presents a facile method to produce lipid nanoparticle subunit vaccines that exhibit high immunogenicity and provide protection against influenza virus. The vaccines showed increased serum antibody titers and superior protection against highly pathogenic viruses, along with enhanced B cell and follicular helper T cell responses. This work facilitates the rational design and rapid production of next generation nanoparticle subunit vaccines.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Immunology
Lin Dong, Yejin Cao, Hui Yang, Yueru Hou, Ying He, Yufei Wang, Qiuli Yang, Yujing Bi, Guangwei Liu
Summary: This study reveals the critical role of MST1 in T-FH cell differentiation, germinal center formation, and antibody production. MST1 deficiency enhances T-FH cell differentiation and germinal center reaction. The mTOR and HIF1α signaling pathways play a role in this process, while upregulated Foxo3 expression is essential for MST1 deficiency-directed T-FH cell differentiation.
Article
Biology
Danika L. Hill, Carly E. Whyte, Silvia Innocentin, Jia Le Lee, James Dooley, Jiong Wang, Eddie A. James, James C. Lee, William W. Kwok, Martin S. Zand, Adrian Liston, Edward J. Carr, Michelle A. Linterman
Summary: Research has shown that the formation of circulating T follicular helper cells is associated with high-titre antibody responses following influenza vaccination, but this differentiation is impaired in older people. Strategies to temporarily suppress inflammation at vaccination may enhance antibody generation in older individuals.
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Yisi Lu, Roy Jiang, Alec W. Freyn, Jiawei Wang, Shirin Strohmeier, Katlyn Lederer, Michela Locci, Hongyu Zhao, Davide Angeletti, Kevin C. O'Connor, Steven H. Kleinstein, Raffael Nachbagauer, Joe Craft
Summary: The study revealed that Tfr cells promote antigen-specific B cell responses upon influenza virus infection, essential for the development of long-term humoral memory. Their role in the generation of virus-specific, long-lived plasma cells and appropriate regulation of the BCR repertoire was also highlighted.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Chun-Shu Wong, Clarisa M. Buckner, Silvia Lucena Lage, Luxin Pei, Felipe L. Assis, Eric W. Dahlstrom, Sarah L. Anzick, Kimmo Virtaneva, Adam Rupert, Jeremy L. Davis, Ting Zhou, Elizabeth Laidlaw, Maura Manion, Frances Galindo, Megan Anderson, Catherine A. Seamon, Michael C. Sneller, Andrea Lisco, Claire Deleage, Stefania Pittaluga, Susan Moir, Irini Sereti
Summary: Low nadir CD4 T-cell counts in HIV+ patients are associated with high morbidity and mortality, and lasting immune dysfunction. In severely lymphopenic HIV+ patients, early events of immune recovery have not been fully characterized. Post-ART, there were signs of immune reconstitution with an increase in LN germinal center cells, although limited in functionality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julia Zeitraeg, Frank Dahlstroem, Yinshui Chang, Dominik Alterauge, Daniel Richter, Julia Niemietz, Dirk Baumjohann
Summary: The expression of constitutive T cell-intrinsic miRNAs is crucial for the differentiation and maintenance of Tfh cells, as well as for the GC B cell responses. Deficiency of miRNAs in CD4(+) T cells not only impairs the GC B cell responses, but also affects antigen-specific CD4(+) T cell subsets, Th1 cells, Treg cells, and Tfr cells. Overall, miRNAs play a significant role in regulating Tfh cells and T cell-B cell interactions.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anai del Rocio Campos-Contreras, Adriana Gonzalez-Gallardo, Mauricio Diaz-Munoz, Francisco G. Vazquez-Cuevas
Summary: The purinergic system plays a crucial role in the tumor microenvironment, regulating tumor cell interactions and migration. This study investigated the role of the adenosine A2B receptor (A2BR) in ovarian cancer cells and found that high A2BR expression is associated with a better prognosis. In vitro experiments showed that A2BR activation reduces cell migration and actin stress fiber expression, while A2BR knockdown increases cell migration and actin stress fiber expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Colleen L. Mayberry, Natalie A. Logan, John J. Wilson, Chih-Hao Chang
Summary: Tfh cells play a critical role in adaptive immune response by providing support to B cells. Recent studies have shown that the differentiation and activation of Tfh cells may be linked with cellular metabolic state, which is important for understanding their role in disease and functional immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Parviz Azimnasab-Sorkhabi, Maryam Soltani-Asl, Tulio Teruo Yoshinaga, Cristina de Oliveira Massoco, Jose Roberto Kfoury Junior
Summary: Cancer is classified into metabolic and/or genetic disorders, and the tryptophan catabolism pathway plays a vital role in different cancer types. This study focused on the interaction between the CTLA-4 receptor and IDO enzyme, and found that blocking IDO reduces the efficiency of anti-CTLA-4 antibody on cancer cell migration and clonogenic abilities. Further investigation into the molecular interaction between CTLA-4 and IDO could improve the efficacy of CTLA-4 immunotherapy.
IMMUNOLOGIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Miori Tanaka, Hirofumi Inoue, Nobuyuki Takahashi, Mariko Uehara
Summary: AMP-activated protein kinase (AMPK) serves as a crucial energy sensor in cellular metabolism and plays important roles under various metabolic stresses. This study aimed to explore the mechanistic link between AMPK and osteoclast differentiation, as well as the potential role of phytochemicals in anti-resorptive effects. The results suggest that AMPK inhibits RANKL-induced osteoclast differentiation by enhancing antioxidant defense system and regulating oxidative stress. AMPK activation by dietary-derived phytochemicals may have therapeutic potential for bone diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Kalliopi Ioannidou, Daba-Rokhya Ndiaye, Alessandra Noto, Craig Fenwick, Sotirios P. Fortis, Giuseppe Pantaleo, Constantinos Petrovas, Laurence de Leval
Summary: This study utilized a quantitative multiplexed immunofluorescence approach to comprehensively characterize Tfh cells in human tonsils and lymph nodes. Different subsets of Tfh cells were identified at tissue level based on differential expression of surface receptors and nuclear factors. Moreover, significant differences in Tfh cell profile signatures between health and disease were revealed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seung-Heon Baek, Yeun-Kyu Jang
Summary: AMBRA1 negatively regulates ALDH1B1 through noncanonical ubiquitination, mediated by cooperation with E3 ligases like TRAF6. It controls the K27- and K33-linked ubiquitination of ALDH1B1, impacting its expression and self-association ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nitin Khandelwal, Sheridan Cavalier, Volodymyr Rybalchenko, Ashwinikumar Kulkarni, Ashley G. Anderson, Genevieve Konopka, Jay R. Gibson
Summary: Heterozygous loss-of-function mutations in the transcription factor FOXP1 are strongly associated with autism and lead to increased intrinsic excitability in D2 SPNs. This hyperexcitability is mainly due to down-regulation of potassium currents, specifically K-IR and K-Leak. These findings suggest potential therapeutic strategies for autism forms associated with transcription factor dysfunction.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Hairong Wei, Jianlin Geng, Bi Shi, Zhenghui Liu, Yin-Hu Wang, Anna C. Stevens, Stephanie L. Sprout, Min Yao, Haikun Wang, Hui Hu
JOURNAL OF IMMUNOLOGY
(2016)
Article
Cell Biology
Liang Li, Shu-Han Yang, Yuan Yao, Yu-Qing Xie, Yan-Qing Yang, Yin-Hu Wang, Xue-Ying Yin, Hong-Di Ma, M. Eric Gershwin, Zhe-Xiong Lian
CELL DEATH & DISEASE
(2016)
Article
Immunology
Zhi-Bin Zhao, Fang-Ting Lu, Hong-Di Ma, Yin-Hu Wang, Wei Yang, Jie Long, Qi Miao, Weici Zhang, Zhigang Tian, William M. Ridgway, Jie Cao, M. Eric Gershwin, Zhe-Xiong Lian
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Jianlin Geng, Hairong Wei, Bi Shi, Yin-Hu Wang, Braxton D. Greer, Melanie Pittman, Emily Smith, Paul G. Thomas, Olaf Kutsch, Hui Hu
JOURNAL OF IMMUNOLOGY
(2019)
Article
Cell Biology
Yin-Hu Wang, Anthony Y. Tao, Stefan Feske
Article
Immunology
Axel R. Concepcion, Larry E. Wagner, Jingjie Zhu, Anthony Y. Tao, Jun Yang, Alireza Khodadadi-Jamayran, Yin-Hu Wang, Menghan Liu, Rebecca E. Rose, Drew R. Jones, William A. Coetzee, David Yule, Stefan Feske
Summary: LRRC8C is a critical component of VRAC in T cells, mediating the transport of 2'3' cGAMP and activating the STING-p53 signaling pathway. Its deletion enhances T cell function and increases T cell-dependent immune responses.
Article
Medicine, Research & Experimental
Marilena Letizia, Yin-Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Joern Felix Ziegler, Chotima Boettcher, Stephan Schlickeiser, Camila Fernandez, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Desiree Kunkel, Murali Prakriya, Ashley D. Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger
Summary: Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. This study found that store-operated Ca2+ entry (SOCE) regulates the function of immune cells in the lamina propria of IBD patients. Inhibiting SOCE reduced the production of proinflammatory cytokines, suggesting that targeting SOCE may be a potential treatment for IBD.
EMBO MOLECULAR MEDICINE
(2022)
Article
Physiology
Liwei Wang, Lucile Noyer, Yin-Hu Wang, Anthony Y. Tao, Wenyi Li, Jingjie Zhu, Pedro Saavedra, Syed T. Hoda, Jun Yang, Stefan Feske
Summary: Despite its expression in immune cells, ORAI3 appears to be dispensable or redundant for physiological and pathological immune responses mediated by these cells.
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yin -Hu Wang, Lucile Noyer, Sascha Kahlfuss, Dimitrius Raphael, Anthony Y. Tao, Ulrike Kaufmann, Jingjie Zhu, Marisa Mitchell-Flack, Ikjot Sidhu, Fang Zhou, Martin Vaeth, Paul G. Thomas, Sean P. Saunders, Kenneth Stauderman, Maria A. Curotto de Lafaille, Stefan Feske
Summary: The study reveals that SOCE through CRAC channels plays a crucial role in regulating T cell function, particularly in TH2 cells, by controlling the expression of transcription factors and cytokines. Inhibition of SOCE shows potential as a treatment for allergic airway disease.
Article
Biology
Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin-Hu Wang, Kristen N. Bricker, Anthony Y. Tao, Ping Xin, Vonn Walter, Martin T. Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S. M. Rahman, Mohamed Trebak
Summary: This study reveals that Orai3 and Orai1 mediate native CRAC channels in B cells during activation, and the combined loss of both isoforms impairs various functions in B cells, including SOCE, proliferation, survival, NFAT activation, mitochondrial respiration, glycolysis, and metabolic reprogramming. However, the deletion of Orai1 and Orai3 does not affect humoral immunity to influenza A virus infection in mice, suggesting the presence of other co-stimulatory signals that compensate for the requirement of BCR-mediated CRAC channel function in B cells. These findings provide important insights into the physiological roles of Orai1 and Orai3 proteins in SOCE and effector functions of B lymphocytes.
Review
Physiology
Yin-Hu Wang, Anthony Y. Tao, Martin Vaeth, Stefan Feske
CURRENT OPINION IN PHYSIOLOGY
(2020)