Potential immuno-nanomedicine strategies to fight COVID-19 like pulmonary infections

Targeting Danger Associated Molecular Pattern (DAMP) with CD24Fc to Reduce Acute Gvhd: Study Design on a Randomized Double Blind Placebo Controlled Phase III Clinical Trial (CATHY Study)

(2020) Pan Zheng et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV

(2020) Jared S. Morse et al.   CHEMBIOCHEM

Recent discovery and development of inhibitors targeting coronaviruses

(2020) Thanigaimalai Pillaiyar et al.   DRUG DISCOVERY TODAY

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV

(2020) Ping-Ing Lee et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Diversity at the border

(2020) Rachel L. Zemans et al.   NATURE IMMUNOLOGY

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

(2020) Víctor Casanova et al.   Frontiers in Immunology

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

(2020) Florina-Daniela Cojocaru et al.   Pharmaceutics

The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines

(2020) Weilong Shang et al.   npj Vaccines

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Déjà vu: Stimulating open drug discovery for SARS-CoV-2

(2020) Sean Ekins et al.   DRUG DISCOVERY TODAY

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

(2020) Jacques Fantini et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Association of inflammatory markers with the severity of COVID-19: a meta-analysis

(2020) Furong Zeng et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autopsy in suspected COVID-19 cases

(2020) Brian Hanley et al.   JOURNAL OF CLINICAL PATHOLOGY

Lopinavir/ritonavir did not shorten the duration of SARS CoV-2 shedding in patients with mild pneumonia in Taiwan

(2020) Chien-Yu Cheng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Resistance of children to Covid-19. How?

(2020) Alain Fischer   Mucosal Immunology

Application of nanomaterials in treatment, anti-infection and detection of coronaviruses

(2020) Ghazal Nikaeen et al.   Nanomedicine

The race for coronavirus vaccines: a graphical guide

(2020) Ewen Callaway   NATURE

Convalescent serum lines up as first-choice treatment for coronavirus

(2020) Cormac Sheridan   NATURE BIOTECHNOLOGY

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

COVID-19: faecal–oral transmission?

(2020) Jordan Hindson   Nature Reviews Gastroenterology & Hepatology

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the burden of SARS-CoV-2 in France

(2020) Henrik Salje et al.   SCIENCE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG) treatment: A case series

(2020) Negar Mohtadi et al.   VIROLOGY

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

(2020) Matthieu Mahévas et al.   BMJ-British Medical Journal

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

(2020) Mahmoud Nasrollahzadeh et al.   Nanomaterials

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

COVID-19 pneumonia: A review of typical CT findings and differential diagnosis

(2020) C. Hani et al.   Diagnostic and Interventional Imaging

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

(2020) Wei Cao et al.   Open Forum Infectious Diseases

Nanotechnology for COVID-19: Therapeutics and Vaccine Research

(2020) Gaurav Chauhan et al.   ACS Nano

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

(2020) Carsten Weiss et al.   ACS Nano

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies

(2020) Ivan Mercurio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Use of Baricitinib in Patients with Moderate and Severe COVID-19

(2020) Boghuma K Titanji et al.   CLINICAL INFECTIOUS DISEASES

Potential of regulatory T cell-based therapies in the management of severe COVID-19

(2020) Emmanuel Stephen-Victor et al.   EUROPEAN RESPIRATORY JOURNAL

Impact of Tocilizumab on mortality and/or invasive mechanical ventilation requirement in a cohort of 206 COVID-19 patients

(2020) Timothée Klopfenstein et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: A retrospective case-control survival analysis of 128 patients

(2020) Lorenzo M. Canziani et al.   JOURNAL OF AUTOIMMUNITY

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study

(2020) Abdo A. Elfiky   LIFE SCIENCES

Nano-safety research lessons for dealing with aerosol transmissions of COVID-19

(2020) Michael Riediker   Nanotoxicology

Why children avoid the worst coronavirus complications might lie in their arteries

(2020) David Cyranoski   NATURE

Nanotechnology-based disinfectants and sensors for SARS-CoV-2

(2020) Sepehr Talebian et al.   Nature Nanotechnology

Immune-mediated approaches against COVID-19

(2020) Helena F. Florindo et al.   Nature Nanotechnology

COVID-19 vaccine development and a potential nanomaterial path forward

(2020) Matthew D. Shin et al.   Nature Nanotechnology

Autoimmune and inflammatory diseases following COVID-19

(2020) Caroline Galeotti et al.   Nature Reviews Rheumatology

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

(2020) Raphaël Cauchois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

(2020) Jesse H. Erasmus et al.   Science Translational Medicine

Ongoing Clinical Trials for the Management of the COVID-19 Pandemic

(2020) Mark P. Lythgoe et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

COVID-19 Vaccine: A comprehensive status report

(2020) Simran Preet Kaur et al.   VIRUS RESEARCH

Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

(2020) Huibin Lv et al.   Cell Reports

Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19

(2020) Teluguakula Narasaraju et al.   Frontiers in Pharmacology

Combination of Ruxolitinib and Eculizumab for Treatment of Severe SARS-CoV-2-Related Acute Respiratory Distress Syndrome: A Controlled Study

(2020) Valentina Giudice et al.   Frontiers in Pharmacology

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

The immune system of children: the key to understanding SARS-CoV-2 susceptibility?

(2020) Rita Carsetti et al.   Lancet Child & Adolescent Health

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Evolution of the COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

(2020) Lang Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

(2020) Estefânia V. R. Campos et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanomedicine strategies to target coronavirus

(2020) Marcel Alexander Heinrich et al.   Nano Today

Exploring the role of triazole functionalized heteroatom co-doped carbon quantum dots against human coronaviruses

(2020) Piyush Garg et al.   Nano Today

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease

(2019) Matt Shirley   DRUGS

Novel Gold Nanorod-Based HR1 Peptide Inhibitor for Middle East Respiratory Syndrome Coronavirus

(2019) Xinyu Huang et al.   ACS Applied Materials & Interfaces

Baloxavir marboxil: the new influenza drug on the market

(2019) Ryan O’Hanlon et al.   Current Opinion in Virology

Development of Label-Free Colorimetric Assay for MERS-CoV Using Gold Nanoparticles

(2019) Hanbi Kim et al.   ACS Sensors

Camrelizumab: First Global Approval

(2019) Anthony Markham et al.   DRUGS

Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity

(2019) Xiaorong Liu et al.   MOLECULAR IMMUNOLOGY

Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)

(2019) Ping Liu et al.   Viruses-Basel

Glutathione-Capped Ag2S Nanoclusters Inhibit Coronavirus Proliferation through Blockage of Viral RNA Synthesis and Budding

(2018) Ting Du et al.   ACS Applied Materials & Interfaces

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

(2018) Sofia E. Magnusson et al.   IMMUNOLOGIC RESEARCH

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis

(2018) Mostafa Ebraheem Morra et al.   REVIEWS IN MEDICAL VIROLOGY

Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice

(2018) Axel T. Lehrer et al.   VACCINE

DNA Vaccines—How Far From Clinical Use?

(2018) Dominika Hobernik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates

(2018) Liana O. Medina et al.   Frontiers in Immunology

Nanoparticle Vaccines Against Infectious Diseases

(2018) Rashmirekha Pati et al.   Frontiers in Immunology

Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections

(2017) David Lembo et al.   Expert Opinion on Drug Delivery

Cytotoxicity and antiviral activity of electrochemical – synthesized silver nanoparticles against poliovirus

(2017) Tran Quang Huy et al.   JOURNAL OF VIROLOGICAL METHODS

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

(2017) Srinivasa Reddy Bonam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

(2017) Christopher M. Coleman et al.   VACCINE

Blue and cyan fluorescent carbon dots: one-pot synthesis, selective cell imaging and their antiviral activity

(2017) Huabing Liu et al.   RSC Advances

Adalimumab in the Treatment of Immune-Mediated Diseases

(2017) G. Lapadula et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Carbon dots as inhibitors of virus by activation of type I interferon response

(2016) Ting Du et al.   CARBON

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis

(2016) María Moreno-Sastre et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

CoVaccine HT™ adjuvant is superior to Freund's adjuvants in eliciting antibodies against the endogenous alarmin HMGB1

(2016) Nerissa Lakhan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Toll-like receptor 3 ligand specifically induced bronchial epithelial cell death in caspase dependent manner and functionally upregulated Fas expression

(2016) Yuta Koizumi et al.   ALLERGOLOGY INTERNATIONAL

Development of Liposomal Ciprofloxacin to Treat Lung Infections

(2016) David Cipolla et al.   Pharmaceutics

Oleic acid nanoemulsion for nasal vaccination: Impact on adjuvanticity based immune response

(2015) Vemireddy Sravanthi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

(2015) Randy Cheung et al.   Marine Drugs

Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions

(2015) Makoto Ujike et al.   Viruses-Basel

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Eric W F W Alton et al.   Lancet Respiratory Medicine

Arbidol as a broad-spectrum antiviral: An update

(2014) Julie Blaising et al.   ANTIVIRAL RESEARCH

Unknown

(2014) Patrick Crosswhite et al.   MOLECULAR MEDICINE

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Middle East Respiratory Syndrome Coronavirus Infections in Health Care Workers

(2013) Ziad A. Memish et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intervention strategies for emerging respiratory virus infections: policy and public health considerations

(2013) Jonathan S Nguyen-Van-Tam et al.   Current Opinion in Virology

Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

(2012) Kailang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Development of a nanoparticle-based influenza vaccine using the PRINT® technology

(2012) Ashley L. Galloway et al.   Nanomedicine-Nanotechnology Biology and Medicine

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques

(2011) Kwadwo A Kusi et al.   MALARIA JOURNAL

Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment

(2010) Elizabeth R. Johnson et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

CCR2-Antagonist Prophylaxis Reduces Pulmonary Immune Pathology and Markedly Improves Survival during Influenza Infection

(2010) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Bevacizumab

(2010) F. Kazazi-Hyseni et al.   ONCOLOGIST

Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

(2010) Neeraj Vij et al.   JOURNAL OF NANOBIOTECHNOLOGY

Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses

(2009) James A. Wiley et al.   PLoS One

Eleven years of Inflexal® V—a virosomal adjuvanted influenza vaccine

(2009) Christian Herzog et al.   VACCINE

Silver nanoparticles as a new generation of antimicrobials

(2008) Mahendra Rai et al.   BIOTECHNOLOGY ADVANCES

Role of the pulmonary epithelium and inflammatory signals in acute lung injury

(2008) Anne M Manicone   Expert Review of Clinical Immunology

Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies

(2008) Patrice Guillon et al.   GLYCOBIOLOGY