Potential of regulatory T cell-based therapies in the management of severe COVID-19

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19 pneumonia in a large cohort of patients treated with biological and targeted synthetic antirheumatic drugs

(2020) Edoardo Conticini et al.   ANNALS OF THE RHEUMATIC DISEASES

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

(2020) Wenjing Wang et al.   Cellular & Molecular Immunology

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

(2020) Xabier Michelena et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Ongoing Clinical Trials for the Management of the COVID-19 Pandemic

(2020) Mark P. Lythgoe et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The laboratory tests and host immunity of COVID-19 patients with different severity of illness

(2020) Feng Wang et al.   JCI Insight

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis

(2018) Kane Langdon et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis

(2015) Michael Bonelli et al.   RHEUMATOLOGY

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

(2013) Agnès Hartemann et al.   Lancet Diabetes & Endocrinology

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Role of regulatory T cells in coronavirus-induced acute encephalitis

(2009) Daniela Anghelina et al.   VIROLOGY