Immune Cell Connection by Tunneling Nanotubes: The Impact of Intercellular Cross-Talk on the Immune Response and Its Therapeutic Applications

Programming Cell–Cell Communications with Engineered Cell Origami Clusters

(2020) Zhilei Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

(2020) Ângela C. Crespo et al.   CELL

Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells

(2020) Shaarvari Bhat et al.   Scientific Reports

Tunneling Nanotubular Expressways for Ultrafast and Accurate M1 Macrophage Delivery of Anticancer Drugs to Metastatic Ovarian Carcinoma

(2019) Ling Guo et al.   ACS Nano

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

(2019) Anna Sartori-Rupp et al.   Nature Communications

Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages

(2019) Shanti Souriant et al.   Cell Reports

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

The Wnt/Ca 2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

(2019) Jessica Y Vargas et al.   EMBO JOURNAL

Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking

(2019) Spencer Goodman et al.   Scientific Reports

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

(2019) Nicole Matejka et al.   Radiation Oncology

Ligand Size and Conformation Affect the Behavior of Nanoparticles Coated with in Vitro and in Vivo Protein Corona

(2018) Huajin Zhang et al.   ACS Applied Materials & Interfaces

Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells

(2018) Jiancheng Wang et al.   Journal of Hematology & Oncology

Tunneling Nanotubes: Intimate Communication between Myeloid Cells

(2018) Maeva Dupont et al.   Frontiers in Immunology

Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine

(2018) Maria Omsland et al.   Scientific Reports

Live cell superresolution-structured illumination microscopy imaging analysis of the intercellular transport of microvesicles and costimulatory proteins via nanotubes between immune cells

(2018) Henriett Halász et al.   Methods and Applications in Fluorescence

TNT-Induced Phagocytosis: Tunneling Nanotubes Mediate the Transfer of Pro-Phagocytic Signals From Apoptotic to Viable Cells

(2017) Margarethe Bittins et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pseudorabies Virus US3-Induced Tunneling Nanotubes Contain Stabilized Microtubules, Interact with Neighboring Cells via Cadherins, and Allow Intercellular Molecular Communication

(2017) Robert J. J. Jansens et al.   JOURNAL OF VIROLOGY

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

(2017) Jinjin Lu et al.   Oncotarget

Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes

(2017) Inés Sáenz-de-Santa-María et al.   Oncotarget

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

(2017) Marie-Luce Vignais et al.   Stem Cells International

Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

(2017) Jennifer Ariazi et al.   Frontiers in Molecular Neuroscience

The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes

(2016) Anikó Osteikoetxea-Molnár et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia

(2016) Dagan Segal et al.   DEVELOPMENTAL CELL

Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model

(2016) H. P. Gaide Chevronnay et al.   ENDOCRINOLOGY

Nanomedicine engulfed by macrophages for targeted tumor therapy

(2016) Yueqing Gu et al.   International Journal of Nanomedicine

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

(2016) Michihiro Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Linked in: immunologic membrane nanotube networks

(2016) C. R. Zaccard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

The Role of Extracellular Vesicle and Tunneling Nanotube-Mediated Intercellular Cross-Talk Between Mesenchymal Stem Cells and Human Peripheral T Cells

(2016) Zsolt Matula et al.   STEM CELLS AND DEVELOPMENT

Signaling by Cellular Protrusions: Keeping the Conversation Private

(2016) Michael Buszczak et al.   TRENDS IN CELL BIOLOGY

Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)

(2016) Maria Omsland et al.   Oncotarget

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases?

(2016) Amin Rustom   Open Biology

Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection

(2016) Justin Ady et al.   Molecular Therapy-Oncolytics

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

(2016) Shunsuke Kimura et al.   Scientific Reports

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Structural and functional analysis of tunneling nanotubes (TnTs) usinggCW STED andgconfocal approaches

(2015) Magalie Bénard et al.   BIOLOGY OF THE CELL

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

(2015) R. Polak et al.   BLOOD

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Emerging physiological and pathological implications of tunneling nanotubes formation between cells

(2015) Sajjad Sisakhtnezhad et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cross-dressing: an alternative mechanism for antigen presentation

(2015) Stefania Campana et al.   IMMUNOLOGY LETTERS

Nanotubes Connect CD4+T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival

(2015) Saba Al Heialy et al.   JOURNAL OF IMMUNOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

(2015) Miles A. Miller et al.   Nature Communications

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Preliminary characterisation of nanotubes connecting T-cells and their use by HIV-1

(2014) Simon Lachambre et al.   BIOLOGY OF THE CELL

Cytonemes as specialized signaling filopodia

(2014) T. B. Kornberg et al.   DEVELOPMENT

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

CD40L Induces Functional Tunneling Nanotube Networks Exclusively in Dendritic Cells Programmed by Mediators of Type 1 Immunity

(2014) Colleen R. Zaccard et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

New and old roles of plasmodesmata in immunity and parallels to tunneling nanotubes

(2014) Jung-Youn Lee   PLANT SCIENCE

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Brief Reports: Lysosomal Cross-Correction by Hematopoietic Stem Cell-Derived Macrophages Via Tunneling Nanotubes

(2014) Swati Naphade et al.   STEM CELLS

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes

(2014) Venugopal Thayanithy et al.   Translational Research

The Micropillar Structure on Silk Fibroin Film Influence Intercellular Connection Mediated by Nanotubular Structures

(2014) Renchuan You et al.   Materials

Regulation of Immune Reactivity by Intercellular Transfer

(2014) Maxime Dhainaut et al.   Frontiers in Immunology

Myo10 is a key regulator of TNT formation in neuronal cells

(2013) K. Gousset et al.   JOURNAL OF CELL SCIENCE

Selective Induction of CTL Helper Rather Than Killer Activity by Natural Epitope Variants Promotes Dendritic Cell-Mediated HIV-1 Dissemination

(2013) R. B. Mailliard et al.   JOURNAL OF IMMUNOLOGY

B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes

(2013) Máté Maus et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

CD8 T Cell Memory Recall Is Enhanced by Novel Direct Interactions with CD4 T Cells Enabled by MHC Class II Transferred from APCs

(2013) Pablo A. Romagnoli et al.   PLoS One

H-Ras transfers from B to T cells via tunneling nanotubes

(2013) N Rainy et al.   Cell Death & Disease

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

(2013) Wei Ying et al.   Jove-Journal of Visualized Experiments

Tunneling nanotubes enable intercellular transfer of MHC class I molecules

(2012) Christian Schiller et al.   HUMAN IMMUNOLOGY

Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction

(2012) Yashar Seyed-Razavi et al.   IMMUNOLOGY AND CELL BIOLOGY

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells

(2012) Jennifer Pasquier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Multifaceted Roles of Tunneling Nanotubes in Intercellular Communication

(2012) Ludovica Marzo et al.   Frontiers in Physiology

TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration

(2011) Andrew Zukauskas et al.   ANGIOGENESIS

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers

(2011) Paul V. Beum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Temperature and cholera toxin B are factors that influence formation of membrane nanotubes in RT4 and T24 urothelial cancer cell lines

(2011) Doron Kabaso et al.   International Journal of Nanomedicine

Proper Regrafting of Ig-Like Transcript 2 after Trogocytosis Allows a Functional Cell-Cell Transfer of Sensitivity

(2011) K.-Y. HoWangYin et al.   JOURNAL OF IMMUNOLOGY

Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection

(2011) Irena Kadiu et al.   Journal of Neuroimmune Pharmacology

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

(2011) Linda M. Wakim et al.   NATURE

Intercellular Bridges in Vertebrate Gastrulation

(2011) Luca Caneparo et al.   PLoS One

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

T Cells Localize with Proliferating Smooth Muscle α-Actin+Cell Compartments in Asthma

(2010) David Ramos-Barbón et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Optimized methods for imaging membrane nanotubes between T cells and trafficking of HIV-1

(2010) Stefanie Sowinski et al.   METHODS

Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells

(2010) A. Chauveau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

(2010) N. Van Prooyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular nanotubes: insights from imaging studies and beyond

(2010) Johan Hurtig et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

(2009) Peter D Arkwright et al.   CELL RESEARCH

Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

(2009) Nickolay V. Bukoreshtliev et al.   FEBS LETTERS

Dendritic cell altered states: what role for calcium?

(2009) Russell D. Salter et al.   IMMUNOLOGICAL REVIEWS

Immunologic messenger molecules: Cytokines, interferons, and chemokines

(2009) Scott P. Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Paracrine induction of endothelium by tumor exosomes

(2009) Joshua L Hood et al.   LABORATORY INVESTIGATION

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration

(2009) Fiona J. Culley et al.   PLOS BIOLOGY

Different Types of Cell-to-Cell Connections Mediated by Nanotubular Structures

(2008) Peter Veranič et al.   BIOPHYSICAL JOURNAL

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

Intercellular transfer mediated by tunneling nanotubes

(2008) Hans-Hermann Gerdes et al.   CURRENT OPINION IN CELL BIOLOGY

The art of cellular communication: tunneling nanotubes bridge the divide

(2008) Steffen Gurke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Membrane nanotubes: dynamic long-distance connections between animal cells

(2008) Daniel M. Davis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer

(2008) B. J. C. Quah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA