Review
Plant Sciences
Yihao Li, Xin Zhang, Yi Zhang, Haiyun Ren
Summary: This review focuses on the organization and dynamics of actin filaments and microtubule network in guard cells during stomatal movement. The role of cytoskeletal-associated proteins in cytoskeletal rearrangements during stomatal movement is also discussed. The potential mechanisms of stomatal movement in relation to the cytoskeleton are explored, providing a foundation for further research in this field.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Beatrice Benoit, Christian Pous, Anita Baillet
Summary: The cytoskeleton is composed of different structures, including actin microfilaments, microtubules, intermediate filaments, and recently studied dynamic assemblies such as septins and the ESCRT complex. These filament-forming proteins control various cell functions through interactions with each other and with membranes. Recent research has focused on understanding how septins bind to membranes and influence their properties and functions, either directly or indirectly through other cytoskeleton elements.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingyi Wang, Na Lian, Yue Zhang, Yi Man, Lulu Chen, Haobo Yang, Jinxing Lin, Yanping Jing
Summary: The plant cytoskeleton undergoes rapid remodeling upon pathogen attacks to coordinate immune responses, while pathogens produce effectors to target the cytoskeleton for pathogenicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
R. A. Degiosio, P. G. Needham, O. A. Andrews, H. Tristan, M. J. Grubisha, J. L. Brodsky, C. Camacho, R. A. Sweet
Summary: MAP2 phosphorylation plays a critical role in regulating cytoskeletal functions in neurons. Recent research has shown that phosphorylation of MAP2 in the proline-rich and C-terminal domains of the protein affects cellular functions including microtubule assembly, microtubule binding, actin binding, and actin polymerization.
Article
Multidisciplinary Sciences
David Micinski, Lauri Lahti, Amr Abouelezz
Summary: This article describes a method using cultured rat hippocampal neurons and 3D-structured illumination microscopy to study the precise localization of the axon initial segment (AIS) and its various components in the membrane periodic skeleton (MPS). Super-resolution microscopy techniques are employed to resolve the structural details of the MPS.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Cell Biology
Noa Beatriz Martin-Cofreces, Jose Maria Valpuesta, Francisco Sanchez-Madrid
Summary: Lymphocytes undergo shape and organelle rearrangements during interaction with antigen-presenting cells, leading to activation and division through nuclear factors activation. Coordinated enrichment of chaperonin CCT and tubulins at the centrosome area support T cell activation and cytoskeletal dynamics. Proteasome enrichment in activated T cells' centrosome balances protein synthesis and degradation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Camille Cuveillier, Benoit Boulan, Charlotte Ravanello, Eric Denarier, Jean-Christophe Deloulme, Sylvie Gory-Faure, Christian Delphin, Christophe Bosc, Isabelle Arnal, Annie Andrieux
Summary: MAPs play crucial roles in the development and function of the central nervous system by influencing microtubules and actin cytoskeletons, participating in signaling pathways, and contributing to molecular actions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Abiola Abdulrahman Ayanlaja, Xiaoliang Hong, Bo Cheng, Han Zhou, Kouminin Kanwore, Piniel Alphayo-Kambey, Lin Zhang, Chuanxi Tang, Muinat Moronke Adeyanju, Dianshuai Gao
Summary: This article reviews the underappreciated functions of cytoskeletal-associated proteins (CAPs) in oncology, highlighting their roles in cell signaling, molecular conformation, organelle trafficking, cellular metabolism, and genomic modifications. CAPs are proposed as vulnerable targets for cancer systems and credible oncotargets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huan Yao, Xiaoyi Li, Lu Peng, Xinyue Hua, Qian Zhang, Kexuan Li, Yaling Huang, Hao Ji, Xiaobo Wu, Yihong Chen, Yi Yang, Jianmei Wang
Summary: The study reveals the specific interaction between 14-3-3 kappa and ADF4, which is involved in plant growth and response to stress. ADF4 plays a negative regulatory role in osmotic stress response, and its association with actin filaments is inhibited by binding with 14-3-3 kappa. These findings highlight the importance of the interaction between 14-3-3 kappa and ADF4 in regulating plant growth and tolerance.
Review
Cell Biology
Kruno Vukusic, Iva M. Tolic
Summary: This passage discusses the mechanisms of spindle elongation during anaphase B in mitosis, focusing on the core aspects of the process and the roles of anaphase A and B in physically separating sister chromatids.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Laining Zhang, Tetyana Smertenko, Deirdre Fahy, Nuria Koteyeva, Natalia Moroz, Anna Kucharova, Dominik Novak, Eduard Manoilov, Petro Smertenko, Charitha Galva, Jozef Samaj, Alla S. Kostyukova, John C. Sedbrook, Andrei Smertenko
Summary: The study focuses on the function of formins in cytokinesis, suggesting their roles in promoting microtubule polymerization, nucleating F-actin at the cell plate, retaining dynamin-related proteins at the cell plate, and remodeling the cell plate membrane. The use of SMIFH2 has helped reveal the impact of formins on these processes.
Article
Biology
Matthew H. Doran, William Lehman
Summary: Actin, a highly conserved protein, plays diverse roles in cellular processes by interacting with actin-binding proteins. The ATP-dependent cycle of myosin attachment and detachment drives muscle contraction and cellular transport. The variations in actin function are influenced by myosin isoforms and other actin-binding proteins.
Review
Cell Biology
Loic Dupre, Kaan Boztug, Laurene Pfajfer
Summary: The actin cytoskeleton in T lymphocytes plays a crucial role in controlling key cellular activities like antigen scanning and sensing, and polarized delivery of effector molecules via the immunological synapse. This dynamic cytoskeleton remodeling is orchestrated by a complex program of multiple signaling pathways, involving the coordinated actions of various actin regulatory proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wen Lu, Margot Lakonishok, Vladimir Gelfand
Summary: The study demonstrates that the Drosophila Shot protein controls the flow direction from nurse cells to the oocyte, and its loss changes transport direction resulting in halted oocyte growth. Shot is localized at the asymmetrical actin baskets on the ring canals, regulating microtubule polarity to facilitate transport driven by the minus-end-directed motor cytoplasmic dynein.
Article
Neurosciences
Pelin Zobaroglu Ozer, Dila Koyunoglu, Cagdas Devrim Son, Hayat Erdem-Yurter, Gamze Bora
Summary: Spinal muscular atrophy (SMA) is a rare neurodegenerative disease caused by the absence of survival motor neuron (SMN) protein. The study found that SMN deficiency leads to dysregulation of multiple microtubule-associated proteins (MAPs), which affects microtubule dynamics.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Theresa Zacheja, Agnes Toth, Gabor M. Harami, Qianlu Yang, Eike Schwindt, Mihaly Kovacs, Katrin Paeschke, Peter Burkovics
Article
Multidisciplinary Sciences
Adam Horvath, Mate Gyimesi, Boglarka H. Varkuti, Miklos Kepiro, Gabor Szegvari, Istvan Lorincz, Gyorgy Hegyi, Mihaly Kovacs, Andras Malnasi-Csizmadia
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Mate Gyimesi, Adam Horvath, Demeter Turos, Sharad Kumar Suthar, Mate Penzes, Csilla Kurdi, Louise Canon, Carlos Kikuti, Kathleen M. Ruppel, Darshan Trivedi, James A. Spudich, Istvan Lorincz, Anna A. Rauscher, Mihaly Kovacs, Endre Pal, Samuel Komoly, Anne Houdusse, Andras Malnasi-Csizmadia
Article
Multidisciplinary Sciences
Gabor M. Harami, Zoltan J. Kovacs, Rita Pancsa, Janos Palinkas, Veronika Barath, Krisztian Tarnok, Andras Malnasi-Csizmadia, Mihaly Kovacs
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Pharmacology & Pharmacy
Mate Gyimesi, Anna A. Rauscher, Sharad Kumar Suthar, Kamiran A. Hamow, Kinga Oravecz, Istvan Lorincz, Zsolt Borhegyi, Mate T. Deri, Adam F. Kiss, Katalin Monostory, Pal Tamas Szabo, Suman Nag, Ivan Tomasic, Jacob Krans, Patrick J. Tierney, Mihaly Kovacs, Laszlo Kornya, Andras Malnasi-Csizmadia
Summary: The study demonstrates the potential of small substitutions on the blebbistatin scaffold in drug development targeting myosin-2 family proteins, with implications for isoform-specific inhibition and pharmacokinetic properties. The inhibitory properties of NBleb and AmBleb on various myosin-2 isoforms highlight the importance of fine-tuning compound specificity.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zoltan Szeltner, Adam Poti, Gabor M. Harami, Mihaly Kovacs, David Szuts
Summary: This study demonstrated the applicability of an SV40 large T antigen-based replication system for studying DNA damage removal and DNA replicative bypass processes. While effective for examining NER and TLS, especially its one-polymerase branch, it is less suited for investigations of homology-related repair processes such as TSw.
Review
Biology
Janos Matko, Eszter Angela Toth
Summary: Nanotubular connections between different cell types play important roles in facilitating multiple collaborative activities. Although there is still debate on the spatial directionality of their growth and overall significance, studies have shown that nanotube signaling plays a crucial role in intercellular communication.
Article
Multidisciplinary Sciences
Gabor M. Harami, Janos Palinkas, Yeonee SeoI, Zoltan J. Kovacs, Mate Gyimesi, Hajnalka Harami-Papp, Keir C. Neuman, Mihaly Kovacs
Summary: In this study, the researchers found that human Bloom's syndrome helicase plays a role in the processing of displacement loops during DNA repair, depending on cellular regulatory mechanisms. In the presence of interaction partners Topoisomerase III alpha-RMI1-RMI2, the helicase's activity shifts towards efficient disruption of displacement loops, aiding genome stability and faithful inheritance.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Gabor M. Harami, Keir C. Neuman
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Tamas Annus, Dalma Mueller, Balint Jezso, Gyorgy Ullaga, Barnabas Nemeth, Gabor M. Harami, Laszlo Orban, Mihaly Kovacs, Mate Varga
Summary: RecQ helicases play crucial roles in maintaining genome integrity. Impaired function of RecQ helicase orthologs can cause severe disorders. We created a zebrafish disease model for Bloom syndrome and demonstrated that zebrafish blm mutants recapitulate major hallmarks of the human disease.
CELL DEATH & DISEASE
(2022)
Meeting Abstract
Biophysics
Gabor Harami, Zoltan J. Kovacs, Janos Palinkas, Rita Pancsa, Veronika Barath, Krisztian Tarnok, Hajnalka Harami-Papp, Andras Malnasi-Csizmadia, Mihaly Kovacs
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Zoltan J. Kovacs, Agnes Hubert, Veronika Barath, Lili Farkas, Yeonee Seol, Keir C. Neuman, Gabor Harami, Mihaly Kovacs
BIOPHYSICAL JOURNAL
(2020)