标题
System Xc−: a key regulatory target of ferroptosis in cancer
作者
关键词
-
出版物
INVESTIGATIONAL NEW DRUGS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-28
DOI
10.1007/s10637-021-01070-0
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells
- (2020) Tao Bai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma
- (2020) Yongfei Yang et al. Nature Communications
- xCT (SLC7A11) expression confers intrinsic resistance to physical plasma treatment in tumor cells
- (2020) Sander Bekeschus et al. Redox Biology
- Sulfasalazine may modulate the CD 44v9‐ xCT system and enhance CDDP ‐induced cytotoxic effects in metastatic bladder cancer
- (2019) Koichiro Ogihara et al. CANCER SCIENCE
- Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
- (2019) Yufei Wang et al. EMBO REPORTS
- ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
- (2019) Bo Chu et al. NATURE CELL BIOLOGY
- Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
- (2019) Michael D. Arensman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
- (2019) Boutaina Daher et al. CANCER RESEARCH
- ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
- (2019) Liyuan Wang et al. CELL DEATH AND DIFFERENTIATION
- Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor
- (2019) Haochen Yu et al. ONCOLOGY REPORTS
- Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma
- (2019) Shogo Okazaki et al. CANCER SCIENCE
- Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
- (2019) Tao Bai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer
- (2019) Chengcheng Gai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Recent Progress in Ferroptosis Inducers for Cancer Therapy
- (2019) Chen Liang et al. ADVANCED MATERIALS
- Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy
- (2019) Yuji Otsuki et al. CANCER SCIENCE
- LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells
- (2019) Wenchuan Qi et al. Scientific Reports
- Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma
- (2019) Jing Ye et al. Cancer Management and Research
- Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells
- (2019) Hai Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
- (2019) Nan Liu et al. BRITISH JOURNAL OF CANCER
- Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer
- (2019) Hai-Hong Zhou et al. Frontiers in Oncology
- Fighting breast cancer stem cells through the immune-targeting of the xCT cystine–glutamate antiporter
- (2018) Roberto Ruiu et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT
- (2018) Zongqi Wang et al. CANCER LETTERS
- CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer
- (2018) Eun Hye Kim et al. CANCER LETTERS
- High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: potential targets by sulfasalazine
- (2018) Fumitaka Wada et al. CANCER SCIENCE
- Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- (2018) Yuki Yamaguchi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
- (2018) Xiangming Ji et al. ONCOGENE
- Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells
- (2018) Chaoli Huang et al. ONCOLOGY REPORTS
- Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells
- (2018) Chloé Sauzay et al. Oncotarget
- The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
- (2018) Mami Sato et al. Scientific Reports
- The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis
- (2018) Keerthana Gnanapradeepan et al. Frontiers in Endocrinology
- Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells
- (2018) Shogo Okazaki et al. Oncotarget
- xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction
- (2018) Lara Cobler et al. Oncotarget
- CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells
- (2018) Sayo Horibe et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N -methyl-d -aspartate-sensitive glutamate receptor signaling
- (2018) Kentaro Suina et al. CANCER SCIENCE
- Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo
- (2018) Seung-Shick Shin et al. Oncogenesis
- Targeted p53 on Small-Molecules-Induced Ferroptosis in Cancers
- (2018) Weifen Zhang et al. Frontiers in Oncology
- Aspirin plus sorafenib potentiates cisplatin cytotoxicity in resistant head and neck cancer cells through xCT inhibition
- (2017) Jong-Lyel Roh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ferroptosis: bug or feature?
- (2017) Scott J. Dixon IMMUNOLOGICAL REVIEWS
- ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
- (2017) D Chen et al. ONCOGENE
- SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma
- (2017) Zhihong Ma et al. ONCOLOGY REPORTS
- SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties
- (2017) Monika D. Polewski et al. STEM CELLS AND DEVELOPMENT
- Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
- (2017) David S. Liu et al. Nature Communications
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells
- (2017) Shihui Hao et al. NEOPLASIA
- The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(--)
- (2016) K. Tsuchihashi et al. CANCER RESEARCH
- Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
- (2016) Xiaofang Sun et al. HEPATOLOGY
- Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
- (2016) Aline Houessinon et al. Molecular Cancer
- Increased Expression of System x c − in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance
- (2016) Monika D. Polewski et al. MOLECULAR CANCER RESEARCH
- Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity
- (2016) Katja Linher-Melville et al. PLoS One
- Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
- (2016) Masanori Hasegawa et al. Oncotarget
- Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
- (2016) Tina Sehm et al. Oncotarget
- Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis
- (2016) Tina Sehm et al. Oncotarget
- Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications
- (2016) Huai-Qiang Ju et al. Theranostics
- The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
- (2015) Christophe Louandre et al. CANCER LETTERS
- Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
- (2015) S. Lanzardo et al. CANCER RESEARCH
- Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
- (2015) Le Jiang et al. CELL CYCLE
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells
- (2015) Katja Linher-Melville et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion
- (2015) L Sleire et al. ONCOGENE
- SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma
- (2015) Stephanie M. Robert et al. Science Translational Medicine
- Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma
- (2015) E Singer et al. Cell Death & Disease
- Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress
- (2015) Eric Habib et al. Redox Biology
- RETRACTED ARTICLE: Suppression of the xCT–CD44v antiporter system sensitizes triple-negative breast cancer cells to doxorubicin
- (2014) Feng Wang et al. BREAST CANCER RESEARCH AND TREATMENT
- Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition
- (2014) P. Ye et al. MOLECULAR AND CELLULAR BIOLOGY
- Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration
- (2014) Ines M. L. Wolf et al. Scientific Reports
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
- (2013) M. Yoshikawa et al. CANCER RESEARCH
- Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib
- (2013) Christophe Louandre et al. INTERNATIONAL JOURNAL OF CANCER
- xCT, component of cysteine/glutamate transporter, as an independent prognostic factor in human esophageal squamous cell carcinoma
- (2013) Atsushi Shiozaki et al. JOURNAL OF GASTROENTEROLOGY
- The SLC3 and SLC7 families of amino acid transporters
- (2013) Dimitrios Fotiadis et al. MOLECULAR ASPECTS OF MEDICINE
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas
- (2012) Satoru Takeuchi et al. NEUROSURGERY
- System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
- (2011) Richard J Bridges et al. BRITISH JOURNAL OF PHARMACOLOGY
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
- (2011) Takatsugu Ishimoto et al. CANCER CELL
- The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine
- (2008) Jun Guan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway
- (2008) R-S Chen et al. ONCOGENE
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