The antiviral activities of TRIM proteins

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

(2020) Girish Patil et al.   Viruses-Basel

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

(2020) Dorota Kmiec et al.   mBio

The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation

(2020) Ting Mu et al.   Viruses-Basel

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner

(2020) Molly Ohainle et al.   PLoS Pathogens

TRIM2, a novel member of the antiviral family, limits New World arenavirus entry

(2019) Nicolas Sarute et al.   PLOS BIOLOGY

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

(2019) Hashim Ali et al.   Nature Communications

Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

(2019) Felix Preston Williams et al.   BIOLOGICAL CHEMISTRY

K63-linked Ubiquitin is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus Trim5alpha

(2019) Sabrina Imam et al.   JOURNAL OF VIROLOGY

E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages

(2019) Mingfeng Lu et al.   MOLECULAR IMMUNOLOGY

The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response

(2019) Hongyu Lin et al.   NATURE IMMUNOLOGY

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

(2019) Venuto et al.   Cells

The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function

(2019) Darong Yang et al.   PLoS Neglected Tropical Diseases

Nuclear localization signal in TRIM22 is essential for inhibition of type 2 porcine reproductive and respiratory syndrome virus replication in MARC-145 cells

(2019) Huiyuan Jing et al.   VIRUS GENES

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State

(2019) Tonya Kueck et al.   JOURNAL OF VIROLOGY

CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms

(2019) Mattia Ficarelli et al.   JOURNAL OF VIROLOGY

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection

(2018) Girish Patil et al.   JOURNAL OF VIROLOGY

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

TRIM proteins: New players in virus-induced autophagy

(2018) Konstantin M. J. Sparrer et al.   PLoS Pathogens

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection

(2018) Thamir Alandijany et al.   PLoS Pathogens

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

(2018) Kautilya Kumar Jena et al.   EMBO JOURNAL

TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

(2018) Maria Bottermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3

(2018) Kezhen Wang et al.   PLoS Pathogens

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

(2018) Jacint G. Sanchez et al.   JOURNAL OF MOLECULAR BIOLOGY

Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity

(2018) Florian Full et al.   Nature Microbiology

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells

(2017) Xiaofan Li et al.   PLoS Pathogens

TRIM5α Promotes Ubiquitination of Rta from Epstein–Barr Virus to Attenuate Lytic Progression

(2017) Hsiang-Hung Huang et al.   Frontiers in Microbiology

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis

(2016) Baoming Liu et al.   JOURNAL OF VIROLOGY

Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+T Cells

(2016) Esther Jimenez-Moyano et al.   JOURNAL OF VIROLOGY

An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

(2016) Ting Yuan et al.   Retrovirology

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

(2016) Wenchun Fan et al.   Scientific Reports

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

(2015) Filippo Turrini et al.   Retrovirology

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

(2015) Bishi Fu et al.   PLoS Pathogens

PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

(2015) Jacques Dutrieux et al.   PLoS Pathogens

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency

(2014) R. Sun et al.   JOURNAL OF VIROLOGY

Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of TRIM56 against Flaviviruses and Coronavirus

(2014) B. Liu et al.   JOURNAL OF VIROLOGY

Anti-HIV-1 activity of Trim 37

(2013) A. A. Tabah et al.   JOURNAL OF GENERAL VIROLOGY

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Entrapment of Viral Capsids in Nuclear PML Cages Is an Intrinsic Antiviral Host Defense against Varicella-Zoster Virus

(2011) Mike Reichelt et al.   PLoS Pathogens

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY