The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation

Restriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase

(2019) Lidan Hou et al.   Science Advances

Proteomics Based Identification of Autotaxin As An Anti-Hepatitis B Virus Factor and a Promoter of Hepatoma Cell Invasion and Migration

(2018) Sha She et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

(2018) Maria Isabel Giraldo et al.   VIRUS RESEARCH

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

(2018) A. M. Ortega-Prieto et al.   Nature Communications

Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores

(2018) Marica Grossegesse et al.   Scientific Reports

TRIM proteins: New players in virus-induced autophagy

(2018) Konstantin M. J. Sparrer et al.   PLoS Pathogens

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

(2018) Christopher John Schlicksup et al.   eLife

Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx

(2018) Guangyun Tan et al.   Frontiers in Immunology

Hepatitis B Virus-Encoded MicroRNA Controls Viral Replication

(2017) Xi Yang et al.   JOURNAL OF VIROLOGY

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

(2017) Thomas Tu et al.   Viruses-Basel

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

(2017) Yang Li et al.   Nature Communications

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

(2017) Benjamin J. Burwitz et al.   Nature Communications

A robust cell culture system supporting the complete life cycle of hepatitis B virus

(2017) Eleftherios Michailidis et al.   Scientific Reports

A critical role of hepatitis B virus polymerase in cirrhosis, hepatocellular carcinoma, and steatosis

(2017) Hea-Jong Chung et al.   FEBS Open Bio

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

(2016) Jie Li et al.   Cellular & Molecular Immunology

Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal

(2016) Nuruddin Unchwaniwala et al.   JOURNAL OF VIROLOGY

Mapping of Functional Subdomains in the Terminal Protein Domain of Hepatitis B Virus Polymerase

(2016) Daniel N. Clark et al.   JOURNAL OF VIROLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Treatment of Hepatitis B: A Concise Review

(2016) Ruma Rajbhandari et al.   Clinical and Translational Gastroenterology

TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein

(2016) Shanshan Wang et al.   Scientific Reports

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

(2016) Wenchun Fan et al.   Scientific Reports

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

Unveiling the roles of HBV polymerase for new antiviral strategies

(2015) Daniel N Clark et al.   Future Virology

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Molecular biology of hepatitis B virus infection

(2015) Christoph Seeger et al.   VIROLOGY

Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response

(2015) Anshuman Das et al.   VIROLOGY

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

(2015) Ruth E. Watkinson et al.   PLoS Pathogens

Recognition of the HIV Capsid by the TRIM5α Restriction Factor Is Mediated by a Subset of Pre-Existing Conformations of the TRIM5α SPRY Domain

(2014) Dmytro B. Kovalskyy et al.   BIOCHEMISTRY

Structural insights into the TRIM family of ubiquitin E3 ligases

(2014) Yang Li et al.   CELL RESEARCH

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Trim21: a novel negative regulator in DNA sensor signaling

(2013) Bo Yang et al.   Cellular & Molecular Immunology

Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles

(2013) Mei-Hsuan Lee et al.   HEPATOLOGY

Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors

(2013) M. Sjostrand et al.   JOURNAL OF IMMUNOLOGY

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

Residues Arg703, Asp777, and Arg781 of the RNase H Domain of Hepatitis B Virus Polymerase Are Critical for Viral DNA Synthesis

(2013) C. Ko et al.   JOURNAL OF VIROLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention

(2013) Scott A Jones et al.   Emerging Microbes & Infections

Protein-Primed Terminal Transferase Activity of Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation

(2011) Guanhua Qian et al.   BIOTECHNOLOGY LETTERS

A conserved arginine residue in the terminal protein domain of hepatitis B virus polymerase is critical for RNA pre-genome encapsidation

(2011) Y.-C. Shin et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of Hepatitis B Virus Replication by cIAP2 Involves Accelerating the Ubiquitin-Proteasome-Mediated Destruction of Polymerase

(2011) Z. Wang et al.   JOURNAL OF VIROLOGY

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

HBV Life Cycle: Entry and Morphogenesis

(2009) Stephanie Schädler et al.   Viruses-Basel

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology