Improving thermostability of (R)-selective amine transaminase from Aspergillus terreus by evolutionary coupling saturation mutagenesis

Creation of (R)-Amine Transaminase Activity within an α-Amino Acid Transaminase Scaffold

(2020) Moritz Voss et al.   ACS Chemical Biology

Transaminases for industrial biocatalysis: novel enzyme discovery

(2020) Stephen A. Kelly et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Construction of stabilized (R)-selective amine transaminase from Aspergillus terreus by consensus mutagenesis

(2019) Dong-Fang Xie et al.   JOURNAL OF BIOTECHNOLOGY

Conformational Dynamics‐Guided Loop Engineering of an Alcohol Dehydrogenase: Capture, Turnover and Enantioselective Transformation of Difficult‐to‐Reduce Ketones

(2019) Beibei Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Evolutionary coupling saturation mutagenesis: Coevolution‐guided identification of distant sites influencing Bacillus naganoensis pullulanase activity

(2019) Xinye Wang et al.   FEBS LETTERS

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Transaminases for chiral amine synthesis

(2018) Andrew Gomm et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Coevolution of both Thermostability and Activity of Polyphosphate Glucokinase from Thermobifida fusca YX

(2018) Wei Zhou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of a ( R )-selective amine transaminase from Fusarium oxysporum

(2017) Shuaihua Gao et al.   PROCESS BIOCHEMISTRY

Amine transaminases in chiral amines synthesis: recent advances and challenges

(2017) Erica E. Ferrandi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Defying the activity–stability trade-off in enzymes: taking advantage of entropy to enhance activity and thermostability

(2016) Khawar Sohail Siddiqui   CRITICAL REVIEWS IN BIOTECHNOLOGY

Direct coevolutionary couplings reflect biophysical residue interactions in proteins

(2016) Alice Coucke et al.   JOURNAL OF CHEMICAL PHYSICS

Correlated positions in protein evolution and engineering

(2016) Jorick Franceus et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Causes of evolutionary rate variation among protein sites

(2016) Julian Echave et al.   NATURE REVIEWS GENETICS

Stabilization of an α/β-Hydrolase by Introducing Proline Residues: Salicylic Acid Binding Protein 2 from Tobacco

(2015) Jun Huang et al.   BIOCHEMISTRY

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

(2015) David Bednar et al.   PLoS Computational Biology

Correction: Correlated Mutation Analysis on the Catalytic Domains of Serine/Threonine Protein Kinases

(2014) Feng Xu et al.   PLoS One

Crystal Structure of an (R)-Selective ω-Transaminase from Aspergillus terreus

(2014) Andrzej Łyskowski et al.   PLoS One

Engineering of Flexible Loops in Enzymes

(2014) Bettina M. Nestl et al.   ACS Catalysis

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines

(2013) Kateryna Fesko et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

MISTIC: mutual information server to infer coevolution

(2013) Franco L. Simonetti et al.   NUCLEIC ACIDS RESEARCH

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Teratogenic effects of thalidomide: molecular mechanisms

(2011) Takumi Ito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

(2011) F. Morcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

(2010) Thomas C. Nugent et al.   ADVANCED SYNTHESIS & CATALYSIS

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

(2009) Sebastian Schätzle et al.   ANALYTICAL CHEMISTRY

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

(2009) Najeeb Halabi et al.   CELL

Solvent accessible surface area approximations for rapid and accurate protein structure prediction

(2009) Elizabeth Durham et al.   JOURNAL OF MOLECULAR MODELING

Correlated mutation analyses on super-family alignments reveal functionally important residues

(2009) Remko K. P. Kuipers et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS