Teratogenic effects of thalidomide: molecular mechanisms

Shedding light on an old mystery: Thalidomide suppresses survival pathways to induce limb defects

(2011) Jürgen Knobloch et al.   CELL CYCLE

Induction of cereblon by NF-E2-related factor 2 in neuroblastoma cells exposed to hypoxia-reoxygenation

(2010) Kyung Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

(2009) Neil Vargesson   BIOESSAYS

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

(2009) Y. Xu et al.   BLOOD

Development and application of high-performance affinity beads: Toward chemical biology and drug discovery

(2009) Satoshi Sakamoto et al.   CHEMICAL RECORD

Cereblon is expressed in the retina and binds to voltage-gated chloride channels

(2009) Bettina Hohberger et al.   FEBS LETTERS

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

(2009) C. Therapontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of novel magnetic nano-carriers for high-performance affinity purification

(2008) Kosuke Nishio et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lenalidomide for the Treatment of B-Cell Malignancies

(2008) Asher A. Chanan-Khan et al.   JOURNAL OF CLINICAL ONCOLOGY

Higher Doses of Lenalidomide Are Associated With Unacceptable Toxicity Including Life-Threatening Tumor Flare in Patients With Chronic Lymphocytic Leukemia

(2008) Leslie A. Andritsos et al.   JOURNAL OF CLINICAL ONCOLOGY

Thalidomide Induces Limb Anomalies by PTEN Stabilization, Akt Suppression, and Stimulation of Caspase-Dependent Cell Death

(2008) J. Knobloch et al.   MOLECULAR AND CELLULAR BIOLOGY

Thalidomide Resistance Is Based on the Capacity of the Glutathione-Dependent Antioxidant Defense

(2008) Jürgen Knobloch et al.   MOLECULAR PHARMACEUTICS

Use of the rat postimplantation embryo culture to assess the embryotoxic potency within a chemical category and to identify toxic metabolites

(2008) G. Janer et al.   TOXICOLOGY IN VITRO