Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors
出版年份 2021 全文链接
标题
Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors
作者
关键词
genome-scale, personalized models, flux balance analysis, redox metabolism, radiation resistance, NADPH, glutathione, hydrogen peroxide, reactive oxygen species, The Cancer Genome Atlas
出版物
Cell Systems
Volume 12, Issue 1, Pages 68-81.e11
出版商
Elsevier BV
发表日期
2021-01-20
DOI
10.1016/j.cels.2020.12.001
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Dietary modifications for enhanced cancer therapy
- (2020) Naama Kanarek et al. NATURE
- Integrative Analysis of Novel Metabolic Subtypes in Pancreatic Cancer Fosters New Prognostic Biomarkers
- (2019) Laura Follia et al. Frontiers in Oncology
- Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
- (2019) Lucille Stuani et al. BMC BIOLOGY
- RadiationGeneSigDB: a database of oxic and hypoxic radiation response gene signatures and their utility in pre-clinical research
- (2019) Venkata SK Manem et al. BRITISH JOURNAL OF RADIOLOGY
- Mechanisms and Implications of Metabolic Heterogeneity in Cancer
- (2019) Jiyeon Kim et al. Cell Metabolism
- NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
- (2018) Wusheng Xiao et al. ANTIOXIDANTS & REDOX SIGNALING
- Applications of metabolomics to study cancer metabolism
- (2018) Akash K. Kaushik et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Targeting Glutamine Metabolism for Cancer Treatment
- (2018) Yeon-Kyung Choi et al. Biomolecules & Therapeutics
- Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells
- (2018) Hao Zhuang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Recon3D enables a three-dimensional view of gene variation in human metabolism
- (2018) Elizabeth Brunk et al. NATURE BIOTECHNOLOGY
- Constraint based modeling of metabolism allows finding metabolic cancer hallmarks and identifying personalized therapeutic windows
- (2018) Sergio Bordel Oncotarget
- Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data
- (2018) Vanessa E. Gray et al. Cell Systems
- DNA Damage, Repair, and Cancer Metabolism
- (2018) Marc-Olivier Turgeon et al. Frontiers in Oncology
- Histidine catabolism is a major determinant of methotrexate sensitivity
- (2018) Naama Kanarek et al. NATURE
- Computational prediction of changes in brain metabolic fluxes during Parkinson’s disease from mRNA expression
- (2018) Farahaniza Supandi et al. PLoS One
- Personalized Nutrition in Disrupting Cancer — Proceedings From the 2017 American College of Nutrition Annual Meeting
- (2018) Taylor C. Wallace et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses
- (2018) Joshua E. Lewis et al. SEMINARS IN RADIATION ONCOLOGY
- Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis
- (2018) Rui Benfeitas et al. EBioMedicine
- Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency
- (2017) Diego Avellaneda Matteo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome scale metabolic modeling of cancer
- (2017) Avlant Nilsson et al. METABOLIC ENGINEERING
- Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal
- (2017) Claus Jonathan Fritzemeier et al. PLoS Computational Biology
- Control of confounding in the analysis phase – an overview for clinicians
- (2017) Johnny Kahlert et al. Clinical Epidemiology
- Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells
- (2017) Francesco Ciccarese et al. Frontiers in Oncology
- Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma
- (2017) Joshua E. Lewis et al. ANTIOXIDANTS & REDOX SIGNALING
- Modulators of Redox Metabolism in Head and Neck Cancer
- (2017) Xiaofei Chen et al. ANTIOXIDANTS & REDOX SIGNALING
- Cancer treatment and survivorship statistics, 2016
- (2016) Kimberly D. Miller et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
- (2016) Xiumei Huang et al. CANCER CELL
- An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
- (2016) Amit D. Gujar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reconstruction of Tissue-Specific Metabolic Networks Using CORDA
- (2016) André Schultz et al. PLoS Computational Biology
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway
- (2016) Derek A. Franklin et al. Scientific Reports
- Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results
- (2015) Mumtahena Rahman et al. BIOINFORMATICS
- Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
- (2015) Lingtao Jin et al. CANCER CELL
- Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression
- (2015) Isaac S. Harris et al. CANCER CELL
- Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors
- (2015) Xiaofei Chen et al. Epigenetics
- Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines
- (2015) Mingcong Wang et al. PROTEOMICS
- Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
- (2015) Jade Mims et al. RADIATION RESEARCH
- A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence
- (2015) Ju-Yi Hsieh et al. Oncotarget
- Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation
- (2015) Yong-Min Choi et al. PLoS One
- Proteomic Identification of Putative Biomarkers of Radiotherapy Resistance: A Possible Role for the 26S Proteasome?
- (2015) Laura Smith et al. NEOPLASIA
- Broad Phenotypic Changes Associated with Gain of Radiation Resistance in Head and Neck Squamous Cell Cancer
- (2014) Nidhi Bansal et al. ANTIOXIDANTS & REDOX SIGNALING
- Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers
- (2014) Lifen Cao et al. ANTIOXIDANTS & REDOX SIGNALING
- Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection
- (2014) Julie A. Reisz et al. ANTIOXIDANTS & REDOX SIGNALING
- Comparison and analysis of objective functions in flux balance analysis
- (2014) Carlos Eduardo García Sánchez et al. BIOTECHNOLOGY PROGRESS
- Putative biomarkers and therapeutic targets associated with radiation resistance
- (2014) Sergej Skvortsov et al. Expert Review of Proteomics
- Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
- (2014) Caroline A. Lewis et al. MOLECULAR CELL
- A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration
- (2014) K. Yizhak et al. Molecular Systems Biology
- Quantitative flux analysis reveals folate-dependent NADPH production
- (2014) Jing Fan et al. NATURE
- COMPARTMENTS: unification and visualization of protein subcellular localization evidence
- (2014) J. X. Binder et al. Database-The Journal of Biological Databases and Curation
- Correction: Dynamic Analysis of Integrated Signaling, Metabolic, and Regulatory Networks
- (2014) Jong Min Lee et al. PLoS Computational Biology
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- The Cancer Genome Atlas Pan-Cancer analysis project
- (2013) John N Weinstein et al. NATURE GENETICS
- Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions
- (2013) Rossella Marullo et al. PLoS One
- DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
- (2013) J. Cadet et al. Cold Spring Harbor Perspectives in Biology
- Reduced Glutathione: A Radioprotector or a Modulator of DNA-Repair Activity?
- (2013) Anupam Chatterjee Nutrients
- Consistent Estimation of Gibbs Energy Using Component Contributions
- (2013) Elad Noor et al. PLoS Computational Biology
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
- (2013) Emilia Kansanen et al. Redox Biology
- Quantitative Assignment of Reaction Directionality in a Multicompartmental Human Metabolic Reconstruction
- (2012) H.S. Haraldsdóttir et al. BIOPHYSICAL JOURNAL
- Cellular redox potential and the biomolecular electrochemical series: A systems hypothesis
- (2012) Venkatesh Mallikarjun et al. FREE RADICAL BIOLOGY AND MEDICINE
- On the Chemical Repair of DNA Radicals by Glutathione: Hydrogen vs Electron Transfer
- (2012) Juan Raúl Alvarez-Idaboy et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Integration of expression data in genome-scale metabolic network reconstructions
- (2012) Anna S. Blazier et al. Frontiers in Physiology
- Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells
- (2011) Fei Yin et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Elimination of Thermodynamically Infeasible Loops in Steady-State Metabolic Models
- (2011) Jan Schellenberger et al. BIOPHYSICAL JOURNAL
- Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites
- (2011) M. Zhao et al. CLINICAL CANCER RESEARCH
- Predicting selective drug targets in cancer through metabolic networks
- (2011) O. Folger et al. Molecular Systems Biology
- An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies
- (2011) Peter C. Austin MULTIVARIATE BEHAVIORAL RESEARCH
- Global quantification of mammalian gene expression control
- (2011) Björn Schwanhäusser et al. NATURE
- A Model of Redox Kinetics Implicates the Thiol Proteome in Cellular Hydrogen Peroxide Responses
- (2010) Nnenna J. Adimora et al. ANTIOXIDANTS & REDOX SIGNALING
- Functional integration of a metabolic network model and expression data without arbitrary thresholding
- (2010) Paul A. Jensen et al. BIOINFORMATICS
- Differential Gene Expression Profiles of Radioresistant Non–Small-Cell Lung Cancer Cell Lines Established by Fractionated Irradiation: Tumor Protein p53-Inducible Protein 3 Confers Sensitivity to Ionizing Radiation
- (2010) Young Sook Lee et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Metabolic Network Analysis of Pseudomonas aeruginosa during Chronic Cystic Fibrosis Lung Infection
- (2010) M. A. Oberhardt et al. JOURNAL OF BACTERIOLOGY
- What is flux balance analysis?
- (2010) Jeffrey D Orth et al. NATURE BIOTECHNOLOGY
- Glucose oxidase — An overview
- (2009) Sandip B. Bankar et al. BIOTECHNOLOGY ADVANCES
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production
- (2009) Caroline Colijn et al. PLoS Computational Biology
- Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli
- (2008) Markus W. Covert et al. BIOINFORMATICS
- Network-based prediction of human tissue-specific metabolism
- (2008) Tomer Shlomi et al. NATURE BIOTECHNOLOGY
- Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells
- (2008) Ira Skvortsova et al. PROTEOMICS
- Context-Specific Metabolic Networks Are Consistent with Experiments
- (2008) Scott A. Becker et al. PLoS Computational Biology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More