The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Isolation and characterization of new human carrier peptides from two important vaccine immunogens

(2020) Paeton L. Wantuch et al.   VACCINE

Identification of antigens presented by MHC for vaccines against tuberculosis

(2020) Paulo Bettencourt et al.   npj Vaccines

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Potential Therapeutic Targets and Promising Drugs for Combating SARS‐CoV‐2

(2020) Hong Zhou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

(2020) Alba Grifoni et al.   Cell Host & Microbe

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

(2020) Birkir Reynisson et al.   NUCLEIC ACIDS RESEARCH

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HLA-DP peptide repertoire from human respiratory syncytial virus is focused on major structural proteins with the exception of the viral polymerase

(2020) Elena Lorente et al.   Journal of Proteomics

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

Proteomics analysis reveals that structural proteins of the virion core and involved in gene expression are the main source for HLA class II ligands in vaccinia virus-infected cells

(2019) Elena Lorente et al.   JOURNAL OF PROTEOME RESEARCH

Ligandomes obtained from different HLA-class II-molecules are homologous for N- and C-terminal residues outside the peptide-binding cleft

(2019) Arieke S.B. Kampstra et al.   IMMUNOGENETICS

A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients

(2019) Antonino Cassotta et al.   NATURE MEDICINE

Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T-cell epitopes

(2019) Sylvain Meunier et al.   Cellular & Molecular Immunology

MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arena

(2018) Valerie Quarmby et al.   Expert Review of Proteomics

MHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity

(2018) Nobuo Sekiguchi et al.   mAbs

The Immune Epitope Database (IEDB): 2018 update

(2018) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

(2017) Moustafa Hamze et al.   Frontiers in Immunology

Design and engineering of deimmunized biotherapeutics

(2016) Karl E Griswold et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification and Characterization of Complex Glycosylated Peptides Presented by the MHC Class II Processing Pathway in Melanoma

(2016) Stacy A. Malaker et al.   JOURNAL OF PROTEOME RESEARCH

Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes

(2015) Sinu Paul et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Drug Discovery Applications for KNIME: An Open Source Data Mining Platform

(2013) Michael P. Mazanetz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals

(2008) Junbao Yang et al.   INTERNATIONAL IMMUNOLOGY

Vaccinia Peptides Eluted from HLA-DR1 Isolated from Virus-Infected Cells Are Recognized by CD4+T Cells from a Vaccinated Donor

(2008) Iwona Strug et al.   JOURNAL OF PROTEOME RESEARCH