MHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity

Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

(2017) Moustafa Hamze et al.   Frontiers in Immunology

Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques

(2016) Jing Fang et al.   mAbs

Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity

(2016) Anette Karle et al.   mAbs

Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

(2016) Anshu Kuriakose et al.   Journal of Immunology Research

Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody

(2015) L. Xue et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A fit-for-purpose strategy for the risk-based immunogenicity testing of biotherapeutics: a European industry perspective

(2015) Cathelijne Kloks et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

(2014) Verena Rombach-Riegraf et al.   PLoS One

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

Anti-drug antibodies in psoriasis: a critical evaluation of clinical significance and impact on treatment response

(2013) Leeyen Hsu et al.   Expert Review of Clinical Immunology

Limited Promiscuity of HLA-DRB1 Presented Peptides Derived of Blood Coagulation Factor VIII

(2013) Simon D. van Haren et al.   PLoS One

Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes

(2012) Cristina Maria Costantino et al.   PLoS One

Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-Derived Peptides by HLA-DR on Human Dendritic Cells

(2012) Anette C. Karle et al.   PLoS One

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

(2012) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

(2011) Leonard Moise et al.   CLINICAL IMMUNOLOGY

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis

(2011) D. Pascual-Salcedo et al.   RHEUMATOLOGY

Naturally processed T cell–activating peptides of the major birch pollen allergen

(2010) Sonja Mutschlechner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review

(2010) Charlotte Krieckaert et al.   ARTHRITIS RESEARCH & THERAPY

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

(2009) Constanze A. Weber et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunogenicity negatively influences the outcome of adalimumab treatment in Crohn’s disease

(2008) R. L. WEST et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Development of novel magnetic nano-carriers for high-performance affinity purification

(2008) Kosuke Nishio et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

(2008) A DEGROOT et al.   CURRENT OPINION IN PHARMACOLOGY