MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arena
出版年份 2018 全文链接
标题
MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arena
作者
关键词
-
出版物
Expert Review of Proteomics
Volume -, Issue -, Pages 1-16
出版商
Informa UK Limited
发表日期
2018-09-09
DOI
10.1080/14789450.2018.1521279
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- (2018) Alejandro Balsa et al. RHEUMATOLOGY
- Deciphering the MHC-associated peptidome: a review of naturally processed ligand data
- (2017) Kerrie Vaughan et al. Expert Review of Proteomics
- Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction
- (2017) Jennifer G. Abelin et al. IMMUNITY
- Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells
- (2017) Caroline Boudousquie et al. IMMUNOLOGY
- Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics
- (2017) Christian D. Kelstrup et al. JOURNAL OF PROTEOME RESEARCH
- Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens
- (2017) Michael S. Khodadoust et al. NATURE
- Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices
- (2017) Santiswarup Singha et al. Nature Nanotechnology
- Next generation antibody drugs: pursuit of the 'high-hanging fruit'
- (2017) Paul J. Carter et al. NATURE REVIEWS DRUG DISCOVERY
- Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools
- (2017) Kasper Lamberth et al. Science Translational Medicine
- Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors
- (2017) Moustafa Hamze et al. Frontiers in Immunology
- Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation
- (2017) Marek Wieczorek et al. Frontiers in Immunology
- Pre-existing Antibody: Biotherapeutic Modality-Based Review
- (2016) Boris Gorovits et al. AAPS Journal
- Hunting down factor VIII in the immunopeptidome
- (2016) Robin B. Hartholt et al. CELLULAR IMMUNOLOGY
- Immunogenicity of therapeutic recombinant immunotoxins
- (2016) Ronit Mazor et al. IMMUNOLOGICAL REVIEWS
- Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity
- (2016) Anette Karle et al. mAbs
- Expanding antigen-specific regulatory networks to treat autoimmunity
- (2016) Xavier Clemente-Casares et al. NATURE
- Long-acting recombinant factor VIII Fc fusion protein (rFVIIIFc) for perioperative haemostatic management in severe haemophilia A
- (2016) Johnny Mahlangu et al. THROMBOSIS AND HAEMOSTASIS
- Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications
- (2016) Anshu Kuriakose et al. Journal of Immunology Research
- An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction
- (2016) Lenka Potocnakova et al. Journal of Immunology Research
- Evaluating and Reporting the Immunogenicity Impacts for Biological Products—a Clinical Pharmacology Perspective
- (2015) Yow-Ming C. Wang et al. AAPS Journal
- Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium
- (2015) B. Rup et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity
- (2015) J. N. Mahlangu et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Alternative molecular formats and therapeutic applications for bispecific antibodies
- (2015) Christoph Spiess et al. MOLECULAR IMMUNOLOGY
- The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model
- (2015) Juliana Bessa et al. PHARMACEUTICAL RESEARCH
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides—Harmonized Terminology and Tactical Recommendations
- (2014) G. Shankar et al. AAPS Journal
- A review of quantitative modeling of B cell responses to antigenic challenge
- (2014) Timothy P. Hickling et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
- (2014) Mahesh Yadav et al. NATURE
- Biopharmaceutical benchmarks 2014
- (2014) Gary Walsh NATURE BIOTECHNOLOGY
- The immune epitope database (IEDB) 3.0
- (2014) Randi Vita et al. NUCLEIC ACIDS RESEARCH
- Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro
- (2014) Verena Rombach-Riegraf et al. PLoS One
- Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout
- (2014) Peter E Lipsky et al. ARTHRITIS RESEARCH & THERAPY
- T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation
- (2013) Vibha Jawa et al. CLINICAL IMMUNOLOGY
- A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population
- (2013) Denise M. McKinney et al. IMMUNOGENETICS
- Immunogenicity of mAbs in non-human primates during nonclinical safety assessment
- (2013) Peter J.K. van Meer et al. mAbs
- Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins
- (2013) Vera Brinks et al. PHARMACEUTICAL RESEARCH
- Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity
- (2013) Zenjiro Sampei et al. PLoS One
- The Fate of Taspoglutide, a Weekly GLP-1 Receptor Agonist, Versus Twice-Daily Exenatide for Type 2 Diabetes: The T-emerge 2 trial
- (2012) J. Rosenstock et al. DIABETES CARE
- Characterization and Quantitation of Aggregates and Particles in Interferon-β Products: Potential Links Between Product Quality Attributes and Immunogenicity
- (2012) James G. Barnard et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- The impact of antibodies on clinical outcomes in diseases treated with therapeutic protein: Lessons learned from infantile Pompe disease
- (2011) Suhrad G. Banugaria et al. GENETICS IN MEDICINE
- NetMHCcons: a consensus method for the major histocompatibility complex class I predictions
- (2011) Edita Karosiene et al. IMMUNOGENETICS
- Pharmacogenetics and the immunogenicity of protein therapeutics
- (2011) Chen Yanover et al. NATURE BIOTECHNOLOGY
- The ABA-1 allergen of the nematode Ascaris suum: epitope stability, mass spectrometry, and N-terminal sequence comparison with its homologue in Toxocara canis
- (2010) J. F. CHRISTIE et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Considerations for optimization and validation of an in vitro PBMC derived T cell assay for immunogenicity prediction of biotherapeutics
- (2010) Danika Wullner et al. CLINICAL IMMUNOLOGY
- Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
- (2010) Scheherazade Sadegh-Nasseri et al. IMMUNOLOGIC RESEARCH
- Impact of Product-Related Factors on Immunogenicity of Biotherapeutics
- (2010) Satish Kumar Singh JOURNAL OF PHARMACEUTICAL SCIENCES
- Safety and immunogenicity of a new formulation of interferon β-1a (Rebif® New Formulation) in a Phase IIIb study in patients with relapsing multiple sclerosis: 96-week results
- (2009) G Giovannoni et al. Multiple Sclerosis Journal
- Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies
- (2009) Rafael Ponce et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
- (2008) A. S. De Groot et al. BLOOD
- A Fast SEQUEST Cross Correlation Algorithm
- (2008) Jimmy K. Eng et al. JOURNAL OF PROTEOME RESEARCH
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