Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

Circulating T cells to infliximab are detectable mainly in treated patients developing anti-drug antibodies and hypersensitivity reactions

(2016) A. Vultaggio et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity

(2016) Anette Karle et al.   mAbs

The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors

(2015) Claire Chevaleyre et al.   JOURNAL OF IMMUNOLOGY

Functional Analysis of the Anti-adalimumab Response Using Patient-derived Monoclonal Antibodies

(2014) Pauline A. van Schouwenburg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

(2014) Verena Rombach-Riegraf et al.   PLoS One

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

(2014) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the Immunogenicity of Protein Drugs by ApplyingIn VitroMHC Binding Data and the Immune Epitope Database and Analysis Resource

(2013) Sinu Paul et al.   Clinical & Developmental Immunology

Allergologicalin vitroandin vivoevaluation of patients with hypersensitivity reactions to infliximab

(2013) Andrea Matucci et al.   CLINICAL AND EXPERIMENTAL ALLERGY

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

Hierarchy of CD4 T Cell Epitopes of the ANRS Lipo5 Synthetic Vaccine Relies on the Frequencies of Pre-Existing Peptide-Specific T Cells in Healthy Donors

(2013) F. A. Castelli et al.   JOURNAL OF IMMUNOLOGY

Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire

(2012) W. W. Kwok et al.   JOURNAL OF IMMUNOLOGY

Quantitative analysis of the CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors

(2011) Stephanie Delluc et al.   FASEB JOURNAL

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential

(2010) S. Delluc et al.   BLOOD

Have we overestimated the benefit of human(ized) antibodies?

(2010) Daniel R. Getts et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical response, pharmacokinetics, development of human anti-chimaeric antibodies, and synovial tissue response to rituximab treatment in patients with rheumatoid arthritis

(2009) R M Thurlings et al.   ANNALS OF THE RHEUMATIC DISEASES

Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

(2008) T R D J Radstake et al.   ANNALS OF THE RHEUMATIC DISEASES

Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin

(2008) Brian G. Feagan et al.   Clinical Gastroenterology and Hepatology

Immunoprevalence of the CD4+T-cell response to HIV Tat and Vpr proteins is provided by clustered and disperse epitopes, respectively

(2008) Florence A. Castelli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology