Advances in Brain Amyloid Imaging

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease

(2020) Sanka Amadoru et al.   Alzheimers Research & Therapy

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults

(2020) Tengfei Guo et al.   NEUROLOGY

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology

(2019) Vincent Doré et al.   Alzheimers & Dementia

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

(2019) Gil D. Rabinovici et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

(2019) Clifford R. Jack et al.   JAMA Neurology

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes

(2019) Clifford R Jack et al.   BRAIN

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease

(2019) Sebastian Palmqvist et al.   EMBO Molecular Medicine

β-Amyloid PET and neuropathology in dementia with Lewy bodies

(2019) Kejal Kantarci et al.   NEUROLOGY

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

(2018) Michael Navitsky et al.   Alzheimers & Dementia

Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition

(2018) Ann D. Cohen et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort

(2018) Arno de Wilde et al.   JAMA Neurology

Estimation of amyloid distribution by [18F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition

(2018) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Implementing the centiloid transformation for 11C-PiB and β-amyloid 18F-PET tracers using CapAIBL

(2018) Pierrick Bourgeat et al.   NEUROIMAGE

Disclosure of amyloid positron emission tomography results to individuals without dementia: a systematic review

(2018) Arno de Wilde et al.   Alzheimers Research & Therapy

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

(2018) Renaud La Joie et al.   Alzheimers & Dementia

Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods

(2018) Mark R. Battle et al.   EJNMMI Research

18F-Florbetaben PET beta-amyloid binding expressed in Centiloids

(2017) Christopher C. Rowe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia

(2017) Kyoko Mashima et al.   EUROPEAN NEUROLOGY

Amyloid- and FDG-PET in sporadic Creutzfeldt-Jakob disease: Correlation with pathological prion protein in neuropathology

(2017) Jordi A. Matías-Guiu et al.   Prion

Aβ-amyloid and Tau Imaging in Dementia

(2017) Victor L. Villemagne et al.   SEMINARS IN NUCLEAR MEDICINE

Posterior Cortical Atrophy: A Rare Form of Dementia with in vivo Evidence of Amyloid-β Accumulation

(2017) Olli Tenovuo et al.   JOURNAL OF ALZHEIMERS DISEASE

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Evidence of increased brain amyloid in severe TBI survivors at 1, 12, and 24 months after injury: report of 2 cases

(2016) Joshua W. Gatson et al.   JOURNAL OF NEUROSURGERY

Standardized Expression of 18F-NAV4694 and 11C-PiB  -Amyloid PET Results with the Centiloid Scale

(2016) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

[ 18 F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β pathology

(2015) Dietmar Rudolf Thal et al.   Alzheimers & Dementia

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

(2015) Osama Sabri et al.   Alzheimers & Dementia

Measurement of Longitudinal  -Amyloid Change with 18F-Florbetapir PET and Standardized Uptake Value Ratios

(2015) S. M. Landau et al.   JOURNAL OF NUCLEAR MEDICINE

PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies

(2015) Stephen N. Gomperts et al.   Neurodegenerative Diseases

Amyloid-β11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

(2015) Enchi Liu et al.   NEUROLOGY

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

(2015) Michael Schöll et al.   Scientific Reports

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

(2015) Craig Curtis et al.   JAMA Neurology

Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study

(2014) Kevin T Ong et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Appropriate Use Criteria for Amyloid PET: A Report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association

(2013) K. A. Johnson et al.   JOURNAL OF NUCLEAR MEDICINE

Head-to-Head Comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for  -Amyloid Imaging in Aging and Dementia

(2013) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Brain  -amyloid load approaches a plateau

(2013) C. R. Jack et al.   NEUROLOGY

Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury

(2013) Young T. Hong et al.   JAMA Neurology

Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study

(2012) Milos D. Ikonomovic et al.   ACTA NEUROPATHOLOGICA

Why we need two cutoffs for amyloid imaging: Early versus Alzheimer's-like amyloid-positivity

(2012) William Klunk et al.   Alzheimers & Dementia

Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer’s disease: a voxelwise PiB–PET longitudinal study

(2012) Nicolas Villain et al.   BRAIN

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment

(2012) V. Camus et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease

(2012) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography

(2012) David A Wolk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals

(2012) Reisa A. Sperling et al.   NEUROBIOLOGY OF AGING

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

(2012) M. Scholl et al.   NEUROLOGY

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

In Vivo Fibrillar β-Amyloid Detected Using [11C]PiB Positron Emission Tomography and Neuropathologic Assessment in Older Adults

(2011) Jitka Sojkova et al.   ARCHIVES OF NEUROLOGY

Association Between In Vivo Fluorine 18–Labeled Flutemetamol Amyloid Positron Emission Tomography Imaging and In Vivo Cerebral Cortical Histopathology

(2011) David A. Wolk   ARCHIVES OF NEUROLOGY

Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults

(2011) Jitka Sojkova et al.   ARCHIVES OF NEUROLOGY

Using Positron Emission Tomography and Florbetapir F 18 to Image Cortical Amyloid in Patients With Mild Cognitive Impairment or Dementia Due to Alzheimer Disease

(2011) Adam S. Fleisher   ARCHIVES OF NEUROLOGY

Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease

(2011) Bradley T. Hyman   ARCHIVES OF NEUROLOGY

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging

(2011) Cristian E. Leyton et al.   BRAIN

In Vivo Human Amyloid Imaging

(2011) J. Sojkova et al.   Current Alzheimer Research

Cognitive Reserve in Aging

(2011) A. M. Tucker et al.   Current Alzheimer Research

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings

(2011) Maïté Formaglio et al.   JOURNAL OF NEUROLOGY

Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias

(2011) V. L. Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

(2011) Henryk Barthel et al.   LANCET NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Testing the Right Target and Right Drug at the Right Stage

(2011) R. A. Sperling et al.   Science Translational Medicine

Amyloid imaging in prodromal Alzheimer's disease

(2011) Rik Ossenkoppele et al.   Alzheimers Research & Therapy

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

(2010) Gregory A. Dierksen et al.   ANNALS OF NEUROLOGY

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

(2010) Gil D. Rabinovici et al.   BRAIN

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

(2010) Masamichi Yokokura et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18)

(2010) D. F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Amyloid imaging of Lewy body-associated disorders

(2010) Erin R. Foster et al.   MOVEMENT DISORDERS

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

(2010) Ansgar J. Furst et al.   NEUROBIOLOGY OF AGING

Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes

(2010) M.E. Kalaitzakis et al.   NEUROBIOLOGY OF DISEASE

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB

(2010) S. M. Resnick et al.   NEUROLOGY

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer’s disease

(2009) Rebecca F. Rosen et al.   ACTA NEUROPATHOLOGICA

AZD4694: Fluorinated Positron Emission Tomography (PET) radioligand for detection of β-amyloid deposits

(2009) Anna K. Sundgren-Andersson et al.   Alzheimers & Dementia

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

(2009) Victor L. Villemagne et al.   ARCHIVES OF NEUROLOGY

Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease

(2009) John C. Morris et al.   ARCHIVES OF NEUROLOGY

Absence of Pittsburgh Compound B Detection of Cerebral Amyloid β in a Patient With Clinical, Cognitive, and Cerebrospinal Fluid Markers of Alzheimer Disease

(2009) Nigel J. Cairns et al.   ARCHIVES OF NEUROLOGY

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

Detection of amyloid in Alzheimer’s disease with positron emission tomography using [11C]AZD2184

(2009) Svante Nyberg et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Posterior cortical atrophy with [11C] Pittsburgh compound B accumulation in the primary visual cortex

(2009) Taiki Kambe et al.   JOURNAL OF NEUROLOGY

11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease

(2009) V L Villemagne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Characterization of PiB Binding to White Matter in Alzheimer Disease and Other Dementias

(2009) M. T. Fodero-Tavoletti et al.   JOURNAL OF NUCLEAR MEDICINE

Phase 1 Study of the Pittsburgh Compound B Derivative 18F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease

(2009) N. Nelissen et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of 18F-FDG and PiB PET in Cognitive Impairment

(2009) V. J. Lowe et al.   JOURNAL OF NUCLEAR MEDICINE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics

(2009) Walter Maetzler et al.   NEUROBIOLOGY OF DISEASE

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia

(2009) M. A. Burack et al.   NEUROLOGY

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

(2009) Roy O Weller et al.   Alzheimers Research & Therapy

Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia

(2008) Gil D. Rabinovici et al.   ANNALS OF NEUROLOGY

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Carbon 11–Labeled Pittsburgh Compound B Positron Emission Tomographic Amyloid Imaging in Patients With APP Locus Duplication

(2008) Anne M. Remes et al.   ARCHIVES OF NEUROLOGY

Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B

(2008) Ville Leinonen   ARCHIVES OF NEUROLOGY

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Alzheimer Disease and Cognitive Reserve

(2008) Catherine M. Roe et al.   ARCHIVES OF NEUROLOGY

Synthesis of 18F-labelled 2-(4′-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB

(2008) K. Serdons et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease

(2008) J. Koivunen et al.   BRAIN

Episodic memory loss is related to hippocampal-mediated  -amyloid deposition in elderly subjects

(2008) E. C. Mormino et al.   BRAIN

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

(2008) Clifford R. Jack et al.   BRAIN

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

(2008) P Edison et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

(2008) Christopher C Rowe et al.   LANCET NEUROLOGY

The ART of Loss: Aβ Imaging in the Evaluation of Alzheimer’s Disease and other Dementias

(2008) Victor L. Villemagne et al.   MOLECULAR NEUROBIOLOGY

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Imaging amyloid deposition in Lewy body diseases

(2008) S. N. Gomperts et al.   NEUROLOGY

Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease

(2008) V.L. Villemagne et al.   NEUROPSYCHOLOGIA

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING

[11C]PIB binding in Parkinson's disease dementia

(2007) Walter Maetzler et al.   NEUROIMAGE

Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer’s disease

(2007) Alexander Drzezga et al.   NEUROIMAGE

[11C]-PIB imaging in patients with Parkinson's disease: Preliminary results

(2007) A. Johansson et al.   PARKINSONISM & RELATED DISORDERS