Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

(2019) Oliver Preische et al.   NATURE MEDICINE

Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly

(2019) Andreas Hahn et al.   CEREBRAL CORTEX

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease

(2019) Suzanne E. Schindler et al.   Alzheimers & Dementia

Alzheimer disease and aducanumab: adjusting our approach

(2019) Dennis J. Selkoe   Nature Reviews Neurology

Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures

(2019) David S. Knopman   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease

(2019) Niklas Mattsson et al.   JAMA Neurology

Subthreshold amyloid and its biological and clinical meaning

(2019) Gérard N. Bischof et al.   NEUROLOGY

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography

(2019) Niklas Mattsson et al.   JAMA Neurology

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

(2018) Oskar Hansson et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer’s disease

(2018) Hlin Kvartsberg et al.   ACTA NEUROPATHOLOGICA

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

(2018) Eric McDade et al.   NEUROLOGY

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer’s Disease Pathology Between Three Independent Assay Platforms

(2017) James D. Doecke et al.   JOURNAL OF ALZHEIMERS DISEASE

The Montreal Cognitive Assessment: Normative Data from a Large Swedish Population-Based Cohort

(2017) Emma Borland et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood-based NfL

(2017) Oskar Hansson et al.   NEUROLOGY

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

Unbiased estimates of cerebrospinal fluid β-amyloid 1–42 cutoffs in a large memory clinic population

(2017) Daniela Bertens et al.   Alzheimers Research & Therapy

Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment

(2017) Shorena Janelidze et al.   JAMA Neurology

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

(2017) Niklas Mattsson et al.   JAMA Neurology

Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease

(2017) Philip S. Insel et al.   Frontiers in Neuroscience

Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease

(2016) Andrei G. Vlassenko et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography

(2016) Sebastian Palmqvist et al.   BRAIN

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

(2016) Niklas Mattsson et al.   EMBO Molecular Medicine

Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer’s Disease

(2016) Piotr Lewczuk et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology

(2016) Philip S. Insel et al.   NEUROLOGY

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

(2015) Sylvia Villeneuve et al.   BRAIN

Measurement of Longitudinal  -Amyloid Change with 18F-Florbetapir PET and Standardized Uptake Value Ratios

(2015) S. M. Landau et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls

(2015) Hlin Kvartsberg et al.   Alzheimers Research & Therapy

mixtools: AnRPackage for Analyzing Finite Mixture Models

(2015) Tatiana Benaglia et al.   Journal of Statistical Software

Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease

(2014) Niklas Mattsson et al.   BRAIN

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42

(2014) Sebastian Palmqvist et al.   JAMA Neurology

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

(2012) Xuejing Li et al.   NEUROBIOLOGY OF DISEASE

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON