期刊
NEUROBIOLOGY OF DISEASE
卷 34, 期 1, 页码 107-112出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2008.12.008
关键词
Aged; Amyloid metabolism; Cerebrospinal fluid; Diagnostic imaging; Lewy body disease variant
资金
- University of Tuebingen [201-0-0]
- Robert Bosch Foundation [32.5.1141.0019.0]
About one fourth of Lewy body disease (LBD) patients show cortical beta-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [C-11]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [C-11]PIB-PET, and were classified as either PIB(+) or PIB(-) according to cortical PIB uptake. PIB(+) and PIB(-) patients were then compared according to demographic, clinical, biochemical and genetic parameters. None of the PDND, but four PDD and four DLB subjects were PIB(+). In PIB(+) subjects, ApoE4 prevalence was higher, CSF Abeta42 levels were lower and, among demented patients, PIB-binding was associated with a lower MMSE score. Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical beta-amyloid show characteristics usually observed in AD. (C) 2009 Elsevier Inc. All rights reserved.
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